Maggie Taylor Davis, PhD
Associate Professor of PsychiatryCards
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Associate Professor of Psychiatry
Biography
Dr. Davis is a licensed clinical psychologist and Associate Professor in the Yale Department of Psychiatry, co-appointed in the Department of Psychology. As an emergent expert in trauma-and-stressor related conditions, her work seeks to identify neurobiological mechanisms underlying behavioral responses related to PTSD, borderline personality disorder and other forms of trauma related psychopathology (e.g. eating disorders, substance use), and their link to suicide behaviors and functional impairment. Specifically, using PET imaging and fMRI Dr. Davis aims to explore novel biomarkers and potential treatment targets with the potential to reduce risk in survivors of trauma. Her current K08, R21 and R01 grants (funded my NIMH) and Young Investigator grant from the American Foundation for Suicide Prevention (AFSP) investigate the role of endogenous glutamate and opioid systems on 1) trait markers for suicide behaviors, 2) molecular and behavioral differences across biological sex, and 3) whether these systems have further implications for the risk of opiate misuse and other forms of serious comorbidity in those living with BPD and PTSD.
Beyond her personal research projects, Maggie is a specialist with expertise and clinical experience in prolonged exposure, cognitive processing therapy, cognitive behavioral therapy (various protocols) and dialectical behavior therapy (DBT). She serves as the faculty lead for data integration and research management for the Yale New Haven Health Adult Behavioral Intensive Outpatient Program (IOP). Further, Dr. Davis participated in the piloting and validation of the two most widely used assessments for PTSD in the DSM-5 (PCL-5 and the CAPS-5). Dr. Davis commits her life’s work to serving and connecting those in distress to lifesaving interventions and resources. Her impact and experience in the field spans from the treatment of individuals coping with trauma and emotion dysregulation-related symptoms to the system-wide codification of such conditions.
Appointments
Psychiatry
Associate Professor on TermPrimaryDepartment of Psychology
Assistant ProfessorSecondary
Other Departments & Organizations
- Center for Brain & Mind Health
- Department of Psychology
- Janeway Society
- MR Core
- Psychiatry
- Translational Brain Imaging Program
- Yale Biomedical Imaging Institute
- Yale Instruction/Investigation/Intervention in Emotional Lability and Dysregulation (YIELD)
Education & Training
- Postdoctoral Fellow
- Yale University School of Medicine (2018)
- Predoctoral Intern
- University of Michigan/ VA Ann Arbor Healthcare System (2016)
- PhD
- Auburn University, Clinical Psychology (2016)
- MS
- Auburn University, Clinical Psychology (2013)
- BA
- University of Virginia, Psychology (2006)
Research
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Overview
Medical Research Interests
Public Health Interests
ORCID
0000-0001-7297-710X- View Lab Website
The UPLiFT Lab
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Irina Esterlis, PhD
Nicole DellaGioia
Ruth Asch
Nabeel Nabulsi, PhD
Richard Carson, PhD
David Matuskey, MD
Stress Disorders, Post-Traumatic
Positron-Emission Tomography
Suicide
Mental Disorders
Borderline Personality Disorder
Trauma and Stressor Related Disorders
Publications
2026
Good Enough Assessment: A Comparison of Brief Screener and Detailed Interview Assessments of Borderline Personality Disorder Symptoms in a Clinical Research Setting
Fernandes L, Davis M, Luo W, McAfee T, Jones K, Chandler G, Fineberg S. Good Enough Assessment: A Comparison of Brief Screener and Detailed Interview Assessments of Borderline Personality Disorder Symptoms in a Clinical Research Setting. Personality Disorders Theory Research And Treatment 2026, 10.1037/per0000771. PMID: 42133395, PMCID: PMC13178104, DOI: 10.1037/per0000771.Peer-Reviewed Original ResearchConceptsBorderline personality disorderSelf-report instrumentInterview assessmentClinical InterviewBorderline personality disorder symptomsBorderline personality disorder diagnosisPersonality disorder symptomsStructured Clinical InterviewSelf-report questionnairesPersonality disorderDisorder symptomsBrief screenersScreening instrumentScreening interviewResearch participantsScreening toolInterview scoresClinical research settingResearch settingsScreenerPhone screenPotential research participantsSymptom experienceLevel of trainingParticipants596. Links Between Kappa Opioid Receptor Availability, Boredom, Impulsivity, and the Salience Network: An In-Vivo Investigation
Weiss E, Hart-Derrick V, Freeman D, Miller R, Naganawa M, Duraney E, Davis M. 596. Links Between Kappa Opioid Receptor Availability, Boredom, Impulsivity, and the Salience Network: An In-Vivo Investigation. Biological Psychiatry 2026, 99: s354-s355. DOI: 10.1016/j.biopsych.2026.03.830.Peer-Reviewed Original Research553. In-Vivo Investigation of Kappa Opioid Receptor Availability, Interoceptive Awareness, Disordered Eating Behaviors Using [11C]EKAP Pet
Li X, Weiss E, Hart-Derrick V, Freeman D, Miller R, Naganawa M, Davis M. 553. In-Vivo Investigation of Kappa Opioid Receptor Availability, Interoceptive Awareness, Disordered Eating Behaviors Using [11C]EKAP Pet. Biological Psychiatry 2026, 99: s337. DOI: 10.1016/j.biopsych.2026.03.787.Peer-Reviewed Original Research225. In Vivo Examination of the Kappa Opioid Receptor in Borderline Personality Disorder: Relationship to Restrictive Eating Cognitions and Behaviour
Li R, Wong V, Naganawa M, Hart-Derrick V, Freeman D, Miller R, Weiss E, Davis M. 225. In Vivo Examination of the Kappa Opioid Receptor in Borderline Personality Disorder: Relationship to Restrictive Eating Cognitions and Behaviour. Biological Psychiatry 2026, 99: s195. DOI: 10.1016/j.biopsych.2026.03.459.Peer-Reviewed Original ResearchMedication status is associated with metabotropic glutamate receptor 5 availability in bipolar disorder and with measures of attention, anhedonia, and cognition
Moisieienko K, Asch R, Davis M, DellaGioia N, Boster S, Pietrzak R, Esterlis I. Medication status is associated with metabotropic glutamate receptor 5 availability in bipolar disorder and with measures of attention, anhedonia, and cognition. Journal Of Affective Disorders 2026, 408: 121888. PMID: 42055136, DOI: 10.1016/j.jad.2026.121888.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsBipolar disorderUnmedicated BDHealthy controlsAssociated with poorer executive functionClinical assessment of depressionDorsolateral prefrontal (DLPFC) corticesPositron emission tomographyMetabotropic glutamate receptor subtype 5Medical statusDepressive symptom severityMeasures of attentionPoorer executive functionAssessment of depressionPsychiatric medication useSignificant group effectExecutive functionCannabis useCognitive symptomsAttention difficultiesNicotine useClinical assessmentNeuropsychiatric conditionsSymptom severityAnalysis of covarianceGlutamatergic mechanisms
2025
In vivo evidence for metabotropic glutamate receptor 5 dysregulation in chronic pain
Davis M, Weiss E, DellaGioia N, Boster S, Asch R, Moisieienko K, Esterlis I. In vivo evidence for metabotropic glutamate receptor 5 dysregulation in chronic pain. Neuropsychopharmacology 2025, 51: 799-806. PMID: 41413678, PMCID: PMC12932697, DOI: 10.1038/s41386-025-02296-9.Peer-Reviewed Original ResearchCitationsAltmetricConceptsTransdiagnostic samplePositron emission tomographyMetabotropic glutamate receptor 5Sleep disturbanceChronic painGlutamate receptor 5Associated with depressionSample of individualsSources of personalityPsychiatric groupsExecutive dysfunctionAcute painPsychiatric diagnosisBrain regionsCognitive functionMGlu5Severe depressionNeurophysiology of painEffective treatment optionTreatment targetExploratory analysisAnxietyDepressionEmission tomographyIn vivo evidenceValid Use of the Tonic Immobility Scale With Consideration of Peritraumatic Substance Use: Analysis of Item Differences and Measurement Invariance
Anderson R, Schaffer M, Davis M, Bennett D, Epshteyn G, Sexton M. Valid Use of the Tonic Immobility Scale With Consideration of Peritraumatic Substance Use: Analysis of Item Differences and Measurement Invariance. Psychological Trauma Theory Research Practice And Policy 2025, 10.1037/tra0002058. PMID: 41248051, PMCID: PMC12626386, DOI: 10.1037/tra0002058.Peer-Reviewed Original ResearchConceptsTonic Immobility ScaleExperience of TIMeasurement invarianceSubstance useBetween-group t-testsTonic immobilityAssociated with substance useSexual assault historyFreezing responseBelief endorsementAssault historyConfigural invarianceInvariance testingPerceived substance useSexual assaultBetween-groupInvariant modelAssaultThe Transdiagnostic Role of Boredom Within Personality Disorder Symptoms and Risk-Related Behaviors: Implications for Dialectical Behavior Therapy
Weiss E, Mullens S, Todman M, Barnes S, Lord K, Davis M. The Transdiagnostic Role of Boredom Within Personality Disorder Symptoms and Risk-Related Behaviors: Implications for Dialectical Behavior Therapy. Journal Of Psychotherapy Integration 2025, 36: 94-108. PMID: 41675295, PMCID: PMC12889986, DOI: 10.1037/int0000379.Peer-Reviewed Original ResearchCitationsConceptsBorderline personality disorderAntisocial personality disorderDialectical behavior therapyPersonality disorderBoredom pronenessTransdiagnostic roleBehavioral therapyBorderline personality disorder symptomsAntisocial personality disorder traitsDialectical behavior therapy programBorderline symptom severityPersonality disorder symptomsSevere BPD symptomsNegative mental health outcomesBehavioral therapy programEvidence-based treatmentsMental health outcomesBPD symptomsPersonality psychopathologyPersonality functioningDisorder symptomsSelf-injurySuicidal ideationPsychiatric conditionsRisk-related behaviorsVeterans with co-occurring PTSD and BPD symptoms benefit from dialectical behavior therapy: effects of PTSD on BPD symptom trajectories
Schreiber A, Davis M, Cawood C. Veterans with co-occurring PTSD and BPD symptoms benefit from dialectical behavior therapy: effects of PTSD on BPD symptom trajectories. Cognitive Behaviour Therapy 2025, ahead-of-print: 1-15. PMID: 41084836, DOI: 10.1080/16506073.2025.2572480.Peer-Reviewed Original ResearchCitationsConceptsBorderline personality disorder symptomsBorderline personality disorderDialectical behavior therapyPosttraumatic stress disorderBehavioral therapyTreatment engagementBorderline personality disorder symptom severityEffects of posttraumatic stress disorderDialectical behavior therapy treatmentComorbid posttraumatic stress disorderPosttraumatic stress disorder diagnosisTreatment outcomesPersonality disorderEmotion regulationStress disorderSymptom reductionSymptom severitySymptom trajectoriesBaseline severityDiagnostic profileVeteransVeterans Health AdministrationSymptomsDisordersSuicideExploring the influence of synaptic density and anxiety on pain perception: evidence from a [11C]UCB-J positron emission tomography imaging study
Moisieienko K, Asch R, Davis M, Pietrzak R, Esterlis I. Exploring the influence of synaptic density and anxiety on pain perception: evidence from a [11C]UCB-J positron emission tomography imaging study. The International Journal Of Neuropsychopharmacology 2025, 28: pyaf040. PMID: 40511849, PMCID: PMC12289550, DOI: 10.1093/ijnp/pyaf040.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexDorsolateral prefrontal cortexFusiform gyrusAnxiety symptomsSV2A densitySynaptic densityState anxietyMediation analysisPain sensitivityAssociated with greater pain sensitivityAssociated with painState anxiety symptomsFunctional brain alterationsMedically healthy subjectsIndirect effectsPrefrontal cortexCingulate cortexPlasma input functionBrain alterationsOne-tissue compartment modelPET imaging studiesGyrusAnxietyRegional volumesHigher pain sensitivity
Clinical Trials
Current Trials
Eligibility for Participation in Neuroimaging Studies
IRB ID2000027842RoleSub InvestigatorPrimary Completion Date12/31/2023Recruiting ParticipantsDysregulation in mGluR5 as a marker of BPD and suicide related endophenotypes
IRB ID2000023168RolePrincipal InvestigatorPrimary Completion Date10/31/2023Recruiting ParticipantsGenderBothAge18 years - 65 yearsAMPA Receptor Components of the Anti-Depressant Ketamine Response
IRB ID2000021345RoleSub InvestigatorPrimary Completion Date06/30/2032Recruiting ParticipantsGenderBothAge18 years - 65 yearsImaging mGluR5 and synaptic density in psychiatric disorders
IRB ID2000020186RoleSub InvestigatorPrimary Completion Date01/31/2018Recruiting ParticipantsGenderBothAge18 years - 80 years
Academic Achievements & Community Involvement
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Honors
honor Patterson Trust Mentored Research Award
02/28/2021Regional AwardRobert Leet and Clara Guthrie Patterson TrustDetailsUnited Stateshonor Loan Repayment Award (Clinical Research)
11/01/2019National AwardNIMHDetailsUnited Stateshonor Early Career Investigator Travel Fellowship Award
05/17/2019National AwardSociety for Biological PsychiatryDetailsUnited Stateshonor Yale Clinical Neuroimaging Conference Poster/ Presentation Award
02/14/2017Yale School of Medicine AwardYale UniversityDetailsUnited States
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