Randy Luciano, MD, PhD
Associate Professor of MedicineCards
About
Research
Publications
2025
Urine mRNA Assay to Measure Compartment-Specific Kidney Injury
Barsotti G, Kumar A, Yi Z, Pell J, Tanvir E, Moledina D, Luciano R, Reghuvaran A, Meliambro K, Perincheri S, Zhang W, He J, Menon M. Urine mRNA Assay to Measure Compartment-Specific Kidney Injury. Journal Of The American Society Of Nephrology 2025, 36: 10.1681/asn.2025c7mvzqgd. DOI: 10.1681/asn.2025c7mvzqgd.Peer-Reviewed Original ResearchAssociation of Kidney Interstitial Infiltrate with and Without Tubulitis with Histological Acute Tubulointerstitial Nephritis
Mukherjee J, Sadarangani S, Shelton K, Shaw M, Liang C, Koval E, Kent C, Perazella M, Luciano R, Turner J, Moeckel G, Kuperman M, Rosenberg A, Kumar D, Wilson F, Parikh C, Moledina D. Association of Kidney Interstitial Infiltrate with and Without Tubulitis with Histological Acute Tubulointerstitial Nephritis. Journal Of The American Society Of Nephrology 2025, 36: 10.1681/asn.2025555bfcpt. DOI: 10.1681/asn.2025555bfcpt.Peer-Reviewed Original ResearchUrinary CXCL9 as a Predictive Biomarker of Corticosteroid Responsiveness in Acute Tubulointerstitial Nephritis
Sadarangani S, Obeid W, Moeckel G, Kuperman M, Kumar D, Rosenberg A, Perazella M, Turner J, Luciano R, Parikh C, Moledina D. Urinary CXCL9 as a Predictive Biomarker of Corticosteroid Responsiveness in Acute Tubulointerstitial Nephritis. Journal Of The American Society Of Nephrology 2025, 36: 10.1681/asn.20258762wsmf. DOI: 10.1681/asn.20258762wsmf.Peer-Reviewed Original ResearchAssociation of Kidney Biopsy Needle Gauge with Postprocedure Complications and Biopsy Adequacy
Staunton M, Garg K, Sadarangani S, Makhijani A, Shelton K, Koval E, Liang C, Shaw M, Kent C, Wilson F, Parikh C, Perazella M, Turner J, Luciano R, Moledina D. Association of Kidney Biopsy Needle Gauge with Postprocedure Complications and Biopsy Adequacy. Kidney360 2025, 6: 1682-1688. PMID: 40402808, DOI: 10.34067/kid.0000000835.Peer-Reviewed Original ResearchOdds of complicationsKidney biopsyOutcomes of blood transfusionBiopsy-related complicationsPropensity score weighting analysisBleeding risk factorsG biopsy needlePost-procedural complicationsScore-weighted analysisHemoglobin dropAngiographic interventionBlood transfusionPost-procedureComplication riskUnivariate analysisAssess safetyComposite outcomeDiagnostic adequacyBiopsy adequacyBiopsyG needleMultivariate analysisComplicationsRisk factorsNeedle gauge
2024
Risk vs. Reward: Impact of Kidney Biopsies on the Management of Critically Ill Patients
Llama A, Sadarangani S, Moledina D, Luciano R. Risk vs. Reward: Impact of Kidney Biopsies on the Management of Critically Ill Patients. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024dd7bnz12. DOI: 10.1681/asn.2024dd7bnz12.Peer-Reviewed Original ResearchThe Case | An active injection drug user with a skin rash and kidney failure
Aron A, Luciano R. The Case | An active injection drug user with a skin rash and kidney failure. Kidney International 2024, 105: 1327-1328. PMID: 38777409, DOI: 10.1016/j.kint.2024.03.009.Peer-Reviewed Original ResearchIdentification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis
Moledina D, Obeid W, Smith R, Rosales I, Sise M, Moeckel G, Kashgarian M, Kuperman M, Campbell K, Lefferts S, Meliambro K, Bitzer M, Perazella M, Luciano R, Pober J, Cantley L, Colvin R, Wilson F, Parikh C. Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis. Journal Of Clinical Investigation 2024, 134: e180583. PMID: 38488004, PMCID: PMC10940080, DOI: 10.1172/jci180583.Peer-Reviewed Original ResearchRationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis
Barsotti G, Luciano R, Kumar A, Meliambro K, Kakade V, Tokita J, Naik A, Fu J, Peck E, Pell J, Reghuvaran A, Tanvir E, Patel P, Zhang W, Li F, Moeckel G, Perincheri S, Cantley L, Moledina D, Wilson F, He J, Menon M. Rationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis. Kidney International Reports 2024, 9: 1354-1368. PMID: 38707807, PMCID: PMC11068976, DOI: 10.1016/j.ekir.2024.02.006.Peer-Reviewed Original ResearchMinimal change diseaseRandomized Controlled TrialsSafety of metforminDouble-blindPodocyte injuryAdjunctive therapyPlacebo-controlled randomized controlled trialsPhase III studyPhase II trialPrimary glomerular diseaseFocal segmental glomerulosclerosisEffect of metforminPhase IIPlacebo-ControlledPreclinical dataNovel urineChange diseaseTissue markersRandomized trialsSegmental glomerulosclerosisGlomerular diseaseMechanistic biomarkersObservational studyFSGSInexpensive agent
2023
Guillain-Barre Syndrome Presenting Alongside Lupus Nephritis: Case and Management
Mehta P, Luciano R, Aklilu A, Malvar G. Guillain-Barre Syndrome Presenting Alongside Lupus Nephritis: Case and Management. Journal Of The American Society Of Nephrology 2023, 34: 277-277. DOI: 10.1681/asn.20233411s1277a.Peer-Reviewed Original ResearchDiffuse Alveolar Hemorrhage Presenting in IgA Nephropathy
Jobson C, Luciano R, Shirali A, Malvar G. Diffuse Alveolar Hemorrhage Presenting in IgA Nephropathy. Journal Of The American Society Of Nephrology 2023, 34: 1119-1119. DOI: 10.1681/asn.20233411s11119a.Peer-Reviewed Original Research
Clinical Trials
Current Trials
Treating Kidney Disease in Patients with APOL1
HIC ID2000030942RoleSub InvestigatorPrimary Completion Date05/31/2026Recruiting ParticipantsGenderBothAge18 years - 60 years
Academic Achievements & Community Involvement
Clinical Care
Overview
Randy Luciano, MD, PhD, has expertise in treating patients with glomerular disease (a kind of kidney disease that affects the filtering aspect of the kidney) and kidney-related vasculitis. Additionally, Dr. Luciano treats patients with, but not limited to, minimal change disease, membranous nephropathy, FSGS, renal amyloidosis, Lupus nephritis, IgA nephropathy, and ANCA mediated vasculitis. He is directly involved in the diagnosis (through biopsy) and treatment of patients with glomerular disease. In addition, he coordinates several clinical trials to help further progress the treatment options for these diseases.
Clinical Specialties
Nephrology; Rheumatology
Fact Sheets
Polycystic Kidney Disease (PKD)
Learn More on Yale MedicineGlomerulonephritis
Learn More on Yale MedicineDiagnosing Lupus Nephritis
Learn More on Yale MedicineAcute Kidney Injury (AKI)
Learn More on Yale Medicine
Yale Medicine News
News
News
- August 26, 2025
Yale Department of Internal Medicine Faculty Promotions and Appointments (August 2025)
- July 25, 2025Source: Yale Medicine
Two Simple Tests That Can Help Detect Kidney Conditions Early
- April 24, 2024Source: Yale Medicine
Why Is Chronic Kidney Disease (CKD) on the Rise? 6 Things to Know
- September 14, 2023
Smilow Shares: AL Amyloidosis
Get In Touch
Contacts
Appointment Number
Administrative Support
Locations
Patient Care Locations
Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.