2008
Mechanics of the left ventricular myocardial interstitium: effects of acute and chronic myocardial edema
Desai K, Laine G, Stewart R, Cox C, Quick C, Allen S, Fischer U. Mechanics of the left ventricular myocardial interstitium: effects of acute and chronic myocardial edema. AJP Heart And Circulatory Physiology 2008, 294: h2428-h2434. PMID: 18375722, DOI: 10.1152/ajpheart.00860.2007.Peer-Reviewed Original ResearchConceptsLeft ventricular chamber complianceMyocardial interstitial edemaChronic myocardial edemaInterstitial edemaMyocardial edemaMyocardial interstitiumChamber complianceCardiac functionCoronary sinus pressure elevationVentricular chamberDiastolic cardiac functionPulmonary artery bandingLeft ventricular chamberAcute myocardial edemaPressure-volume relationshipEdema formsEdematous heartInterstitial fibrosisPressure elevationAcute edemaChronic oedemaEdema resultsControl animalsEdemaInterstitial fluid pressure
2004
Myocardial apoptosis prevention by radical scavenging in patients undergoing cardiac surgery
Fischer U, Tossios P, Huebner A, Geissler H, Bloch W, Mehlhorn U. Myocardial apoptosis prevention by radical scavenging in patients undergoing cardiac surgery. Journal Of Thoracic And Cardiovascular Surgery 2004, 128: 103-108. PMID: 15224028, DOI: 10.1016/j.jtcvs.2003.11.034.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcysteineAgedApoptosisCardiopulmonary BypassCaspase 3Caspase 7CaspasesCoronary Artery BypassCoronary Artery DiseaseDouble-Blind MethodEnzyme ActivationFemaleFree Radical ScavengersHeart RateHumansMaleMiddle AgedMyocardiumMyocytes, CardiacTreatment OutcomeVascular ResistanceVentricular Function, LeftVentricular PressureConceptsVentricular biopsy samplesN-acetylcysteineCardioplegic arrestBiopsy samplesCoronary artery bypass graft patientsLeft ventricular cardiac myocytesCardiac surgery patientsBypass graft patientsDouble-blind fashionConfidence intervalsCaspase-3Apoptosis inductionVentricular cardiac myocytesOxygen-derived speciesGraft patientsGray unitsSurgery patientsCardiac surgeryCardiopulmonary bypassClinical outcomesActive caspase-3Myocardial ischemiaApoptosis signal cascadePatientsCardiac myocytes