2010
A Novel Physiologic Model for the Study of Abdominal Compartment Syndrome (ACS)
Shah S, Jimenez F, Walker P, Xue H, Uray K, Aroom K, Fischer U, Laine G, Stewart R, Norbury K, Cox C. A Novel Physiologic Model for the Study of Abdominal Compartment Syndrome (ACS). Journal Of Trauma And Acute Care Surgery 2010, 68: 682-689. PMID: 20220423, DOI: 10.1097/ta.0b013e3181c453cb.Peer-Reviewed Original ResearchConceptsAbdominal compartment syndromeMean arterial pressureHemorrhagic shock/resuscitationShock/resuscitationUrine outputInspiratory pressureAbdominal pressureDevelopment of ACSMesenteric venous hypertensionPulmonary artery pressureCentral venous pressureDamage control surgeryPeak inspiratory pressureLarge animal modelArtery pressureVenous hypertensionArterial pressureCompartment syndromeVenous pressureControl surgeryHemodynamic measurementsHemorrhagic shockAbdominal packingIntraperitoneal instillationBase excess
2009
Regulation of Endothelial Nitric Oxide Synthase (eNOS) in Myocardium Subjected to Cardioplegic Arrest
Fischer U, Klass O, Cox C, Stock U, Antonyan A, Brixius K, Fischer J, Mehlhorn U, Bloch W. Regulation of Endothelial Nitric Oxide Synthase (eNOS) in Myocardium Subjected to Cardioplegic Arrest. The Thoracic And Cardiovascular Surgeon 2009, 57: 379-385. PMID: 19795322, DOI: 10.1055/s-0029-1185873.Peer-Reviewed Original ResearchAnimalsCardiopulmonary BypassEnzyme ActivationFemaleHeart Arrest, InducedHeart VentriclesImmunohistochemistryMaleMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Models, AnimalMyocardial ContractionMyocardiumNitric Oxide Synthase Type IIIPhosphorylationProto-Oncogene Proteins c-aktSerineSwineThreonineTime FactorsVentricular Function, Left
2008
DISTRIBUTION OF NOS ISOFORMS IN A PORCINE ENDOTOXIN SHOCK MODEL
Doursout M, Oguchi T, Fischer U, Liang Y, Chelly B, Hartley C, Chelly J. DISTRIBUTION OF NOS ISOFORMS IN A PORCINE ENDOTOXIN SHOCK MODEL. Shock 2008, 29: 692-702. PMID: 17909454, PMCID: PMC3341620, DOI: 10.1097/shk.0b013e3181598b77.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCardiomyopathiesCoronary CirculationDisease Models, AnimalEnzyme ActivationEnzyme InhibitorsGene Expression Regulation, EnzymologicGuanidinesHemodynamicsHypotensionIsoenzymesLipopolysaccharidesNitric OxideNitric Oxide Synthase Type IINitric Oxide Synthase Type IIIOmega-N-MethylarginineOrgan SpecificityShock, SepticSwineVasoconstrictionVasodilationVasodilator AgentsConceptsCardiac depressionSeptic shockNOS inhibitorIsoform-specific NOS inhibitorsPorcine endotoxin shock modelNonspecific NOS inhibitorRegional hemodynamic parametersEndotoxin shock modelNovel therapeutic agentsDistribution of eNOSMesenteric vasoconstrictionRenal vasoconstrictionVasoconstrictor mediatorsEndogenous vasodilatorBlood pressureMyocardial depressionOrgan dysfunctionLPS infusionVascular toneEndotoxin administrationINOS activityHemodynamic parametersVascular bedHepatic vasodilationConscious pigs
2005
LIFEBRIDGE: A Portable, Modular, Rapidly Available “Plug-and-Play” Mechanical Circulatory Support System
Mehlhorn U, Brieske M, Fischer U, Ferrari M, Brass P, Fischer J, Zerkowski H. LIFEBRIDGE: A Portable, Modular, Rapidly Available “Plug-and-Play” Mechanical Circulatory Support System. The Annals Of Thoracic Surgery 2005, 80: 1887-1892. PMID: 16242474, DOI: 10.1016/j.athoracsur.2005.03.040.Peer-Reviewed Original ResearchConceptsExperimental safety evaluationMechanical circulatory support systemsPower supplyCirculatory support systemsPeripheral cannulationControl moduleAir embolizationTransport conditionsModular designCardiopulmonary bypass circuitBase modulePump flowModular constructionCentral cannulationAdequate perfusionPlugAir bolusBypass circuitElimination programModuleLifebridgeCannulationInitial evaluationDoppler devicePatient module
2004
Effect of the Na+/H+ exchange inhibitor eniporide on cardiac performance and myocardial high energy phosphates in pigs subjected to cardioplegic arrest
Klass O, Fischer U, Perez E, Easo J, Bosse M, Fischer J, Tossios P, Mehlhorn U. Effect of the Na+/H+ exchange inhibitor eniporide on cardiac performance and myocardial high energy phosphates in pigs subjected to cardioplegic arrest. The Annals Of Thoracic Surgery 2004, 77: 658-663. PMID: 14759455, DOI: 10.1016/s0003-4975(03)01604-7.Peer-Reviewed Original ResearchMeSH KeywordsAdenine NucleotidesAnimalsCardiopulmonary BypassDose-Response Relationship, DrugEnergy MetabolismGlycogenGuanidinesHeart Arrest, InducedHemodynamicsMyocardial ContractionMyocardial Reperfusion InjuryPremedicationSodium-Hydrogen ExchangersSulfonesSwineVentricular Function, LeftWater-Electrolyte BalanceConceptsIschemia/reperfusionCardiopulmonary bypassCardioplegic arrestCrystalloid cardioplegic arrestCardiac performanceMyocardial adenine nucleotidesPreload recruitable stroke workMyocardial ischemia/reperfusionLeft ventricular isovolumic relaxationCold crystalloid cardioplegic arrestRecruitable stroke workMyocardial high-energy phosphatesHigh-energy phosphate contentHealthy pig heartsVentricular isovolumic relaxationAdenine nucleotidesRelevant pig modelHigh-energy phosphatesCardiac indexStandard hemodynamicsAcute studySystemic infusionStroke workVascular pressuresIsovolumic relaxation
2003
Cardioplegic arrest induces apoptosis signal-pathway in myocardial endothelial cells and cardiac myocytes
Fischer U, Klass O, Stock U, Easo J, Geissler H, Fischer J, Bloch W, Mehlhorn U. Cardioplegic arrest induces apoptosis signal-pathway in myocardial endothelial cells and cardiac myocytes. European Journal Of Cardio-Thoracic Surgery 2003, 23: 984-990. PMID: 12829076, DOI: 10.1016/s1010-7940(03)00113-1.Peer-Reviewed Original Research