2010
A Novel Physiologic Model for the Study of Abdominal Compartment Syndrome (ACS)
Shah S, Jimenez F, Walker P, Xue H, Uray K, Aroom K, Fischer U, Laine G, Stewart R, Norbury K, Cox C. A Novel Physiologic Model for the Study of Abdominal Compartment Syndrome (ACS). Journal Of Trauma And Acute Care Surgery 2010, 68: 682-689. PMID: 20220423, DOI: 10.1097/ta.0b013e3181c453cb.Peer-Reviewed Original ResearchConceptsAbdominal compartment syndromeMean arterial pressureHemorrhagic shock/resuscitationShock/resuscitationUrine outputInspiratory pressureAbdominal pressureDevelopment of ACSMesenteric venous hypertensionPulmonary artery pressureCentral venous pressureDamage control surgeryPeak inspiratory pressureLarge animal modelArtery pressureVenous hypertensionArterial pressureCompartment syndromeVenous pressureControl surgeryHemodynamic measurementsHemorrhagic shockAbdominal packingIntraperitoneal instillationBase excess
2009
Regulation of Endothelial Nitric Oxide Synthase (eNOS) in Myocardium Subjected to Cardioplegic Arrest
Fischer U, Klass O, Cox C, Stock U, Antonyan A, Brixius K, Fischer J, Mehlhorn U, Bloch W. Regulation of Endothelial Nitric Oxide Synthase (eNOS) in Myocardium Subjected to Cardioplegic Arrest. The Thoracic And Cardiovascular Surgeon 2009, 57: 379-385. PMID: 19795322, DOI: 10.1055/s-0029-1185873.Peer-Reviewed Original ResearchAnimalsCardiopulmonary BypassEnzyme ActivationFemaleHeart Arrest, InducedHeart VentriclesImmunohistochemistryMaleMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Models, AnimalMyocardial ContractionMyocardiumNitric Oxide Synthase Type IIIPhosphorylationProto-Oncogene Proteins c-aktSerineSwineThreonineTime FactorsVentricular Function, LeftIntravenous mesenchymal stem cell therapy for traumatic brain injury.
Harting M, Jimenez F, Xue H, Fischer U, Baumgartner J, Dash P, Cox C. Intravenous mesenchymal stem cell therapy for traumatic brain injury. Journal Of Neurosurgery 2009, 110: 1189-97. PMID: 19301973, PMCID: PMC2889620, DOI: 10.3171/2008.9.jns08158.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryMesenchymal stem cell therapyArterial circulationStem cell therapyWeeks postinfusionFunctional recoveryCell therapyPulmonary microvasculatureBrain injuryCortical impact traumatic brain injuryPulmonary first-pass effectImpact traumatic brain injuryIntravenous MSC therapyRecovery of motorCognitive function recoveryFirst-pass effectMeasurements of motorMSC infusionCerebral parenchymaFunction recoveryIntravenous infusionMSC therapyPreclinical promiseFunctional improvementCarotid artery
2008
DISTRIBUTION OF NOS ISOFORMS IN A PORCINE ENDOTOXIN SHOCK MODEL
Doursout M, Oguchi T, Fischer U, Liang Y, Chelly B, Hartley C, Chelly J. DISTRIBUTION OF NOS ISOFORMS IN A PORCINE ENDOTOXIN SHOCK MODEL. Shock 2008, 29: 692-702. PMID: 17909454, PMCID: PMC3341620, DOI: 10.1097/shk.0b013e3181598b77.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCardiomyopathiesCoronary CirculationDisease Models, AnimalEnzyme ActivationEnzyme InhibitorsGene Expression Regulation, EnzymologicGuanidinesHemodynamicsHypotensionIsoenzymesLipopolysaccharidesNitric OxideNitric Oxide Synthase Type IINitric Oxide Synthase Type IIIOmega-N-MethylarginineOrgan SpecificityShock, SepticSwineVasoconstrictionVasodilationVasodilator AgentsConceptsCardiac depressionSeptic shockNOS inhibitorIsoform-specific NOS inhibitorsPorcine endotoxin shock modelNonspecific NOS inhibitorRegional hemodynamic parametersEndotoxin shock modelNovel therapeutic agentsDistribution of eNOSMesenteric vasoconstrictionRenal vasoconstrictionVasoconstrictor mediatorsEndogenous vasodilatorBlood pressureMyocardial depressionOrgan dysfunctionLPS infusionVascular toneEndotoxin administrationINOS activityHemodynamic parametersVascular bedHepatic vasodilationConscious pigsMechanics of the left ventricular myocardial interstitium: effects of acute and chronic myocardial edema
Desai K, Laine G, Stewart R, Cox C, Quick C, Allen S, Fischer U. Mechanics of the left ventricular myocardial interstitium: effects of acute and chronic myocardial edema. AJP Heart And Circulatory Physiology 2008, 294: h2428-h2434. PMID: 18375722, DOI: 10.1152/ajpheart.00860.2007.Peer-Reviewed Original ResearchConceptsLeft ventricular chamber complianceMyocardial interstitial edemaChronic myocardial edemaInterstitial edemaMyocardial edemaMyocardial interstitiumChamber complianceCardiac functionCoronary sinus pressure elevationVentricular chamberDiastolic cardiac functionPulmonary artery bandingLeft ventricular chamberAcute myocardial edemaPressure-volume relationshipEdema formsEdematous heartInterstitial fibrosisPressure elevationAcute edemaChronic oedemaEdema resultsControl animalsEdemaInterstitial fluid pressure
2005
LIFEBRIDGE: A Portable, Modular, Rapidly Available “Plug-and-Play” Mechanical Circulatory Support System
Mehlhorn U, Brieske M, Fischer U, Ferrari M, Brass P, Fischer J, Zerkowski H. LIFEBRIDGE: A Portable, Modular, Rapidly Available “Plug-and-Play” Mechanical Circulatory Support System. The Annals Of Thoracic Surgery 2005, 80: 1887-1892. PMID: 16242474, DOI: 10.1016/j.athoracsur.2005.03.040.Peer-Reviewed Original ResearchConceptsExperimental safety evaluationMechanical circulatory support systemsPower supplyCirculatory support systemsPeripheral cannulationControl moduleAir embolizationTransport conditionsModular designCardiopulmonary bypass circuitBase modulePump flowModular constructionCentral cannulationAdequate perfusionPlugAir bolusBypass circuitElimination programModuleLifebridgeCannulationInitial evaluationDoppler devicePatient moduleResuscitation-Induced Gut Edema and Intestinal Dysfunction
Moore-Olufemi S, Xue H, Attuwaybi B, Fischer U, Harari Y, Oliver D, Weisbrodt N, Allen S, Moore F, Stewart R, Laine G, Cox C. Resuscitation-Induced Gut Edema and Intestinal Dysfunction. Journal Of Trauma And Acute Care Surgery 2005, 58: 264-270. PMID: 15706186, DOI: 10.1097/01.ta.0000133571.64393.d2.Peer-Reviewed Original ResearchConceptsMesenteric venous hypertensionGut edemaIntra-abdominal hypertensionVenous hypertensionIntestinal transitGroup BAltered gut barrier functionIschemia/reperfusion injuryBarrier functionGut barrier functionML/Mucosal injuryMyeloperoxidase activityFluid resuscitationIntestinal dysfunctionMucosal permeabilityReperfusion injurySham surgeryGut motilityGut functionHypertensionGroup AEdemaTissue resistanceInjury measurementsMild Hypothermia Impairs Left Ventricular Diastolic but Not Systolic Function
Fischer U, Cox C, Laine G, Mehlhorn U, Allen S. Mild Hypothermia Impairs Left Ventricular Diastolic but Not Systolic Function. Journal Of Investigative Surgery 2005, 18: 291-296. PMID: 16319049, DOI: 10.1080/08941930500327047.Peer-Reviewed Original ResearchConceptsPreload recruitable stroke workSystolic functionCardiopulmonary bypassCardiac outputCardioplegic arrestBody temperatureEarly post-CPB periodPost-CPB periodImpact of hypothermiaLeft ventricular functionRecruitable stroke workDP/Ventricular diastolicDiastolic functionCardiac dysfunctionVentricular functionLV diastolicHYPO groupCPB periodMyocardial protectionAnesthetized dogsMild hypothermiaStroke workLV micromanometerBaseline levels
2004
Effect of the Na+/H+ exchange inhibitor eniporide on cardiac performance and myocardial high energy phosphates in pigs subjected to cardioplegic arrest
Klass O, Fischer U, Perez E, Easo J, Bosse M, Fischer J, Tossios P, Mehlhorn U. Effect of the Na+/H+ exchange inhibitor eniporide on cardiac performance and myocardial high energy phosphates in pigs subjected to cardioplegic arrest. The Annals Of Thoracic Surgery 2004, 77: 658-663. PMID: 14759455, DOI: 10.1016/s0003-4975(03)01604-7.Peer-Reviewed Original ResearchMeSH KeywordsAdenine NucleotidesAnimalsCardiopulmonary BypassDose-Response Relationship, DrugEnergy MetabolismGlycogenGuanidinesHeart Arrest, InducedHemodynamicsMyocardial ContractionMyocardial Reperfusion InjuryPremedicationSodium-Hydrogen ExchangersSulfonesSwineVentricular Function, LeftWater-Electrolyte BalanceConceptsIschemia/reperfusionCardiopulmonary bypassCardioplegic arrestCrystalloid cardioplegic arrestCardiac performanceMyocardial adenine nucleotidesPreload recruitable stroke workMyocardial ischemia/reperfusionLeft ventricular isovolumic relaxationCold crystalloid cardioplegic arrestRecruitable stroke workMyocardial high-energy phosphatesHigh-energy phosphate contentHealthy pig heartsVentricular isovolumic relaxationAdenine nucleotidesRelevant pig modelHigh-energy phosphatesCardiac indexStandard hemodynamicsAcute studySystemic infusionStroke workVascular pressuresIsovolumic relaxationAward Article: Microcirculatory Society Award for Excellence in Lymphatic Research
COX C, FISCHER U, ALLEN S, LAINE G. Award Article: Microcirculatory Society Award for Excellence in Lymphatic Research. Microcirculation 2004, 11: 1-8. PMID: 15280094, DOI: 10.1080/10739680490266135.Peer-Reviewed Original ResearchConceptsMyocardial water contentMyocardial myeloperoxidaseMesenteric lymphMyocardial dysfunctionMyocardial edemaMesenteric ischemia/reperfusionPreload recruitable stroke workMin of reperfusionIschemia/reperfusionMin of ischemiaRecruitable stroke workLymph diversionMicrovascular alterationsCardiac dysfunctionCardiac outputMyocardial functionStroke workIsovolumic relaxationLymphSuperoxide releaseDysfunctionSuperoxide productionCanine groupReperfusionNormal canine
2003
Regional hypothermia reduces mucosal NF-κB and PMN priming via gut lymph during canine mesenteric Ischemia/Reperfusion1,2 1This paper was presented at the annual meeting of the Association for Academic Surgery, November 7–9, 2002, Boston, MA. 2Supported in part by NIGMS grants P50 GM38529-01, KO8 GM000675, and T32 GM08792.
Hassoun H, Fischer U, Attuwaybi B, Moore F, Safi H, Allen S, Cox C. Regional hypothermia reduces mucosal NF-κB and PMN priming via gut lymph during canine mesenteric Ischemia/Reperfusion1,2 1This paper was presented at the annual meeting of the Association for Academic Surgery, November 7–9, 2002, Boston, MA. 2Supported in part by NIGMS grants P50 GM38529-01, KO8 GM000675, and T32 GM08792. Journal Of Surgical Research 2003, 115: 121-126. PMID: 14572782, DOI: 10.1016/s0022-4804(03)00298-1.Peer-Reviewed Original ResearchConceptsTransvascular protein clearancePMN superoxide productionGut lymphIntraischemic hypothermiaNF-kappaB DNAProtein clearancePMN primingFistula modelRegional hypothermiaMesenteric ischemia/reperfusionSuperoxide productionPolymorphonuclear neutrophil (PMN) primingRemote organ injuryPro-inflammatory mediatorsMin of reperfusionEnd of ischemiaIschemia/reperfusionNF-kappaB activationNF-kappaB activityMesenteric ischemiaNeutrophil primingH reperfusionOrgan injuryReperfusion injuryMin reperfusionCardioplegic arrest induces apoptosis signal-pathway in myocardial endothelial cells and cardiac myocytes
Fischer U, Klass O, Stock U, Easo J, Geissler H, Fischer J, Bloch W, Mehlhorn U. Cardioplegic arrest induces apoptosis signal-pathway in myocardial endothelial cells and cardiac myocytes. European Journal Of Cardio-Thoracic Surgery 2003, 23: 984-990. PMID: 12829076, DOI: 10.1016/s1010-7940(03)00113-1.Peer-Reviewed Original Research