Variceal Bleeding, Hypersplenism, and Systemic Mastocytosis: Pathophysiology and Management
Sumpio BE, O'Leary G, Gusberg RJ. Variceal Bleeding, Hypersplenism, and Systemic Mastocytosis: Pathophysiology and Management. JAMA Surgery 1988, 123: 767-769. PMID: 3130825, DOI: 10.1001/archsurg.1988.01400300113020.Peer-Reviewed Original ResearchConceptsSystemic mastocytosisType of shuntTissue mast cellsPortal pressure measurementsIntrahepatic fibrosisSatisfactory blockadePortal hypertensionVariceal bleedingPortal pressureShunt surgerySplenic bloodHistamine releaseSurgical diseaseHemodynamic issuesHistamine antagonistsMast cellsDisodium cromoglycateSystemic circulationSystemic effectsAbnormal proliferationMastocytosisUltrastructural studyPressure measurementsHypersplenismHypertension