Yilin Yang
Associate Research ScientistAbout
Research
Publications
2024
Interleukin-7-based identification of liver lymphatic endothelial cells reveals their unique structural features
Yang Y, Jeong J, Su T, Lai S, Zhang P, Garcia-Milian R, Graham M, Liu X, McConnell M, Utsumi T, Pereira J, Iwakiri Y. Interleukin-7-based identification of liver lymphatic endothelial cells reveals their unique structural features. JHEP Reports 2024, 6: 101069. PMID: 38966234, PMCID: PMC11222939, DOI: 10.1016/j.jhepr.2024.101069.Peer-Reviewed Original ResearchCell surface structuresLymphatic endothelial cellsPublished single-cell RNA-sequencingRNA-seq analysisScRNA-seq analysisSingle-cell RNA sequencingLymphatic systemEndothelial cellsInterleukin-7RNA-seqScRNA-seqExpressed genesRNA sequencingTranscriptomic changesLow abundanceI/R liver injuryGenesIsolation protocolLiver cell typesCell typesIsolation methodLiver of miceHuman liver specimensHeterozygous miceMouse liver
2023
An optimized visualization and quantitative protocol for in-depth evaluation of lymphatic vessel architecture in the liver
Jeong J, Tanaka M, Yang Y, Arefyev N, DiRito J, Tietjen G, Zhang X, McConnell M, Utsumi T, Iwakiri Y. An optimized visualization and quantitative protocol for in-depth evaluation of lymphatic vessel architecture in the liver. AJP Gastrointestinal And Liver Physiology 2023, 325: g379-g390. PMID: 37605828, PMCID: PMC10887843, DOI: 10.1152/ajpgi.00139.2023.Peer-Reviewed Original Research
2021
Alcohol-induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcohol-related liver disease
Yang Y, Sangwung P, Kondo R, Jung Y, McConnell MJ, Jeong J, Utsumi T, Sessa WC, Iwakiri Y. Alcohol-induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcohol-related liver disease. Journal Of Hepatology 2021, 75: 377-386. PMID: 33675874, PMCID: PMC8292196, DOI: 10.1016/j.jhep.2021.02.028.Peer-Reviewed Original ResearchConceptsEndothelial nitric oxide synthaseAlcohol-induced liver injuryLiver sinusoidal endothelial cellsAlcohol-related liver diseaseLiver injuryLSEC dysfunctionHsp90 acetylationNO productionHistone deacetylase 6Liver diseaseTherapeutic strategiesHeat shock protein 90 (Hsp90) acetylationLiver sinusoidal endothelial dysfunctionSinusoidal endothelial cell dysfunctionMouse liver sinusoidal endothelial cellsEndothelial cell dysfunctionNitric oxide synthaseEthanol-fed miceSinusoidal endothelial dysfunctionPotential therapeutic approachPotential therapeutic strategyNitric oxide productionNew therapeutic strategiesSinusoidal endothelial cellsAcetylation of Hsp90
2020
Single-Cell Transcriptomics Reveals Zone-Specific Alterations of Liver Sinusoidal Endothelial Cells in Cirrhosis
Su T, Yang Y, Lai S, Jeong J, Jung Y, McConnell M, Utsumi T, Iwakiri Y. Single-Cell Transcriptomics Reveals Zone-Specific Alterations of Liver Sinusoidal Endothelial Cells in Cirrhosis. Cellular And Molecular Gastroenterology And Hepatology 2020, 11: 1139-1161. PMID: 33340713, PMCID: PMC7903131, DOI: 10.1016/j.jcmgh.2020.12.007.Peer-Reviewed Original ResearchConceptsLiver sinusoidal endothelial cellsCirrhotic miceSinusoidal endothelial cellsLiver cirrhosisEndothelial cellsIntrahepatic vascular resistanceCarbon tetrachloride inhalationNovel therapeutic strategiesNitric oxide productionCirrhotic mouse liverEC populationsVascular resistanceClinical complicationsLiver fibrosisTherapeutic strategiesCirrhosisOxide productionEndocytic receptorMiceAbstractTextZone 3Extracellular matrix genesVascular ECsLymphatic ECsMouse liver
2018
Tanshinone IIA Activates Nuclear Factor-Erythroid 2-Related Factor 2 to Restrain Pulmonary Fibrosis via Regulation of Redox Homeostasis and Glutaminolysis
An L, Peng L, Sun N, Yang Y, Zhang X, Li B, Liu B, Li P, Chen J. Tanshinone IIA Activates Nuclear Factor-Erythroid 2-Related Factor 2 to Restrain Pulmonary Fibrosis via Regulation of Redox Homeostasis and Glutaminolysis. Antioxidants & Redox Signaling 2018, 30: 1831-1848. PMID: 30105924, DOI: 10.1089/ars.2018.7569.Peer-Reviewed Original ResearchConceptsPulmonary fibrosisRegulation of redox homeostasisMyofibroblast activationBinding of kelch-like ECH-associated protein 1Tan IIARedox homeostasisLungs of BLM-treated miceRegulation of nuclear factor erythroid 2-related factor 2BLM-treated miceReactive oxygen species (ROS)-mediated activationInhibitory effectEffects of Tan IIATanshinone IIATricarboxylic acid cycleNuclear factor erythroid 2-related factor 2Factor erythroid 2-related factor 2Function of Nrf2Extracellular matrix depositionMyofibroblast proliferationKelch-like ECH-associated protein 1Anaplerotic pathwaysCritical functionECH-associated protein 1Proteasomal degradationMyofibroblast transdifferentiationSuccinate induces aberrant mitochondrial fission in cardiomyocytes through GPR91 signaling
Lu Y, Li L, Yang Y, Yin X, Liu Q, Zhang L, Liu K, Liu B, Li J, Qi L. Succinate induces aberrant mitochondrial fission in cardiomyocytes through GPR91 signaling. Cell Death & Disease 2018, 9: 672. PMID: 29867110, PMCID: PMC5986788, DOI: 10.1038/s41419-018-0708-5.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAnimals, NewbornApoptosisDynaminsEnzyme ActivationExtracellular Signal-Regulated MAP KinasesGlucoseIsoproterenolMaleMice, Inbred ICRMitochondriaMitochondrial DynamicsMitochondrial ProteinsModels, BiologicalMyocardial IschemiaMyocytes, CardiacOxygenProtein Kinase C-deltaRatsReceptors, G-Protein-CoupledSignal TransductionSuccinic AcidConceptsMitochondrial fission factorMitochondrial fissionTranslocation of dynamin-related protein 1Dynamin-related protein 1Mitochondrial dysfunctionAberrant mitochondrial fissionExtracellular signal-regulated kinases-1/2Fission factorMitochondrial metabolismSignaling branchesExtracellular succinateSuccinate accumulationMitochondrial impairmentGPR91 signalingDrp1Protein 1MitochondriaSuccinateResponse to cardiac ischemiaOxygen-glucose deprivation-induced injuryG protein-coupled receptor 91ERK1/2Succinate releaseGPR91Cardiomyocyte apoptosis
2017
Ginsenoside Rg1 Inhibits Glucagon-Induced Hepatic Gluconeogenesis through Akt-FoxO1 Interaction
Liu Q, Zhang F, Zhang W, Pan A, Yang Y, Liu J, Li P, Liu B, Qi L. Ginsenoside Rg1 Inhibits Glucagon-Induced Hepatic Gluconeogenesis through Akt-FoxO1 Interaction. Theranostics 2017, 7: 4001-4012. PMID: 29109794, PMCID: PMC5667421, DOI: 10.7150/thno.18788.Peer-Reviewed Original ResearchConceptsSiRNA silencingPhosphoenolpyruvate carboxykinaseHepatic glucose productionActive-site mutantsEffect of Rg1Hepatic gluconeogenesisHormone glucagonHFD-fed miceRegulatory effectsSilencing of AktPyruvate tolerance testTolerance testGlucose productionMethods:Oral glucose tolerance testAkt inhibitor triciribineBinding to FOXO1Akt activationGlucose 6-phosphataseAkt phosphorylationPharmacological inhibitorsFoxO1 activityGlucose tolerance testHFD-fedSer473 siteSuccinate accumulation impairs cardiac pyruvate dehydrogenase activity through GRP91-dependent and independent signaling pathways: Therapeutic effects of ginsenoside Rb1
Li J, Yang Y, Li L, Zhang L, Liu Q, Liu K, Li P, Liu B, Qi L. Succinate accumulation impairs cardiac pyruvate dehydrogenase activity through GRP91-dependent and independent signaling pathways: Therapeutic effects of ginsenoside Rb1. Biochimica Et Biophysica Acta (BBA) - Molecular Basis Of Disease 2017, 1863: 2835-2847. PMID: 28736181, DOI: 10.1016/j.bbadis.2017.07.017.Peer-Reviewed Original ResearchConceptsPyruvate dehydrogenase kinase 4I/R injuryTherapeutic effectUpregulation of pyruvate dehydrogenase kinase 4Early interventionResistant to ischemia/reperfusion injuryPDH activitySuccinate accumulationHypoxia-inducible factor 1aPyruvate dehydrogenase kinase 4 expressionEffects of ginsenoside Rb1GPR91 signalingHypoxia/reoxygenation insultDiet-fed miceHigh-fat diet-fed miceIschemia/reperfusion injuryRelease of succinateCardiac ischemia/reperfusionRat heartsMetabolic disordersGinsenoside Rb1HIF-1aTrimetazidineExtracellular succinateIndependent signaling pathwaysGinsenoside Rg5 increases cardiomyocyte resistance to ischemic injury through regulation of mitochondrial hexokinase-II and dynamin-related protein 1
Yang Y, Li J, Liu K, Zhang L, Liu Q, Liu B, Qi L. Ginsenoside Rg5 increases cardiomyocyte resistance to ischemic injury through regulation of mitochondrial hexokinase-II and dynamin-related protein 1. Cell Death & Disease 2017, 8: e2625-e2625. PMID: 28230856, PMCID: PMC5386487, DOI: 10.1038/cddis.2017.43.Peer-Reviewed Original ResearchConceptsMitochondrial hexokinase-IIDynamin-related protein 1Binding to mitochondriaDrp1 recruitmentDrp1 activationHexokinase-IIDrp1 recruitment to mitochondriaTranslocation to mitochondriaRecruitment to mitochondriaOpening of mitochondrial permeability transition poreMitochondrial permeability transition porePermeability transition poreProtein 1Knockdown of AktSmall interfering RNAGinsenoside Rg5Mitochondrial fissionFatty-acid oxidationIschemic hearts of miceMitochondrial bindingDrp1Transition poreEffects of Rg5ATP productionMitochondrial functionGinsenoside Rg5 Inhibits Succinate-Associated Lipolysis in Adipose Tissue and Prevents Muscle Insulin Resistance
Xiao N, Yang L, Yang Y, Liu L, Li J, Liu B, Liu K, Qi L, Li P. Ginsenoside Rg5 Inhibits Succinate-Associated Lipolysis in Adipose Tissue and Prevents Muscle Insulin Resistance. Frontiers In Pharmacology 2017, 8: 43. PMID: 28261091, PMCID: PMC5306250, DOI: 10.3389/fphar.2017.00043.Peer-Reviewed Original ResearchER stressSuccinate accumulationMuscle insulin resistanceRg5 treatmentEndoplasmic reticulumPDE3B expressionNLRP3 inflammasome activationSuccinate dehydrogenaseInflammasome activationCellular energy chargeHigh-fat dietGinsenoside Rg5Regulation of lipidAdipose tissueCeramide accumulationAdipose dysfunctionInsulin resistanceMetabolic signalsCAMP/PKA activityHypoxic adipose tissueShort-term high-fat dietAdipose lipolysisInhibition of lipolysisGlucose homeostasisCAMP accumulation
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