2004
Effect of the Na+/H+ exchange inhibitor eniporide on cardiac performance and myocardial high energy phosphates in pigs subjected to cardioplegic arrest
Klass O, Fischer U, Perez E, Easo J, Bosse M, Fischer J, Tossios P, Mehlhorn U. Effect of the Na+/H+ exchange inhibitor eniporide on cardiac performance and myocardial high energy phosphates in pigs subjected to cardioplegic arrest. The Annals Of Thoracic Surgery 2004, 77: 658-663. PMID: 14759455, DOI: 10.1016/s0003-4975(03)01604-7.Peer-Reviewed Original ResearchMeSH KeywordsAdenine NucleotidesAnimalsCardiopulmonary BypassDose-Response Relationship, DrugEnergy MetabolismGlycogenGuanidinesHeart Arrest, InducedHemodynamicsMyocardial ContractionMyocardial Reperfusion InjuryPremedicationSodium-Hydrogen ExchangersSulfonesSwineVentricular Function, LeftWater-Electrolyte BalanceConceptsIschemia/reperfusionCardiopulmonary bypassCardioplegic arrestCrystalloid cardioplegic arrestCardiac performanceMyocardial adenine nucleotidesPreload recruitable stroke workMyocardial ischemia/reperfusionLeft ventricular isovolumic relaxationCold crystalloid cardioplegic arrestRecruitable stroke workMyocardial high-energy phosphatesHigh-energy phosphate contentHealthy pig heartsVentricular isovolumic relaxationAdenine nucleotidesRelevant pig modelHigh-energy phosphatesCardiac indexStandard hemodynamicsAcute studySystemic infusionStroke workVascular pressuresIsovolumic relaxationAward Article: Microcirculatory Society Award for Excellence in Lymphatic Research
COX C, FISCHER U, ALLEN S, LAINE G. Award Article: Microcirculatory Society Award for Excellence in Lymphatic Research. Microcirculation 2004, 11: 1-8. PMID: 15280094, DOI: 10.1080/10739680490266135.Peer-Reviewed Original ResearchConceptsMyocardial water contentMyocardial myeloperoxidaseMesenteric lymphMyocardial dysfunctionMyocardial edemaMesenteric ischemia/reperfusionPreload recruitable stroke workMin of reperfusionIschemia/reperfusionMin of ischemiaRecruitable stroke workLymph diversionMicrovascular alterationsCardiac dysfunctionCardiac outputMyocardial functionStroke workIsovolumic relaxationLymphSuperoxide releaseDysfunctionSuperoxide productionCanine groupReperfusionNormal canine
2003
Regional hypothermia reduces mucosal NF-κB and PMN priming via gut lymph during canine mesenteric Ischemia/Reperfusion1,2 1This paper was presented at the annual meeting of the Association for Academic Surgery, November 7–9, 2002, Boston, MA. 2Supported in part by NIGMS grants P50 GM38529-01, KO8 GM000675, and T32 GM08792.
Hassoun H, Fischer U, Attuwaybi B, Moore F, Safi H, Allen S, Cox C. Regional hypothermia reduces mucosal NF-κB and PMN priming via gut lymph during canine mesenteric Ischemia/Reperfusion1,2 1This paper was presented at the annual meeting of the Association for Academic Surgery, November 7–9, 2002, Boston, MA. 2Supported in part by NIGMS grants P50 GM38529-01, KO8 GM000675, and T32 GM08792. Journal Of Surgical Research 2003, 115: 121-126. PMID: 14572782, DOI: 10.1016/s0022-4804(03)00298-1.Peer-Reviewed Original ResearchConceptsTransvascular protein clearancePMN superoxide productionGut lymphIntraischemic hypothermiaNF-kappaB DNAProtein clearancePMN primingFistula modelRegional hypothermiaMesenteric ischemia/reperfusionSuperoxide productionPolymorphonuclear neutrophil (PMN) primingRemote organ injuryPro-inflammatory mediatorsMin of reperfusionEnd of ischemiaIschemia/reperfusionNF-kappaB activationNF-kappaB activityMesenteric ischemiaNeutrophil primingH reperfusionOrgan injuryReperfusion injuryMin reperfusion