1988
Cyclosporine toxicity in the isolated perfused rat kidney.
Sumpio BE. Cyclosporine toxicity in the isolated perfused rat kidney. Transplantation Proceedings 1988, 20: 712-6. PMID: 3388509.Peer-Reviewed Original Research
1987
Mitochondrial Respiratory and Calcium Studies
SUMPIO B, BAUE A, CHAUDRY I. Mitochondrial Respiratory and Calcium Studies. Annals Of Surgery 1987, 206: 655-660. PMID: 3499878, PMCID: PMC1493310, DOI: 10.1097/00000658-198711000-00017.Peer-Reviewed Original ResearchConceptsRespiratory control ratioVerapamil pretreatmentTotal tissue Ca2Tissue ATP levelsCyA-induced nephrotoxicityCyA treatmentPharmacologic regimenRenal functionMitochondrial respiratory functionSimultaneous administrationCalcium studiesRespiratory functionKrebs bufferCortical mitochondriaMumol/Tissue Ca2Rat kidneyADP/O ratioCyANephrotoxicityATP levelsControl ratioVerapamilMitochondrial respiratoryCa2Comparison of effects of ATP-MgCl2 and adenosine-MgCl2 on renal function following ischemia
Sumpio BE, Hull MJ, Baue AE, Chaudry IH. Comparison of effects of ATP-MgCl2 and adenosine-MgCl2 on renal function following ischemia. American Journal Of Physiology 1987, 252: r388-r393. PMID: 3492930, DOI: 10.1152/ajpregu.1987.252.2.r388.Peer-Reviewed Original ResearchMeSH KeywordsAdenosineAdenosine TriphosphateAnimalsDiuresisGlomerular Filtration RateIschemiaKidneyMagnesiumMagnesium ChlorideMalePerfusionRatsRenal CirculationSodiumWaterConceptsRenal functionATP-MgCl2Warm ischemiaATP-MgCl2 treatmentKrebs-HCO3 bufferMM ATP-MgCl2Comparison of effectsNormothermic ischemiaTransient improvementIschemiaSalutary effectsControl valuesUrine samplesFunctional parametersKidneyMajor breakdown productAdenosineTreatmentBreakdown productsMmHgPerfusateMinAdministration
1986
Effects of ATP-MgCl2 and adenosine-MgCl2 administration on intracellular ATP levels in the kidney
Sumpio B, Hull M, Bauer A, Chaudry I. Effects of ATP-MgCl2 and adenosine-MgCl2 administration on intracellular ATP levels in the kidney. Biochimica Et Biophysica Acta 1986, 862: 303-308. PMID: 3778894, DOI: 10.1016/0005-2736(86)90232-4.Peer-Reviewed Original ResearchConceptsATP-MgCl2 administrationColloid oncotic pressureIntracellular ATPATP-MgCl2Exogenous administrationIntracellular ATP levelsRat kidneyOncotic pressureAdministrationTotal intracellular ATPPerfusate solutionKidneyIntracellular accumulationATP levelsAdenine nucleotidesSignificant accumulationATPPerfusate
1985
Reduction of the drug-induced nephrotoxicity by ATP-MgCl2. 1. Effects on the cis-Diamminedichloroplatinum-treated isolated perfused kidneys
Sumpio B, Chaudry I, Baue A. Reduction of the drug-induced nephrotoxicity by ATP-MgCl2. 1. Effects on the cis-Diamminedichloroplatinum-treated isolated perfused kidneys. Journal Of Surgical Research 1985, 38: 429-437. PMID: 3872963, DOI: 10.1016/0022-4804(85)90058-7.Peer-Reviewed Original ResearchConceptsAcute renal failureATP-MgCl2Hr of perfusionCis-DiamminedichloroplatinumNephrotoxic effectsReabsorptive capacityCDDP treatmentRat kidneyATP-MgCl2 treatmentIsolated rat kidneyDrug-induced nephrotoxicityDirect nephrotoxic effectNew therapeutic modalitiesProximal tubule cellsCancer chemotherapeutic agentsCDDP therapyRenal failureMarked diuresisProtein reabsorptionTherapeutic modalitiesTubule cellsChemotherapeutic agentsMicrograms/KidneyMarked inhibitionReduction of the drug-induced nephrotoxicity by ATP-MgCl2. II. Effects on gentamicin-treated isolated perfused kidneys
Sumpio B, Chaudry I, Baue A. Reduction of the drug-induced nephrotoxicity by ATP-MgCl2. II. Effects on gentamicin-treated isolated perfused kidneys. Journal Of Surgical Research 1985, 38: 438-445. PMID: 3872964, DOI: 10.1016/0022-4804(85)90059-9.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsGentamicinsGlomerular Filtration RateIn Vitro TechniquesKidneyMaleNephronsPerfusionRatsRats, Inbred StrainsConceptsDrug-induced nephrotoxicityGlomerular filtration rateRenal perfusate flowATP-MgCl2Filtration ratePerfusate flowMM ATP-MgCl2Prevention of nephrotoxicityGentamicin-induced nephrotoxicitySignificant clinical problemNon-pulsatile perfusionIsolated kidney preparationMin of perfusionHr of perfusionDose-dependent mannerTubular absorptionUrinary flowGentamicin treatmentProtein reabsorptionClinical problemNephrotoxicityPerfusate concentrationFractional clearanceClearance periodSodium absorptionAdenosine Triphosphate—Magnesium Chloride Ameliorates Reperfusion Injury Following Ischemia as Determined by Phosphorus Nuclear Magnetic Resonance
Sumpio B, Chaudry I, Baue A. Adenosine Triphosphate—Magnesium Chloride Ameliorates Reperfusion Injury Following Ischemia as Determined by Phosphorus Nuclear Magnetic Resonance. JAMA Surgery 1985, 120: 233-240. PMID: 3872113, DOI: 10.1001/archsurg.1985.01390260091013.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsIschemiaKidneyMagnetic Resonance SpectroscopyMalePerfusionPhosphorusRatsTime FactorsConceptsIntracellular acidosisPerfusate flowATP levelsAdenosine triphosphate-magnesium chlorideRenal ATP levelsMinutes of reperfusionTissue ATP levelsEffects of ischemiaAdenosine triphosphateML/minPostischemic administrationReperfusion injuryRenal ischemiaWarm ischemiaATP-MgCl2ReperfusionIschemiaInorganic phosphate peakIntracellular adenosine triphosphatePi peakRat kidneyAcidosisATP depletionMinutesMagnetic resonance
1984
Accelerated functional recovery of isolated rat kidney with ATP-MgCl2 after warm ischemia
Sumpio BE, Chaudry IH, Clemens MG, Baue AE. Accelerated functional recovery of isolated rat kidney with ATP-MgCl2 after warm ischemia. American Journal Of Physiology 1984, 247: r1047-r1053. PMID: 6334446, DOI: 10.1152/ajpregu.1984.247.6.r1047.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsIn Vitro TechniquesInulinIschemiaKidneyKidney Function TestsMalePerfusionRatsRats, Inbred StrainsTime FactorsConceptsRenal perfusate flow rateMM ATP-MgCl2Min of perfusionIsolated rat kidneyATP-MgCl2Renal functionWarm ischemiaWhole kidney inulin clearanceRat kidneyAccelerated functional recoveryMin of reperfusionMin of ischemiaUrine flow rateTissue ATP levelsFractional absorptionFunctional recoveryNormothermic ischemiaIschemia resultsMin ischemiaPerfusate flow rateInulin clearanceEarly recoverySystemic effectsIschemiaSodium values