Mika Naganawa, PhD

2026

• Widespread synaptic density loss in schizophrenia follows molecular and network architecture

  Chopra S, Worhunsky P, Naganawa M, Zhang X, Segal A, Labache L, Orchard E, Cropley V, Wood S, Angarita G, Cosgrove K, Matuskey D, Nabulsi N, Huang Y, Carson R, Esterlis I, Skosnik P, D’Souza D, Holmes A, Radhakrishnan R. Widespread synaptic density loss in schizophrenia follows molecular and network architecture. Molecular Psychiatry 2026, 1-12. PMID: 42350786, DOI: 10.1038/s41380-026-03717-x.

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• Lower Muscarinic M1 Receptor Availability in Schizophrenia: In Vivo PET Evidence

  Volpi T, Radhakrishnan R, Hird R, Naganawa M, Nabulsi N, Najafzadeh S, Jacutin-Porte S, Labaree D, Carson R, Huang Y, D'Souza D. Lower Muscarinic M1 Receptor Availability in Schizophrenia: In Vivo PET Evidence. Biological Psychiatry 2026 PMID: 42285196, DOI: 10.1016/j.biopsych.2026.06.002.

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• Optimization of brain PET markerless head motion correction in a large human cohort

  Zeng T, Zhang J, Gallezot J, Fontaine K, Jiang W, Gravel P, Mulnix T, Naganawa M, Yang Z, Zhang X, Wang S, Sun X, Hu L, Carson R. Optimization of brain PET markerless head motion correction in a large human cohort. EJNMMI Physics 2026 PMID: 42213388, DOI: 10.1186/s40658-026-00885-1.

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• 24. Lower Striatal HDAC6 in Individuals With Alcohol Use Disorder

  Bonomi R, Naganawa M, Zakiniaeiz Y, Huang Y, Matuskey D, Cosgrove K. 24. Lower Striatal HDAC6 in Individuals With Alcohol Use Disorder. Biological Psychiatry 2026, 99: s109-s110. DOI: 10.1016/j.biopsych.2026.03.258.

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• 596. Links Between Kappa Opioid Receptor Availability, Boredom, Impulsivity, and the Salience Network: An In-Vivo Investigation

  Weiss E, Hart-Derrick V, Freeman D, Miller R, Naganawa M, Duraney E, Davis M. 596. Links Between Kappa Opioid Receptor Availability, Boredom, Impulsivity, and the Salience Network: An In-Vivo Investigation. Biological Psychiatry 2026, 99: s354-s355. DOI: 10.1016/j.biopsych.2026.03.830.

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• 553. In-Vivo Investigation of Kappa Opioid Receptor Availability, Interoceptive Awareness, Disordered Eating Behaviors Using [11C]EKAP Pet

  Li X, Weiss E, Hart-Derrick V, Freeman D, Miller R, Naganawa M, Davis M. 553. In-Vivo Investigation of Kappa Opioid Receptor Availability, Interoceptive Awareness, Disordered Eating Behaviors Using [11C]EKAP Pet. Biological Psychiatry 2026, 99: s337. DOI: 10.1016/j.biopsych.2026.03.787.

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• 225. In Vivo Examination of the Kappa Opioid Receptor in Borderline Personality Disorder: Relationship to Restrictive Eating Cognitions and Behaviour

  Li R, Wong V, Naganawa M, Hart-Derrick V, Freeman D, Miller R, Weiss E, Davis M. 225. In Vivo Examination of the Kappa Opioid Receptor in Borderline Personality Disorder: Relationship to Restrictive Eating Cognitions and Behaviour. Biological Psychiatry 2026, 99: s195. DOI: 10.1016/j.biopsych.2026.03.459.

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• Lower synaptic density in mood circuitry underlies depression in Parkinson’s disease

  Cayir S, Naganawa M, Volpi T, Sadabad F, Dias M, Yang Y, Elliott S, Ansari M, Elshahat A, Pittman B, Esterlis I, Nabulsi N, Huang Y, Sanacora G, Comley R, Finnema S, Carson R, Tinaz S, Matuskey D, Holmes S. Lower synaptic density in mood circuitry underlies depression in Parkinson’s disease. Brain Communications 2026, 8: fcag136. PMID: 42109687, PMCID: PMC13152014, DOI: 10.1093/braincomms/fcag136.

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• Optimized reference region and the effect on test-retest reliability and sensitivity to differences between Parkinson’s disease and control groups with [11C]UCB-J

  Khattar N, Matuskey D, Gallezot J, Naganawa M, Holmes S, Sadabad F, Mayeli M, Esterlis I, van Dyck C, Mecca A, D’Souza D, Nabulsi N, Finnema S, Huang Y, Carson R, Toyonaga T. Optimized reference region and the effect on test-retest reliability and sensitivity to differences between Parkinson’s disease and control groups with [11C]UCB-J. Journal Of Cerebral Blood Flow And Metabolism : Official Journal Of The International Society Of Cerebral Blood Flow And Metabolism 2026, 0271678x261441071. PMID: 41960765, PMCID: PMC13068773, DOI: 10.1177/0271678x261441071.

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• Synaptic density imaging in behavioral variant frontotemporal dementia: A comparison of 18F‐SynVesT‐1 and 18F‐FDG PET

  Fesharaki‐Zadeh A, Cayir S, Ibrahim W, Yang Y, Gallezot J, Naganawa M, Wu Y, Toyonaga T, Sadabad F, O'Dell R, Pittman B, Nabulsi N, Strittmatter S, Carson R, Huang Y, van Dyck C, Mecca A, Matuskey D. Synaptic density imaging in behavioral variant frontotemporal dementia: A comparison of 18F‐SynVesT‐1 and 18F‐FDG PET. Alzheimer's & Dementia 2026, 22: e71283. PMID: 41954197, PMCID: PMC13063251, DOI: 10.1002/alz.71283.

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  This study investigates synaptic density imaging in behavioral variant frontotemporal dementia, showing that SV2A PET detects more pronounced synaptic loss than glucose hypometabolism using FDG PET, aiding early diagnosis and monitoring.

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