Basavaraju G. Sanganahalli, PhD

I am a translational neuroscientist whose research integrates neurophysiology with advanced multimodal MRI to understand the biophysics of brain function and dysfunction. My expertise in combining fMRI, MRS, and DTI with electrophysiology and behavioral paradigms provides a unique framework to bridge neuronal activity, metabolism, and vascular responses across spatial and temporal scales. This integrative approach allows me to probe fundamental mechanisms of brain network organization and their disruption in disease.

My work focuses on uncovering the mechanistic basis of brain dysfunction and translating these findings into clinically relevant biomarkers. I apply this framework to study a broad spectrum of conditions, including healthy aging, Alzheimer’s disease, epilepsy, early life stress, schizophrenia, stroke, mild traumatic brain injury, and spinal cord injury. Through these studies, I aim to identify quantifiable, non-invasive biomarkers that enable early diagnosis, track disease progression, and assess therapeutic efficacy.

As Director of the Small Animal MRI Core, I lead the development of cutting-edge imaging methodologies and collaborative translational neuroscience programs. My long-term goal is to bridge basic and clinical research by advancing the next generation of imaging biomarkers that precisely capture neural circuit dynamics underlying brain health and disease.