Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsRory Shallis, MD
Assistant Professor AdjunctAbout
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Titles
Assistant Professor Adjunct
Biography
Dr. Shallis received his MD from Rutgers-Robert Wood Johnson Medical School, completed his residency training at Brown University-Rhode Island Hospital and fellowship training at Yale-New Haven Hospital.
He is focused on the care and research of patients with myeloid malignancies, particularly acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). He also participated in the K12 Calabresi Immuno-Oncology Training Program and currently participates as an investigator in several clinical trials aimed at improving the outcomes of patients with AML and MDS.
Dr. Shallis also maintains research interest in epidemiological, outcomes and effectiveness research as it pertains to the hematologic malignancies with a goal of identifying barriers to effective care and ultimately strategies to improve the outcomes of patients with these malignant diseases. Dr. Shallis conducts research with the Cancer Outcomes, Public Policy and Effectiveness Research (COPPER) Center at Yale University.
Dr. Shallis has presented his research at multiple regional, national and international meetings and is a member of the National Comprehensive Cancer Network (NCCN) clinical guidelines for MDS and AML panels. He is an author on more than 75 peer-reviewed publications and book chapters, most of which as first author and has served as an ad hoc reviewer for many journals including Leukemia, Haematologica, Blood Advances, Leukemia Research, Leukemia & Lymphoma, Acta Haematologica, Hematology, Therapeutic Advances in Hematology, Expert Review of Hematology, BMC Hematology, eJHaem and Future Oncology among others.
Departments & Organizations
- Developmental Therapeutics
- Hematology
- Leukemia & Lymphoma Program
Education & Training
- Fellowship
- Yale - New Haven Hospital (2020)
- Internship
- Brown University - Rhode Island Hospital (2017)
- Residency
- Brown University - Rhode Island Hospital (2017)
- MD
- Rutgers University - Robert Wood Johnson Medical School (2014)
- BA
- Rutgers College, Cell Biology & Neuroscience Psychology (2010)
Research
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Overview
Medical Research Interests
ORCID
0000-0002-8542-2944
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Amer Zeidan, MBBS, MD
Jan Philipp Bewersdorf, MD, FACP
Nikolai Podoltsev, MD, PhD
Maximilian Stahl, MD
Lourdes Mendez, MD, PhD
Rong Wang, PhD
Myelodysplastic Syndromes
Myeloproliferative Disorders
Leukemia
Myelodysplastic-Myeloproliferative Diseases
Publications
2026
Cardiovascular Events in Patients With Acute Myeloid Leukemia Treated With Venetoclax A Multicenter Cohort Study
Filimon S, Ghamari A, Vakilpour A, Patel R, Achar R, Akhter N, Shallis R, DeCara J, Altman J, Smith A, Matthews A, Lai C, Brunner A, Farina K, Gilman H, Neilan T, Upadhyay D, Chittams J, Anazco F, Patel A, Tremblay D, Scherrer-Crosbie M. Cardiovascular Events in Patients With Acute Myeloid Leukemia Treated With Venetoclax A Multicenter Cohort Study. JACC Advances 2026, 5: 102821. PMID: 42312783, PMCID: PMC13308248, DOI: 10.1016/j.jacadv.2026.102821.Peer-Reviewed Original ResearchAltmetricNCCN Guidelines® Insights: Acute Myeloid Leukemia, Version 3.2026.
Pollyea D, Altman J, Assi R, Bachiashvili K, Bhatt V, Fathi A, Fedorov K, Foran J, Gojo I, Goldberg A, Hall A, Jonas B, Levine M, Mangan J, Mannis G, Marcucci G, Mims A, Moriarty K, Mustafa Ali M, Neff J, Nejati R, Olin R, Patel A, Percival M, Perl A, Pettit K, Rao D, Ravandi F, Schwabkey Z, Shallis R, Stahl M, Stone R, Thota S, Uy G, Walker A, Wang E, Awotiwon A, Roth S, Stehman K. NCCN Guidelines® Insights: Acute Myeloid Leukemia, Version 3.2026. Journal Of The National Comprehensive Cancer Network 2026, 24: 222-229. PMID: 42297017, DOI: 10.6004/jnccn.2026.0028.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAltmetricCost-effectiveness of frontline eltrombopag with immunosuppressive therapy for severe aplastic anemia
Ito S, Potnis K, Ng D, Patel K, Sra M, Shallis R, Podoltsev N, Kewan T, Stempel J, Mendez L, Huntington S, Stahl M, Zeidan A, Bewersdorf J, Goshua G. Cost-effectiveness of frontline eltrombopag with immunosuppressive therapy for severe aplastic anemia. Blood Red Cells & Iron 2026, 2: 100076. PMID: 42077391, PMCID: PMC13134686, DOI: 10.1016/j.brci.2026.100076.Peer-Reviewed Original ResearchThis study investigates how trainee-led teams developed updated consensus guidelines for managing peritoneal surface malignancies, demonstrating effective collaboration models for complex medical evidence synthesis.Predictors of complete molecular response and impact of allogeneic hematopoietic stem cell transplantation on outcome in patients with Philadelphia chromosome positive acute lymphoblastic leukemia (ALL): results from the Consortium on Myeloid Malignancies and Neoplastic Diseases (COMMAND)
Mohty R, Narra R, Mims A, Hunter C, Shallis R, Kota V, Jamy O, Coltoff A, Othman T, Jonas B, Patel A, DuVall A, Foucar C, Abdelsamia M, Palmisiano N, Patel S, Curran E, Omer Z, Advani A, Atallah E, Litzow M, Badar T. Predictors of complete molecular response and impact of allogeneic hematopoietic stem cell transplantation on outcome in patients with Philadelphia chromosome positive acute lymphoblastic leukemia (ALL): results from the Consortium on Myeloid Malignancies and Neoplastic Diseases (COMMAND). Leukemia & Lymphoma 2026, 67: 1587-1594. PMID: 41954351, DOI: 10.1080/10428194.2026.2650679.Peer-Reviewed Original ResearchThis study investigates predictors of complete molecular response (CMR) and shows that early CMR improves relapse-free survival in Philadelphia chromosome-positive acute lymphoblastic leukemia patients.Hypomethylating agents plus venetoclax versus intensive chemotherapy prior to transplant in high-risk acute myeloid leukemia.
Berton G, Bewersdorf J, Gilhodes J, Iat A, Soua A, DeAngelo D, Boussi L, Shallis R, Žučenka A, Bystrom R, Ling K, Aguirre L, Stone R, Luskin M, Garcia J, Winer E, Chen E, Wadleigh M, Mendez L, Podoltsev N, Tauveron-Jalenques U, Lanino L, Stein E, Zeidan A, Forcade E, Cluzeau T, Dumas P, Heiblig M, Devillier R, Shimony S, Goldberg A, Stahl M, Garciaz S. Hypomethylating agents plus venetoclax versus intensive chemotherapy prior to transplant in high-risk acute myeloid leukemia. Haematologica 2026 PMID: 41924924, DOI: 10.3324/haematol.2025.300202.Peer-Reviewed Original ResearchAltmetricCMML is in the eye of the be-WHO-lder: interrogating the newly proposed entity of oligomonocytic CMML: MDS or CMML?
Komrokji R, Komrokji Z, Al Ali N, Xie Z, Chan O, Kuykendall A, Walker A, Yun S, Reynolds S, Shallis R, Lancet J, Sallman D, Padron E. CMML is in the eye of the be-WHO-lder: interrogating the newly proposed entity of oligomonocytic CMML: MDS or CMML? Blood Neoplasia 2026, 3: 100224. PMID: 42232990, PMCID: PMC13223902, DOI: 10.1016/j.bneo.2026.100224.Peer-Reviewed Original ResearchAltmetricMechanistic overview and suggested strategies to overcome BCL-2 inhibitor resistance in TP53-mutated acute myeloid leukemia
Iqbal U, Shallis R. Mechanistic overview and suggested strategies to overcome BCL-2 inhibitor resistance in TP53-mutated acute myeloid leukemia. Frontiers In Cell And Developmental Biology 2026, 14: 1779094. PMID: 41929632, PMCID: PMC13038875, DOI: 10.3389/fcell.2026.1779094.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsPrognostic Model Combining Mutational and Cytogenetic Profiles in Acute Myeloid Leukemia Treated with Venetoclax and Hypomethylating Agents
Drekolias D, Zahra F, Fileni C, Sallman D, Mo Q, Chan O, Zhang L, Vincelette N, Yu X, Sammut R, Moon J, Park J, Umasangtongkul S, Lledo F, Razabdouski T, Cheng C, Qin D, Mai K, Ball S, Shallis R, Xie Z, Kuykendall A, Padron E, Sweet K, Walker A, Komrokji R, Lancet J, Niyongere S, Cluzeau T, Yun S. Prognostic Model Combining Mutational and Cytogenetic Profiles in Acute Myeloid Leukemia Treated with Venetoclax and Hypomethylating Agents. Blood Cancer Discovery 2026, 7: 403-413. PMID: 41671569, PMCID: PMC12967238, DOI: 10.1158/2643-3230.bcd-25-0193.Peer-Reviewed Original ResearchCitationsAltmetricHypomethylating agents plus venetoclax versus intensive chemotherapy in acute myeloid leukemia with chromosome 5 and 7 abnormalities.
Boussi L, Bewersdorf J, Liu Y, Shallis R, Aguirre L, Bystrom R, Zucenka A, Garciaz S, DeAngelo D, Stone R, Luskin M, Garcia J, Winer E, Chen E, Wadleigh M, Berton G, Ling K, Zeidan A, Stein E, Shimony S, Goldberg A, Stahl M. Hypomethylating agents plus venetoclax versus intensive chemotherapy in acute myeloid leukemia with chromosome 5 and 7 abnormalities. Haematologica 2026 PMID: 41609030, DOI: 10.3324/haematol.2025.288891.Peer-Reviewed Original ResearchThis study investigates the effectiveness of hypomethylating agents plus venetoclax versus intensive chemotherapy in acute myeloid leukemia with chromosome 5/7 abnormalities, showing comparable remission rates but emphasizing stem cell transplant for long-term survival.Comparative effectiveness of HMA with venetoclax vs intensive chemotherapy in AML with very high-risk cytogenetics
Aguirre L, Bewersdorf J, Liu Y, Shallis R, Boussi L, Zucenka A, Garciaz S, Bystrom R, DeAngelo D, Stone R, Luskin M, Garcia J, Winer E, Ling K, Chen E, Wadleigh M, Berton G, Stein E, Goldberg A, Mendez L, Zeidan A, Sallman D, Shimony S, Stahl M. Comparative effectiveness of HMA with venetoclax vs intensive chemotherapy in AML with very high-risk cytogenetics. Blood Neoplasia 2026, 3: 100201. PMID: 41859348, PMCID: PMC12997325, DOI: 10.1016/j.bneo.2026.100201.Peer-Reviewed Original ResearchCitations
Academic Achievements & Community Involvement
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Activities
activity National Comprehensive Cancer Network (NCCN) - Myelodysplastic Syndromes Guideline Panel
12/01/2020 - PresentCommitteesMemberactivity Older Adult AML Working Group - National Cancer Institute (NCI) Myeloid Precision Medicine Initiative
09/01/2020 - PresentPeer Review Groups and Grant Study SectionsMemberactivity ECOG-ACRIN Leukemia Committee
07/23/2020 - PresentCommitteesMemberactivity American Society of Hematology (ASH)
07/03/2017 - PresentProfessional OrganizationsMemberactivity American Society of Clinical Oncology (ASCO)
07/03/2017 - PresentProfessional OrganizationsMember
Honors
honor Top Overall Abstract
06/08/2020Regional AwardMyeloid Malignancies SymposiumDetailsUnited Stateshonor Hematology/Oncology Fellowship Program Research Award
06/01/2019Yale School of Medicine AwardYale Cancer CenterDetailsUnited States
News
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News
- December 13, 2024Source: OncLive
How Luspatercept Could Shake Up MDS Management—With Rory Shallis, MD
- November 26, 2024
Yale Cancer Center to Highlight Breakthroughs in Blood Cancers and Disorders at World’s Largest Hematology Meeting
- May 01, 2024
Yale Department of Internal Medicine Faculty Promotions and Appointments (May 2024)
- March 25, 2024
Yale’s Post ASH Review
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