1995
Endothelins: polyfunctional cytokines.
McMillen MA, Sumpio BE. Endothelins: polyfunctional cytokines. Journal Of The American College Of Surgeons 1995, 180: 621-37. PMID: 7749544.Peer-Reviewed Original ResearchAdrenal GlandsAmino Acid SequenceCell Transformation, NeoplasticCytokinesDigestive SystemEndothelinsEndothelium, VascularHumansInsulinKidneyLiverLungMacrophagesMolecular Sequence DataMonocytesMuscle, Smooth, VascularMyocardiumNeutrophilsParathyroid GlandsPeripheral Vascular DiseasesPituitary Gland, AnteriorProtein BindingReceptors, EndothelinThyroid GlandEndothelial-leukocyte interactions in the neutrophil cascade
McMillen M, Sumpio B. Endothelial-leukocyte interactions in the neutrophil cascade. The American Journal Of Surgery 1995, 169: 186-187. PMID: 7817990, DOI: 10.1016/s0002-9610(99)80130-5.Peer-Reviewed Original ResearchEndothelin-1 increases intracellular calcium in human monocytes and causes production of interleukin-6
McMillen M, Huribal M, Cunningham M, Kumar R, Sumpio B. Endothelin-1 increases intracellular calcium in human monocytes and causes production of interleukin-6. Critical Care Medicine 1995, 23: 34-40.. PMID: 8001384, DOI: 10.1097/00003246-199501000-00009.Peer-Reviewed Original ResearchConceptsEndothelin-1Intracellular calciumHuman monocytesIL-6Production of interleukinIL-6 productionIL-1 productionIntracellular calcium concentrationBasic science laboratoryM endothelinInterleukin-6Healthy donorsFura-2Control monocytesIschemic endotheliumMonocytesEndothelinCalcium concentrationMean valueCalciumTissue cultureInterleukinPhytohemagglutininEndotheliumEndotoxin
1994
ENDOTHELIN-STIMULATED MONOCYTE SUPERNATANTS ENHANCE NEUTROPHIL SUPEROXIDE PRODUCTION
Huribal M, Kumar R, Cunningham M, Sumpio B, McMillen M. ENDOTHELIN-STIMULATED MONOCYTE SUPERNATANTS ENHANCE NEUTROPHIL SUPEROXIDE PRODUCTION. Shock 1994, 1: 184-187. PMID: 7735949, DOI: 10.1097/00024382-199403000-00005.Peer-Reviewed Original ResearchConceptsEndothelin-1Neutrophil superoxide productionIL-8Monocyte supernatantsSuperoxide productionInterleukin-8 contentHuman peripheral blood monocytesPotent neutrophil activatorVascular smooth musclePeripheral blood monocytesIncubation of neutrophilsInterleukin-6M ETNeutrophil activatorProstaglandin E2Smooth muscleVasoconstrictive peptideBlood monocytesMonocytesBasal levelsNeutrophilsSupernatantH incubationDirect effectEndothelin