Inderjit Singh, MBChB, BMedSci, FRCP, FCCP, MD
Associate Professor TermCards
About
Research
Publications
2026
Beyond PVR: dynamic physiologic assessment enhances prognostic evaluation in pulmonary hypertension associated with chronic obstructive pulmonary disease
Tarras E, Yan X, Gange C, Kurz S, Joseph P, Singh I. Beyond PVR: dynamic physiologic assessment enhances prognostic evaluation in pulmonary hypertension associated with chronic obstructive pulmonary disease. BMJ Open Respiratory Research 2026, 13: e004192. PMID: 42303310, PMCID: PMC13289187, DOI: 10.1136/bmjresp-2026-004192.Peer-Reviewed Original ResearchStiff Left Atrial Syndrome: Hemodynamic Insights and a Noninvasive Diagnostic Approach
Haghani Rad N, Okasha O, Kwan J, Heerdt P, Singh I. Stiff Left Atrial Syndrome: Hemodynamic Insights and a Noninvasive Diagnostic Approach. Annals Of The American Thoracic Society 2026, aaoag163. PMID: 42295833, DOI: 10.1093/annalsats/aaoag163.Peer-Reviewed Original ResearchRight Ventricular End‐Ejection Pressure Predicts Mortality in Patients With Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction
Tarras E, Arun A, Joseph P, Heerdt P, Singh I. Right Ventricular End‐Ejection Pressure Predicts Mortality in Patients With Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction. Comprehensive Physiology 2026, 16: e70187. PMID: 42210677, DOI: 10.1002/cph4.70187.Peer-Reviewed Original ResearchComparative Pulmonary Artery Pressure Response between Large-Bore Thrombectomy and Catheter-Directed Thrombolysis in Patients with Intermediate-High- and High-Risk Pulmonary Embolism
Conte M, Khosla A, Singh I, Hur J, Pollak J, Mojibian H, Marino A, Heerdt P, Cornman-Homonoff J. Comparative Pulmonary Artery Pressure Response between Large-Bore Thrombectomy and Catheter-Directed Thrombolysis in Patients with Intermediate-High- and High-Risk Pulmonary Embolism. Journal Of Vascular And Interventional Radiology 2026, 37: 108863. PMID: 42177020, DOI: 10.1016/j.jvir.2026.108863.Peer-Reviewed Original ResearchReply to Sbarra et al.
Oakland H, Heerdt P, Hunter K, Singh I. Reply to Sbarra et al. AJP Heart And Circulatory Physiology 2026, 330: h1711-h1712. PMID: 42065598, DOI: 10.1152/ajpheart.00243.2026.Commentaries, Editorials and LettersPre-capillary Pulmonary Hypertension in a Patient with Interlobular Septal Thickening and Prominent Mediastinal Lymphadenopathy
Tarras E, Homer R, Singh I. Pre-capillary Pulmonary Hypertension in a Patient with Interlobular Septal Thickening and Prominent Mediastinal Lymphadenopathy. Annals Of The American Thoracic Society 2026, aaoag099. PMID: 42011712, DOI: 10.1093/annalsats/aaoag099.Peer-Reviewed Original ResearchSkin Transcriptomics Reveal Shared Molecular Mechanisms for Skin and Lung Involvement in Systemic Sclerosis
Zielonka J, Li N, Liu Y, Yan X, Wang Z, Ramirez M, Figueroa A, Korde A, Yin H, Britto C, Singh I, Sun H, Herzog E, Feghali‐Bostwick C, Hinchcliff M, Ryu C, Gomez J. Skin Transcriptomics Reveal Shared Molecular Mechanisms for Skin and Lung Involvement in Systemic Sclerosis. Arthritis & Rheumatology 2026 PMID: 41930625, DOI: 10.1002/art.70163.Peer-Reviewed Original Research3D echo derived right ventricular principal surface strain in pulmonary arterial hypertension
Oakland H, Bellumkonda L, Sugeng L, Joseph P, Kundu P, Izzi D, Zalik F, McCabe S, Raza A, Amendola R, Heerdt P, Hunter K, Singh I. 3D echo derived right ventricular principal surface strain in pulmonary arterial hypertension. AJP Heart And Circulatory Physiology 2026, 330: h729-h736. PMID: 41616802, PMCID: PMC13097151, DOI: 10.1152/ajpheart.00923.2025.Peer-Reviewed Original ResearchProximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging
De Man R, Cai Z, Doddaballapur P, Guerrera N, Regan A, Lin L, Schwarz E, Justet A, Abu Hussein N, Di Palo J, Cavinato C, Raredon M, Heerdt P, Singh I, Yan X, Kang M, Bruns D, Lee P, Tellides G, Humphrey J, Kaminski N, Ramachandra A, Manning E. Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging. Aging Cell 2026, 25: e70383. PMID: 41589414, PMCID: PMC12836046, DOI: 10.1111/acel.70383.Peer-Reviewed Original ResearchKnowledge Gaps and Controversies on Cardiopulmonary Exercise Testing in the Assessment of Pulmonary Vascular Disease: An Official Statement of the Pulmonary Vascular Research Institute Exercise and Right Ventricular Function Task Force
Waxman A, Babu A, Badagliacca R, Ferreira E, George P, Guazzi M, Howard L, Kim D, Kovacs G, Kubba S, Langleben D, McCabe C, Menezes T, Oliveira R, Orfanos S, Singh I, Systrom D, Tedford R, Vanderpool R, Vizza C, Rischard F. Knowledge Gaps and Controversies on Cardiopulmonary Exercise Testing in the Assessment of Pulmonary Vascular Disease: An Official Statement of the Pulmonary Vascular Research Institute Exercise and Right Ventricular Function Task Force. Pulmonary Circulation 2026, 16: e70240. PMID: 41586300, PMCID: PMC12824459, DOI: 10.1002/pul2.70240.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
Clinical Care
Overview
Inderjit Singh, MBChB, (a medical degree awarded in the United Kingdom) is director of the Pulmonary Vascular Disease Program and specializes in treating pulmonary hypertension (high blood pressure in the heart-to-lung system).
Dr. Singh was steered toward medicine at an early age while growing up in Malaysia, where his father was a pediatrician. He often accompanied his father to work and says he enjoyed watching him help others feel better.
During medical school, he was drawn to pulmonary medicine, within which he discovered pulmonary vascular medicine—and pulmonary hypertension in particular.
“I have a strong interest in understanding the right heart and how it interacts with the pulmonary circulation,” Dr. Singh says. “And I like how pulmonary hypertension overlaps with so many specialties from cardiology to rheumatology to hepatology. You need to know all the different organs and disease processes to understand pulmonary hypertension.”
Pulmonary hypertension is also an exciting field because of many advancements in treatment, he says. “For a long time, we didn’t have much to offer in terms of therapy. But now there is more understanding of the disease, so much so that now you have dedicated training programs for pulmonary hypertension,” he says.
For research, Dr. Singh explores how the right ventricle of the heart and the pulmonary circulation interact, particularly during exercise.
“Our research is mainly focused on how the right heart interacts with the lungs’ blood vessels at rest and during exercise,” he explains. “We are one of the few centers in the world that performs invasive cardiopulmonary exercise test (iCPET). We primarily perform iCPET for patients who have unexplained shortness of breath or fatigue. So, these are patients who've had all the routine investigative testing, all of which do not explain their symptoms.”
Clinical Specialties
Fact Sheets
Pulmonary Hypertension
Learn More on Yale MedicinePulmonary Embolism
Learn More on Yale MedicineAcute Respiratory Distress Syndrome (ARDS)
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Yale Medicine News
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News
- November 05, 2024
Yale Researchers at American Heart Association Scientific Session 2024
- July 24, 2024
Yale Department of Internal Medicine Faculty Promotions and Appointments (July 2024)
- April 27, 2023
Study Uncovers Reduced Exercise Tolerance and Other Changes in Long COVID
- February 21, 2022
Despite Recovering from COVID-19, Shortness of Breath Persists
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Pulmonary Vascular Disease Program
15 York Street, Lippard Laboratory for Clinical Investigation
NEW HAVEN, CT 06519
United States
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