2004
The effect of preoperative antiplatelet therapy in coronary artery surgery: blood transfusion requirements for patients on cardiopulmonary bypass
Hekmat K, Menzel C, Kroener A, Schwinger R, Kampe S, Fischer U, Geissler H, Mehlhorn U. The effect of preoperative antiplatelet therapy in coronary artery surgery: blood transfusion requirements for patients on cardiopulmonary bypass. Current Medical Research And Opinion 2004, 20: 1429-1435. PMID: 15383191, DOI: 10.1185/030079904x2060.Peer-Reviewed Original ResearchConceptsAntiplatelet therapyCardiopulmonary bypassTransfusion requirementsControl patientsHomologous blood requirementsMediastinal tube drainagePreoperative antiplatelet therapyBlood transfusion requirementsCoronary artery bypassCoronary artery surgeryCoronary bypass surgeryFresh frozen plasma unitsAPT groupFrozen plasma unitsIntra-operative dataAPT therapyCON patientsElective CABGArtery bypassArtery surgeryBypass surgeryCommon complicationHospital dischargeTube drainageBlood lossMyocardial apoptosis prevention by radical scavenging in patients undergoing cardiac surgery
Fischer U, Tossios P, Huebner A, Geissler H, Bloch W, Mehlhorn U. Myocardial apoptosis prevention by radical scavenging in patients undergoing cardiac surgery. Journal Of Thoracic And Cardiovascular Surgery 2004, 128: 103-108. PMID: 15224028, DOI: 10.1016/j.jtcvs.2003.11.034.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcysteineAgedApoptosisCardiopulmonary BypassCaspase 3Caspase 7CaspasesCoronary Artery BypassCoronary Artery DiseaseDouble-Blind MethodEnzyme ActivationFemaleFree Radical ScavengersHeart RateHumansMaleMiddle AgedMyocardiumMyocytes, CardiacTreatment OutcomeVascular ResistanceVentricular Function, LeftVentricular PressureConceptsVentricular biopsy samplesN-acetylcysteineCardioplegic arrestBiopsy samplesCoronary artery bypass graft patientsLeft ventricular cardiac myocytesCardiac surgery patientsBypass graft patientsDouble-blind fashionConfidence intervalsCaspase-3Apoptosis inductionVentricular cardiac myocytesOxygen-derived speciesGraft patientsGray unitsSurgery patientsCardiac surgeryCardiopulmonary bypassClinical outcomesActive caspase-3Myocardial ischemiaApoptosis signal cascadePatientsCardiac myocytes
2001
Impact of myocardial protection during coronary bypass surgery on patient outcome
Mehlhorn U, Fattah M, Kuhn-Régnier F, Südkamp M, Geissler H, Raji M, Fischer U, de Vivie E. Impact of myocardial protection during coronary bypass surgery on patient outcome. Vascular 2001, 9: 482-486. PMID: 11489654, DOI: 10.1016/s0967-2109(01)00024-2.Peer-Reviewed Original ResearchConceptsCoronary artery surgeryConventional cardioplegiaArtery surgeryMyocardial protectionRenal failureNeurological symptomsPatient outcomesUltra-short acting beta-blocker esmololIntensive care unit stayPerioperative myocardial infarction ratePreoperative left ventricular functionRoutine coronary artery surgeryBeta-blocker esmololTotal hospital stayPostoperative renal failureCoronary bypass surgeryMyocardial infarction rateContinuous coronary perfusionLeft ventricular functionMyocardial protection techniquesIntensive care unitMechanical circulatory supportPositive inotropic medicationTime of mobilizationCardioplegia technique