Yuanxin Liang, MD, PhD
Assistant Professor of PathologyCards
About
Research
Publications
2026
Histomorphologic analysis and clinical correlation of atypical apocrine lesions in breast pathology
Podany P, Zhan H, Colón-Cartagena L, Ai D, Du J, Krishnamurti U, Liang Y. Histomorphologic analysis and clinical correlation of atypical apocrine lesions in breast pathology. Human Pathology 2026, 175: 106158. PMID: 42176994, DOI: 10.1016/j.humpath.2026.106158.Peer-Reviewed Original ResearchAtypical apocrine lesionsInvasive ductal carcinomaApocrine lesionsNuclear irregularityCribriform architectureDuctal carcinomaHistological featuresClinical correlatesBreast pathologyNuclear enlargementClinical follow-up dataAtypical ductal hyperplasiaFollow-up dataApocrine hyperplasiaDuctal hyperplasiaPatient ageNo significant differenceClinical outcomesApocrine adenosisApocrine changeClinical differencesClinical significanceNuclear featuresLesion sizeUpstagingDiagnosis of Ductal Carcinoma in Situ in Breast Biopsies for a Radiological Mass Lesion: Did We Miss Something?
Theriot J, Zhan H, Colón-Cartagena L, Lotfi P, Krishnamurti U, Liang Y. Diagnosis of Ductal Carcinoma in Situ in Breast Biopsies for a Radiological Mass Lesion: Did We Miss Something? International Journal Of Surgical Pathology 2026, 10668969261436010. PMID: 41944434, DOI: 10.1177/10668969261436010.Peer-Reviewed Original ResearchMass-forming lesionsInvasive carcinomaMass lesionPapillary carcinomaStromal fibrosisHistological subtypesHistological predictorsNuclear gradeHistopathological featuresEstrogen receptorPredictors of invasive carcinomaDiagnosis of ductal carcinomaPresence of invasive carcinomaCarcinoma in situSolid papillary carcinomaNon-invasive tumorsPathologic-radiologic correlationPapillary DCISDuctal carcinomaSurgical outcomesBenign lesionsBreast biopsyImaging findingsDCISHistological features
2025
Invasive breast carcinoma in a patient with PHTS: a case report
Zhan H, Fischbach N, Lynch M, Liang Y, Krishnamurti U, Cohen P. Invasive breast carcinoma in a patient with PHTS: a case report. Diagnostic Pathology 2025, 20: 120. PMID: 41107919, PMCID: PMC12532417, DOI: 10.1186/s13000-025-01715-1.Peer-Reviewed Original ResearchConceptsPTEN hamartoma tumor syndromeAtypical ductal hyperplasiaHamartoma tumor syndromeTumor syndromeFamily historyBilateral palpable breast massesFocal atypical ductal hyperplasiaFamily history of cancerInvasive breast carcinomaPalpable breast massesEctopic breast tissueBloody nipple dischargeAxillary lymph nodesGermline pathogenic variantsHistory of cancerCase presentationWeInvasive carcinomaBreast carcinomaDuctal hyperplasiaMastectomy specimensNipple dischargeRight breastBenign papillomasMultiple biopsiesPapillary proliferationInfrequent HPV Infection in Colorectal Neuroendocrine Carcinoma: Molecular and Histologic Characteristics
Wang X, Zhong M, Zhang X, Liang Y. Infrequent HPV Infection in Colorectal Neuroendocrine Carcinoma: Molecular and Histologic Characteristics. Diagnostics 2025, 15: 2569. PMID: 41153242, PMCID: PMC12562367, DOI: 10.3390/diagnostics15202569.Peer-Reviewed Original ResearchHigh-risk human papillomavirusSmall cell neuroendocrine carcinomaCell neuroendocrine carcinomaColorectal neuroendocrine carcinomaNeuroendocrine carcinomaPlatinum-based chemotherapyHigh-risk HPVHigh risk human papillomavirus statusHigh-risk human papillomavirus testingAssociated with high-risk human papillomavirusOncogenic mutationsMethods:Molecular profilingResults:Rectal neuroendocrine carcinomaComprehensive molecular profilingOptimal treatment strategyLong-term survivorsHPV infectionAggressive tumorsP16 expressionHuman papillomavirusClinical outcomesLonger survivalSurrogate markerAutoimmune Hepatitis and Overlapping Syndrome
Liang Y, Zhang X. Autoimmune Hepatitis and Overlapping Syndrome. Practical Anatomic Pathology 2025, 171-185. DOI: 10.1007/978-3-031-97506-6_11.ChaptersAutoimmune hepatitisInterface hepatitisPost-infantile giant cell hepatitisAutoimmune hepatitis overlap syndromeDiagnostic criteriaDrug-induced liver injuryType 2 AIHHistological diagnostic criteriaPresence of autoantibodiesGiant cell hepatitisProgressive liver diseaseLobular hepatitisClinical presentationLaboratory findingsHyaline globulesOverlap syndromeHistological findingsHepatocyte rosettesLiver injuryLiver diseasePathological featuresLymphoplasmacytic inflammationHepatitisInterobserver agreement and histologic analysis of atypical ductal hyperplasia bordering on ductal carcinoma in situ: A multi-institutional study
Korie U, Ai D, Podany P, Zhang H, Zhan H, Kahila M, Colon-Cartagena L, Wei S, Sun H, Du J, Krishnamurti U, Liang Y. Interobserver agreement and histologic analysis of atypical ductal hyperplasia bordering on ductal carcinoma in situ: A multi-institutional study. American Journal Of Clinical Pathology 2025, 164: 704-711. PMID: 40994034, DOI: 10.1093/ajcp/aqaf088.Peer-Reviewed Original ResearchConceptsDuctal carcinoma in situAtypical ductal hyperplasiaCarcinoma in situSpindle-shaped nucleiAssociated with carcinomaIndividual histologic featuresHistological featuresInterobserver agreementDuctal hyperplasiaBreast pathologistsBiopsy casesCases of atypical ductal hyperplasiaLow-grade ductal carcinoma in situEpithelial cellsClinical follow-up dataLesion extentHistological analysisDiagnostic gray zoneMulti-institutional studyVariable interobserver agreementFollow-up dataModerate to substantial agreementDuct involvementHistologic reviewRadiological findingsEstrogen receptor conversion in bone, liver and lung metastases from breast cancer
Podany P, Zhan H, Ai D, Krishnamurti U, Liang Y. Estrogen receptor conversion in bone, liver and lung metastases from breast cancer. Pathology - Research And Practice 2025, 275: 156222. PMID: 40967162, DOI: 10.1016/j.prp.2025.156222.Peer-Reviewed Original ResearchER conversionPrimary tumorTumor gradeGrade of primary tumorAssociated with worse prognosisMetastasis to boneBreast cancer treatmentMetastatic sitesER-positiveMedian survivalTP53 mutationsLiver metastasesPR positivityPIK3CA mutationsReceptor conversionClinicopathological factorsLung metastasesWorse prognosisNo significant differenceTumor typesBreast cancerGenetic alterationsMetastasisPatient managementTumorPTEN inactivating mutations are associated with hormone receptor loss during breast cancer recurrence
Zhan H, Antony V, Tang H, Theriot J, Liang Y, Hui P, Krishnamurti U, DiGiovanna M. PTEN inactivating mutations are associated with hormone receptor loss during breast cancer recurrence. Breast Cancer Research And Treatment 2025, 211: 441-447. PMID: 40063317, DOI: 10.1007/s10549-025-07660-3.Peer-Reviewed Original ResearchConceptsPten inactivating mutationsBreast cancerER+/HER2- tumorsRecurrent tumorsER+/HER2- breast cancer patientsInactivating mutationsAssociated with worse clinical outcomesTreatment historyER+/HER2- breast cancerTriple negative phenotypeBreast cancer recurrenceBreast cancer patientsHormone receptor lossResultsThe average timeHR+ tumorsDistant recurrenceHR statusER expressionRecurrent diseaseTumor histologyTumor recurrenceHER2 expressionHormone independencePatient ageClinicopathological characteristics
2024
Clinicopathologic Characteristics of MYC Copy Number Amplification in Breast Cancer
Sun T, Golestani R, Zhan H, Krishnamurti U, Harigopal M, Zhong M, Liang Y. Clinicopathologic Characteristics of MYC Copy Number Amplification in Breast Cancer. International Journal Of Surgical Pathology 2024, 33: 59-64. PMID: 38839260, DOI: 10.1177/10668969241256109.Peer-Reviewed Original ResearchBreast cancerCopy number amplificationClinicopathological characteristicsAssociation with TP53 mutation. InAssociated with invasive ductal carcinomaEstrogen receptor (ER)-negativeDisease-free survival timeGene copy number amplificationC-myc immunostainingNon-amplified tumorsTP53 mutationsTriple-negative statusMetastatic breast cancerInvasive ductal carcinomaMYC protein overexpressionBreast cancer patientsTriple-negativeDuctal carcinomaClinicopathological featuresGenetic abnormalitiesClinical dataImmunohistochemical studiesCancer patientsProtein overexpressionSurvival timeHistopathology and its clinical correlation of liver biopsy in patients with treated autoimmune hepatitis
Korie U, Joldoshova A, Khandakar B, Zhang X, Liang Y. Histopathology and its clinical correlation of liver biopsy in patients with treated autoimmune hepatitis. Annals Of Diagnostic Pathology 2024, 73: 152333. PMID: 38820911, DOI: 10.1016/j.anndiagpath.2024.152333.Peer-Reviewed Original ResearchConceptsAutoimmune hepatitisCo-existing diseasesTransaminase levelsLiver biopsyHistological featuresClinical correlatesDuctular reactionPeriportal fibrosisDiagnosis of autoimmune hepatitisHepatocyte injuryUntreated autoimmune hepatitisModerate portal inflammationModerate lobular inflammationSteroid therapyInterface hepatitisSteroid treatmentAIH groupPortal inflammationTreatment resistanceClinical featuresLobular inflammationBiopsyPatientsInflammationInjury features