2008
DISTRIBUTION OF NOS ISOFORMS IN A PORCINE ENDOTOXIN SHOCK MODEL
Doursout M, Oguchi T, Fischer U, Liang Y, Chelly B, Hartley C, Chelly J. DISTRIBUTION OF NOS ISOFORMS IN A PORCINE ENDOTOXIN SHOCK MODEL. Shock 2008, 29: 692-702. PMID: 17909454, PMCID: PMC3341620, DOI: 10.1097/shk.0b013e3181598b77.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCardiomyopathiesCoronary CirculationDisease Models, AnimalEnzyme ActivationEnzyme InhibitorsGene Expression Regulation, EnzymologicGuanidinesHemodynamicsHypotensionIsoenzymesLipopolysaccharidesNitric OxideNitric Oxide Synthase Type IINitric Oxide Synthase Type IIIOmega-N-MethylarginineOrgan SpecificityShock, SepticSwineVasoconstrictionVasodilationVasodilator AgentsConceptsCardiac depressionSeptic shockNOS inhibitorIsoform-specific NOS inhibitorsPorcine endotoxin shock modelNonspecific NOS inhibitorRegional hemodynamic parametersEndotoxin shock modelNovel therapeutic agentsDistribution of eNOSMesenteric vasoconstrictionRenal vasoconstrictionVasoconstrictor mediatorsEndogenous vasodilatorBlood pressureMyocardial depressionOrgan dysfunctionLPS infusionVascular toneEndotoxin administrationINOS activityHemodynamic parametersVascular bedHepatic vasodilationConscious pigs
2003
Nitrotyrosine and 8-isoprostane formation indicate free radical-mediated injury in hearts of patients subjected to cardioplegia
Mehlhorn U, Krahwinkel A, Geissler H, LaRosee K, Fischer U, Klass O, Suedkamp M, Hekmat K, Tossios P, Bloch W. Nitrotyrosine and 8-isoprostane formation indicate free radical-mediated injury in hearts of patients subjected to cardioplegia. Journal Of Thoracic And Cardiovascular Surgery 2003, 125: 178-183. PMID: 12539002, DOI: 10.1067/mtc.2003.97.Peer-Reviewed Original ResearchConceptsEnd of bypassCardiopulmonary bypassCyclic guanosine monophosphateMyocardial ischemiaIntermittent cold blood cardioplegiaConstitutive nitric oxide synthaseNitric oxide synthase activityNitric oxide synthase activationCyclic guanosine monophosphate contentOxygen-derived free radicalsCardiac myocytesCoronary endothelial injuryCoronary artery operationsFree radical-mediated lipid peroxidationCold blood cardioplegiaFree radical-mediated injuryGuanosine monophosphateHearts of patientsOxide synthase activityNitric oxide synthaseRadical-mediated lipid peroxidationVentricular biopsy specimensRadical-mediated injuryNitric oxide releaseBlood cardioplegia