2007
Radical scavenging for renal protection in cardiac surgery
Fischer U, Mehlhorn U. Radical scavenging for renal protection in cardiac surgery. Clinical Research In Cardiology Supplements 2007, 2: s81-s84. DOI: 10.1007/s11789-006-0042-9.Peer-Reviewed Original ResearchExtracorporeal Circulation activates endothelial Nitric Oxide Synthase (eNOS) in Erythrocytes
Fischer U, Schindler R, Brixius K, Mehlhorn U, Bloch W. Extracorporeal Circulation activates endothelial Nitric Oxide Synthase (eNOS) in Erythrocytes. The FASEB Journal 2007, 21: a1230-a1230. DOI: 10.1096/fasebj.21.6.a1230.Peer-Reviewed Original ResearchRed blood cellsCardiopulmonary bypassExtracorporeal circulationNitric oxide generationRBC-eNOSTime-dependent fashionSevere hypotensionCardiac surgeryPathophysiological hypothesesBlood samplesENOS activationHuman red blood cellsOxide generationBlood cellsENOSBypassDegree of activationHypotensionDependent fashionImportant predictorActivationMorbidityVasodilationHemodialysisPatients
2005
Risk stratification models fail to predict hospital costs of cardiac surgery patients
Hekmat K, Raabe A, Kroener A, Fischer U, Suedkamp M, Geissler H, Schwinger R, Kampe S, Mehlhorn U. Risk stratification models fail to predict hospital costs of cardiac surgery patients. Clinical Research In Cardiology 2005, 94: 748-753. PMID: 16258777, DOI: 10.1007/s00392-005-0300-8.Peer-Reviewed Original ResearchConceptsRisk stratification modelLength of stayTotal hospital costsCardiac surgical patientsHospital costsStratification modelSurgical patientsICU LOSCardiac surgery patientsConsecutive adult patientsPreoperative diagnostic testsICU staySurgery patientsAdult patientsCardiac surgeryRisk stratificationSpearman correlation coefficientProspective studyMean ageResultsA totalMethodsBetween OctoberMortality ratePatientsLinear regression analysisRoom costs
2004
Myocardial apoptosis prevention by radical scavenging in patients undergoing cardiac surgery
Fischer U, Tossios P, Huebner A, Geissler H, Bloch W, Mehlhorn U. Myocardial apoptosis prevention by radical scavenging in patients undergoing cardiac surgery. Journal Of Thoracic And Cardiovascular Surgery 2004, 128: 103-108. PMID: 15224028, DOI: 10.1016/j.jtcvs.2003.11.034.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcysteineAgedApoptosisCardiopulmonary BypassCaspase 3Caspase 7CaspasesCoronary Artery BypassCoronary Artery DiseaseDouble-Blind MethodEnzyme ActivationFemaleFree Radical ScavengersHeart RateHumansMaleMiddle AgedMyocardiumMyocytes, CardiacTreatment OutcomeVascular ResistanceVentricular Function, LeftVentricular PressureConceptsVentricular biopsy samplesN-acetylcysteineCardioplegic arrestBiopsy samplesCoronary artery bypass graft patientsLeft ventricular cardiac myocytesCardiac surgery patientsBypass graft patientsDouble-blind fashionConfidence intervalsCaspase-3Apoptosis inductionVentricular cardiac myocytesOxygen-derived speciesGraft patientsGray unitsSurgery patientsCardiac surgeryCardiopulmonary bypassClinical outcomesActive caspase-3Myocardial ischemiaApoptosis signal cascadePatientsCardiac myocytesCardiac myocyte regulatory proteins: Potential new targets for myocardial preservation in cardiac surgery?
Fischer U, Klass O, Stock U, Tossios P, Geissler H, Fischer J, Bloch W, de Vivie E, Mehlhorn U. Cardiac myocyte regulatory proteins: Potential new targets for myocardial preservation in cardiac surgery? The Thoracic And Cardiovascular Surgeon 2004, 52 DOI: 10.1055/s-2004-816779.Peer-Reviewed Original Research