Atorvastatin regulates pericardial patch healing via the microRNA140-ADAM10-ephrinB2 pathway.
Li X, Dardik A, Guo R, Zhang W, Xiang Y, Li S, Liu D, Shu C. Atorvastatin regulates pericardial patch healing via the microRNA140-ADAM10-ephrinB2 pathway. American Journal Of Translational Research 2018, 10: 4054-4064. PMID: 30662650, PMCID: PMC6325491.Peer-Reviewed Original ResearchPericardial patch angioplastyDose-dependent mannerPatch angioplastyPericardial patchMRNA expressionMiR-140 expressionADAM10 protein expressionDaily doseCardiovascular injuryVascular proceduresVascular surgeryEndothelium repairWistar ratsNeointimal formationNeointimal growthControl animalsEarly healingAtorvastatinCardiovascular systemStatin drugsWestern blotEphrinB2 expressionEphrinB2 mRNAProtein expressionAngioplasty