Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsMatthias Tschoep, MD
About
Research
Publications
2026
GLP-1R–GIPR–PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice
Liskiewicz D, Novikoff A, Khalil A, Akindehin S, Campbell J, Candela P, Castelino R, Coupland C, Culot M, Dodson W, Douros J, Embring H, Feuchtinger A, Finan B, Garcia-Caceres C, Gao X, Gosselet F, Grandl G, Gutgesell R, Haas D, Jastroch M, Karaoglu E, Kakimoto P, Kaltenbach A, Keuper M, Kusminski C, Leander D, Liskiewicz A, Liu X, Maity-Kumar G, Martinez S, Mowery S, Nogueiras R, Paisley M, Perez-Tilve D, Petersen P, Pfluger P, Prakash S, Steffens S, Cebrian-Serrano A, Tost M, Wean J, Weber C, Yoshida J, Gerhart-Hines Z, Horvath T, Scherer P, Seeley R, DiMarchi R, Tschöp M, Krahmer N, Knerr P, Müller T. GLP-1R–GIPR–PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice. Nature 2026, 1-10. PMID: 42056522, DOI: 10.1038/s41586-026-10427-5.Peer-Reviewed Original ResearchGIPR:GCGR co-agonism restores normal weight in obese rodents
Perez-Tilve D, Zhang F, Zhang Y, Lohman K, Sorrell J, Vick A, Müller T, Tschöp M, DiMarchi R. GIPR:GCGR co-agonism restores normal weight in obese rodents. Molecular Metabolism 2026, 108: 102365. PMID: 41997446, PMCID: PMC13141540, DOI: 10.1016/j.molmet.2026.102365.Peer-Reviewed Original ResearchGlucagon-like receptor agonists and next-generation incretin-based medications: metabolic, cardiovascular, and renal benefits
Nauck M, Tuttle K, Tschöp M, Blüher M. Glucagon-like receptor agonists and next-generation incretin-based medications: metabolic, cardiovascular, and renal benefits. The Lancet 2026, 407: 892-908. PMID: 41547366, DOI: 10.1016/s0140-6736(25)02105-1.Peer-Reviewed Original Research
2025
Publisher Correction: GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice
Gutgesell R, Khalil A, Liskiewicz A, Maity-Kumar G, Novikoff A, Grandl G, Liskiewicz D, Coupland C, Karaoglu E, Akindehin S, Castelino R, Curion F, Liu X, Garcia-Caceres C, Cebrian-Serrano A, Douros J, Knerr P, Finan B, DiMarchi R, Sloop K, Samms R, Theis F, Tschöp M, Müller T. Publisher Correction: GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice. Nature Metabolism 2025, 7: 1299-1299. PMID: 40360757, PMCID: PMC12198006, DOI: 10.1038/s42255-025-01308-8.Peer-Reviewed Original ResearchGIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice
Gutgesell R, Khalil A, Liskiewicz A, Maity-Kumar G, Novikoff A, Grandl G, Liskiewicz D, Coupland C, Karaoglu E, Akindehin S, Castelino R, Curion F, Liu X, Garcia-Caceres C, Cebrian-Serrano A, Douros J, Knerr P, Finan B, DiMarchi R, Sloop K, Samms R, Theis F, Tschöp M, Müller T. GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice. Nature Metabolism 2025, 7: 1282-1298. PMID: 40301583, PMCID: PMC12198009, DOI: 10.1038/s42255-025-01294-x.Peer-Reviewed Original ResearchEstrogenic activity of E2-conjugated GLP-1 is mediated by intracellular endolysosomal acidification and estrone metabolism
Coupland C, Sun N, Khalil A, Karaoglu Ö, Liskiewicz A, Liskiewicz D, Grandl G, Akindehin S, Maity G, Yang B, Finan B, Knerr P, Douros J, Walch A, DiMarchi R, Tschöp M, Müller T, Novikoff A. Estrogenic activity of E2-conjugated GLP-1 is mediated by intracellular endolysosomal acidification and estrone metabolism. Molecular Metabolism 2025, 96: 102136. PMID: 40204014, PMCID: PMC12032945, DOI: 10.1016/j.molmet.2025.102136.Peer-Reviewed Original ResearchA once-daily GLP-1/GIP/glucagon receptor tri-agonist (NN1706) lowers body weight in rodents, monkeys and humans
Finan B, Douros J, Goldwater R, Hansen A, Hjerpsted J, Hjøllund K, Kankam M, Knerr P, Konkar A, Mowery S, Müller T, Nielsen J, Nygård S, Perez-Tilve D, Raun K, Yang B, Tschöp M, DiMarchi R. A once-daily GLP-1/GIP/glucagon receptor tri-agonist (NN1706) lowers body weight in rodents, monkeys and humans. Molecular Metabolism 2025, 96: 102129. PMID: 40139439, PMCID: PMC12051155, DOI: 10.1016/j.molmet.2025.102129.Peer-Reviewed Original ResearchRegulatory T cells in the mouse hypothalamus control immune activation and ameliorate metabolic impairments in high-calorie environments
Becker M, Kälin S, Neubig A, Lauber M, Opaleva D, Hipp H, Salb V, Ott V, Legutko B, Kälin R, Hippich M, Scherm M, Nascimento L, Serr I, Hosp F, Nikolaev A, Mohebiany A, Krueger M, Flachmeyer B, Pfaffl M, Haase B, Yi C, Dietzen S, Bopp T, Woods S, Waisman A, Weigmann B, Mann M, Tschöp M, Daniel C. Regulatory T cells in the mouse hypothalamus control immune activation and ameliorate metabolic impairments in high-calorie environments. Nature Communications 2025, 16: 2744. PMID: 40113758, PMCID: PMC11926360, DOI: 10.1038/s41467-025-57918-z.Peer-Reviewed Original ResearchGlucose-dependent insulinotropic polypeptide (GIP)
Müller T, Adriaenssens A, Ahrén B, Blüher M, Birkenfeld A, Campbell J, Coghlan M, D'Alessio D, Deacon C, DelPrato S, Douros J, Drucker D, Figueredo Burgos N, Flatt P, Finan B, Gimeno R, Gribble F, Hayes M, Hölscher C, Holst J, Knerr P, Knop F, Kusminski C, Liskiewicz A, Mabilleau G, Mowery S, Nauck M, Novikoff A, Reimann F, Roberts A, Rosenkilde M, Samms R, Scherer P, Seeley R, Sloop K, Wolfrum C, Wootten D, DiMarchi R, Tschöp M. Glucose-dependent insulinotropic polypeptide (GIP). Molecular Metabolism 2025, 95: 102118. PMID: 40024571, PMCID: PMC11931254, DOI: 10.1016/j.molmet.2025.102118.Peer-Reviewed Original ResearchDefinition and diagnostic criteria of clinical obesity
Rubino F, Cummings D, Eckel R, Cohen R, Wilding J, Brown W, Stanford F, Batterham R, Farooqi I, Farpour-Lambert N, le Roux C, Sattar N, Baur L, Morrison K, Misra A, Kadowaki T, Tham K, Sumithran P, Garvey W, Kirwan J, Fernández-Real J, Corkey B, Toplak H, Kokkinos A, Kushner R, Branca F, Valabhji J, Blüher M, Bornstein S, Grill H, Ravussin E, Gregg E, Al Busaidi N, Alfaris N, Al Ozairi E, Carlsson L, Clément K, Després J, Dixon J, Galea G, Kaplan L, Laferrère B, Laville M, Lim S, Luna Fuentes J, Mooney V, Nadglowski J, Urudinachi A, Olszanecka-Glinianowicz M, Pan A, Pattou F, Schauer P, Tschöp M, van der Merwe M, Vettor R, Mingrone G. Definition and diagnostic criteria of clinical obesity. The Lancet Diabetes & Endocrinology 2025, 13: 221-262. PMID: 39824205, PMCID: PMC11870235, DOI: 10.1016/s2213-8587(24)00316-4.Peer-Reviewed Original Research