2005
MAPKs (ERK½, p38) and AKT Can Be Phosphorylated by Shear Stress Independently of Platelet Endothelial Cell Adhesion Molecule-1 (CD31) in Vascular Endothelial Cells*
Sumpio BE, Yun S, Cordova AC, Haga M, Zhang J, Koh Y, Madri JA. MAPKs (ERK½, p38) and AKT Can Be Phosphorylated by Shear Stress Independently of Platelet Endothelial Cell Adhesion Molecule-1 (CD31) in Vascular Endothelial Cells*. Journal Of Biological Chemistry 2005, 280: 11185-11191. PMID: 15668248, DOI: 10.1074/jbc.m414631200.Peer-Reviewed Original ResearchAnimalsCattleCell CommunicationEndothelial CellsEnzyme ActivationHumansMechanoreceptorsMiceMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3P38 Mitogen-Activated Protein KinasesPhosphorylationPlatelet Endothelial Cell Adhesion Molecule-1Protein Serine-Threonine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-aktStress, MechanicalTyrosine
2000
Endothelial cell response to different mechanical forces
Azuma N, Duzgun S, Ikeda M, Kito H, Akasaka N, Sasajima T, Sumpio B. Endothelial cell response to different mechanical forces. Journal Of Vascular Surgery 2000, 32: 789-794. PMID: 11013043, DOI: 10.1067/mva.2000.107989.Peer-Reviewed Original ResearchAnimalsAortaCattleCells, CulturedEndothelium, VascularEnzyme ActivationFocal Adhesion Kinase 1Focal Adhesion Protein-Tyrosine KinasesFocal AdhesionsHumansImmunoblottingJNK Mitogen-Activated Protein KinasesMechanoreceptorsMitogen-Activated Protein KinasesPhosphorylationProtein-Tyrosine KinasesSignal TransductionStress, Mechanical
1997
Gene Regulation by Mechanical Forces
Oluwole BO, Du W, Mills I, Sumpio BE. Gene Regulation by Mechanical Forces. Endothelium 1997, 5: 85-93. PMID: 9237042, DOI: 10.3109/10623329709079866.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCattleCell Adhesion MoleculesCell Culture TechniquesCells, CulturedEndothelinsEndothelium, VascularEpoprostenolFocal Adhesion Kinase 1Focal Adhesion Protein-Tyrosine KinasesGene Expression RegulationHemorheologyHumansMechanoreceptorsMembranes, ArtificialNitric OxideProtein-Tyrosine KinasesSignal TransductionStress, MechanicalTissue Plasminogen ActivatorTranscription FactorsTranscription, GeneticVacuumConceptsEndothelial cellsEndothelial cell functionCyclic strainVasoactive mediatorsSecond messenger cascadesNitric oxideBlood vesselsMechanical forcesCell functionMechanical deformationFlow of bloodMessenger cascadesLuminal surfaceSpecific response elementsPromoter geneResponse elementExternal forcesMediatorsCytoskeletal changesCellsForceProstacyclinExpressionTranscription levels
1993
Phospholipase C: A Putative Mechanotransducer for Endothelial Cell Response to Acute Hemodynamic Changes
Brophy CM, Mills I, Rosales O, Isales C, Sumpio BE. Phospholipase C: A Putative Mechanotransducer for Endothelial Cell Response to Acute Hemodynamic Changes. Biochemical And Biophysical Research Communications 1993, 190: 576-581. PMID: 8427600, DOI: 10.1006/bbrc.1993.1087.Peer-Reviewed Original ResearchConceptsEndothelial cellsAcute hemodynamic changesPhospholipase C activationHemodynamic changesProduction of inositolAcute decreaseAcute increaseIP3 generationEndothelial cell responsesCell responsesIP3 productionPutative mechanotransducersTransient increaseSpecific signal transduction pathwaysOngoing studiesCardiac cycleC activationSignal transduction pathwaysTransduction pathways
1990
Mechanosensitive adenylate cyclase activity in coronary vascular smooth muscle cells
Mills I, Letsou G, Rabban J, Sumpio B, Gewirtz H. Mechanosensitive adenylate cyclase activity in coronary vascular smooth muscle cells. Biochemical And Biophysical Research Communications 1990, 171: 143-147. PMID: 2393388, DOI: 10.1016/0006-291x(90)91368-3.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsSmooth muscle cellsCoronary vascular smooth muscle cellsMuscle cellsCyclase activityPorcine coronary artery smooth muscle cellsCultured vascular smooth muscle cellsArtery smooth muscle cellsCoronary artery smooth muscle cellsVascular smooth muscleMagnitude of stretchStretch-induced reductionAdenylate cyclase activityPotential biochemical mechanismsPerfusion pressureCoronary circulationCycles/minMyogenic responseSmooth muscleMechanical stretchAdenylate cyclasePotential mechanismsEntire time courseUnstretched cellsTime course