Subhasis Mohanty, PhD
Research ScientistCards
About
Research
Publications
2026
Half a century of pneumococcal vaccination in sickle cell disease: Are we winning the battle or losing immunity?
Jamwal S, Omene B, Giri A, Rojas K, Mohanty S, Calhoun C, Krishnamurti L, Montgomery R, Shaw A, Andemariam B, Yildirim I. Half a century of pneumococcal vaccination in sickle cell disease: Are we winning the battle or losing immunity? Vaccine 2026, 88: 128866. PMID: 42322679, DOI: 10.1016/j.vaccine.2026.128866.Peer-Reviewed Original ResearchPneumococcal conjugate vaccineInvasive pneumococcal diseaseSickle cell diseasePneumococcal diseaseImmunological deficitsSerotype coverageConjugate vaccineRates of invasive pneumococcal diseaseEvolving epidemiologyCell diseaseContext of sickle cell diseaseVaccine-type invasive pneumococcal diseaseEpidemiology of pneumococcal diseaseNon-vaccine serotypesPneumococcal polysaccharide vaccineEvidence-based vaccination strategiesPersistent disease burdenPenicillin prophylaxisImmunocompromised populationsPneumococcal infectionClinical efficacyVaccine approachesSerotype replacementPneumococcal vaccinePolysaccharide vaccineAdaptive Immune Remodeling in Sickle Cell Disease: Linking Hemolysis-Driven Inflammation to Immune Dysfunction
Jamwal S, Mohanty S, Calhoun C, Krishnamurti L, Montgomery R, Shaw A, Yildirim I. Adaptive Immune Remodeling in Sickle Cell Disease: Linking Hemolysis-Driven Inflammation to Immune Dysfunction. Experimental Hematology 2026, 160: 105459. PMID: 42219144, DOI: 10.1016/j.exphem.2026.105459.Peer-Reviewed Original ResearchSickle cell diseaseDamage-associated molecular patternsImmune remodelingImmune dysfunctionHelper T cell polarizationAdaptive immunityMemory B cell compartmentCell diseaseTransfusion-related alloimmunizationImpaired vaccine responsesB cell compartmentBone marrow nicheT cell activationInnate immune activationAdult SCD populationT cell polarizationGerminal center dynamicsSusceptibility to infectionProgenitor cell fatePersistent hemolysisHematopoietic stemMarrow nicheImmune activationVaccine responseChronic inflammationExoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging
Mishra M, Kim H, Youm Y, Gonzalez-Hurtado E, Zaitsev K, Dlugos T, Shchukina I, Gliniak C, Ravussin E, Mohanty S, Shaw A, Scherer P, Artyomov M, Dixit V. Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging. Nature Aging 2026, 6: 1064-1078. PMID: 41974968, PMCID: PMC13190345, DOI: 10.1038/s43587-026-01107-0.Peer-Reviewed Original ResearchExtracellular signal-regulated kinaseCaloric restrictionComplement pathwayPhospholipase A2 group VIIAge-related inflammationSignal-regulated kinaseCALERIE trialFibroblast growth factor 21Macrophage subsetsVisceral fatReduce inflammagingAutocrine signalingC3a/C3 ratioPlasma samplesMiceInflammagingInflammationEffects of CRAgeGroup VIIC3aComplementHuman agingDiverse organismsPathway
2025
Unravelling the Immunological Enigma of Sickle Cell Disease: Current Understanding and Future Directions
Jamwal S, Calhoun C, Mohanty S, Montgomery R, Krishnamurti L, Shaw A, Yildirim I. Unravelling the Immunological Enigma of Sickle Cell Disease: Current Understanding and Future Directions. Immunology 2025, 177: 445-456. PMID: 41387179, PMCID: PMC12826409, DOI: 10.1111/imm.70080.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMemory B cellsSickle cell diseaseImmune dysregulationT cellsB cellsChronic inflammationImmunological enigmaImmune activationClass-switched memory B cellsAntigen-specific T cell responsesAntigen-specific T cellsImmune responseCell diseaseAntigen-specific immune activationAntigen-specific immune responsesImmune-targeted therapiesSickle cell disease patientsT-cell countsT-cell abnormalitiesT-cell phenotypeMemory B cell differentiationT cell responsesB cell compartmentAdaptive immune dysfunctionSickle cell disease pathophysiologyExoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging.
Mishra M, Kim HH, Youm YH, Gonzalez-Hurtado E, Zaitsev K, Dlugos T, Shchukina I, Gliniak C, Ravussin E, Mohanty S, Shaw AC, Scherer PE, Artyomov MN, Dixit VD. Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging. BioRxiv 2025 PMID: 40799539, DOI: 10.1101/2025.08.04.668533.Publications for non-academic audiencesMicrofluidics combined with electron microscopy for rapid and high-throughput mapping of antibody–viral glycoprotein complexes
Sewall L, de Paiva Froes Rocha R, Gibson G, Louie M, Xie Z, Bangaru S, Tran A, Ozorowski G, Mohanty S, Beutler N, Rogers T, Burton D, Shaw A, Batista F, Chocarro Ruiz B, Torrents de la Peña A, Ward A. Microfluidics combined with electron microscopy for rapid and high-throughput mapping of antibody–viral glycoprotein complexes. Nature Biomedical Engineering 2025, 9: 1938-1951. PMID: 40461656, PMCID: PMC12404239, DOI: 10.1038/s41551-025-01411-x.Peer-Reviewed Original ResearchStructure-based vaccine designVolumes of seraHA glycoproteinPolyclonal antibodiesImmune complexesAntibody responseVaccine designVaccine developmentHigh-throughput mappingCharacterization of immune complexesVaccinated individualsAntibodiesGlycoprotein complexViral glycoproteinsInvading pathogensEpitope mappingSeraSingle-particle electron microscopyGlycoproteinNegative-stain electron microscopyHormetic elevation of taurine restrains inflammaging by deactivating the NLRP3 inflammasome.
Guan C, Ryu S, Dong M, Youm YH, Mohanty S, Maeda R, Orliaguet L, Kim HH, Dlugos T, Smith SR, Ravussin E, Onyuru J, Wang A, Shaw AC, Hoffman HM, Kluger Y, Sugiura Y, Dixit VD. Hormetic elevation of taurine restrains inflammaging by deactivating the NLRP3 inflammasome. BioRxiv 2025 PMID: 40501605, DOI: 10.1101/2025.05.27.656381.Publications for non-academic audiences
2024
Plasma collagen neoepitopes are associated with multiorgan disease in the ACCESS and GRADS sarcoidosis cohorts
Sand J, Jessen H, Leeming D, Yu S, Lee C, Hu B, Sun Y, Adams T, Pivarnik T, Liu A, Woo S, McGovern J, Fiorini V, Saber T, Higuero-Sevilla J, Gulati M, Kaminski N, Damsky W, Shaw A, Mohanty S, Goobie G, Zhang Y, Herzog E, Ryu C. Plasma collagen neoepitopes are associated with multiorgan disease in the ACCESS and GRADS sarcoidosis cohorts. Thorax 2024, 79: 1136-1144. PMID: 39117421, PMCID: PMC12147189, DOI: 10.1136/thorax-2023-221095.Peer-Reviewed Original ResearchSarcoidosis cohortMultiorgan diseasePRO-C3Interleukin-4Case Control Etiologic Study of SarcoidosisPlasma levels of interleukin-4Alpha-1 antitrypsin deficiencyLevels of interleukin-4Pathogenesis of sarcoidosisC6MC3MHealthy control patientsStudy of sarcoidosisGenomic researchAbnormal extracellular matrixAssociated with dermatological diseaseCollagen degradationScadding stageCorticosteroid useComplex diseasesPRO-C6Control patientsIL-13IL-5IL-9
2023
Dectin-1 stimulation promotes a distinct inflammatory signature in the setting of HIV-infection and aging
Kumar A, Wang J, Esterly A, Radcliffe C, Zhou H, Wyk B, Allore H, Tsang S, Barakat L, Mohanty S, Zhao H, Shaw A, Zapata H. Dectin-1 stimulation promotes a distinct inflammatory signature in the setting of HIV-infection and aging. Aging 2023, 15: 7866-7908. PMID: 37606991, PMCID: PMC10497004, DOI: 10.18632/aging.204927.Peer-Reviewed Original ResearchConceptsDectin-1 stimulationDendritic cellsHIV-positive older adultsOlder adultsDectin-1 functionDistinct immune signaturesDistinct inflammatory signatureMonocytes of HIVCohort of HIVIFN-α productionPro-inflammatory environmentIFN-γ responsesPro-inflammatory phenotypeInnate immune receptorsDistinct gene signaturesStimulation of monocytesInflammatory signatureImmune signaturesHIV infectionIL-12Macrophage signatureCytokine productionIL-6Cytokine increaseHIVHigh-throughput single-cell profiling of B cell responses following inactivated influenza vaccination in young and older adults
Wang M, Jiang R, Mohanty S, Meng H, Shaw A, Kleinstein S. High-throughput single-cell profiling of B cell responses following inactivated influenza vaccination in young and older adults. Aging 2023, 15: 9250-9274. PMID: 37367734, PMCID: PMC10564424, DOI: 10.18632/aging.204778.Peer-Reviewed Original ResearchConceptsB cellsActivated B cellsB cell receptorOlder adultsInfluenza vaccinationAge groupsPeripheral blood B cellsYoung adultsInactivated influenza vaccineB cell responsesSubstantial disease burdenBlood B cellsMemory B cellsInfluenza vaccination responsesStrong antibody responseAge-related changesInfluenza vaccineVaccination responseSeasonal influenzaAntibody responseHospital visitsDisease burdenSomatic hypermutation frequenciesVaccinationCell responses