2024
Patient-specific, multiscale modelling of neointimal hyperplasia in lower-limb vein grafts using readily available clinical data
Ninno F, Chiastra C, Donadoni F, Dardik A, Strosberg D, Aboian E, Tsui J, Balabani S, Díaz-Zuccarini V. Patient-specific, multiscale modelling of neointimal hyperplasia in lower-limb vein grafts using readily available clinical data. Journal Of Biomechanics 2024, 177: 112428. PMID: 39561605, DOI: 10.1016/j.jbiomech.2024.112428.Peer-Reviewed Original ResearchTime-averaged wall shear stressInflow boundary conditionsBoundary conditionsWall shear stressShear stressMultiscale modelWaveform shapePeripheral arterial diseaseNeointimal hyperplasiaVein graftsClinical dataMechanobiological mechanismsGraft responseMultiscale in silico modelSystolic acceleration timeClinician perspectives regarding CYP2C19 genotype testing in patients with critical limb ischemia: A Delphi approach.
Regan C, Scierka L, Dardik A, Tonnessen B, Iyad Ochoa Chaar C, Ionescu C, Aboian E, Cardella J, Nassiri N, Guzman R, Attaran R, Nagpal S, Shah S, Smolderen K, Mena-Hurtado C. Clinician perspectives regarding CYP2C19 genotype testing in patients with critical limb ischemia: A Delphi approach. Vascular 2024, 17085381241246318. PMID: 38669051, DOI: 10.1177/17085381241246318.Peer-Reviewed Original ResearchDual antiplatelet therapyPeripheral arterial diseaseCYP2C19 testingCYP2C19 mutationsHeterogeneity of treatment effectsPeripheral vascular interventionsConsensus statementKnowledge questionsAntiplatelet therapyGenetic testingVascular surgeryAcademic health systemBarriers to implementationInterquartile rangeCYP2C19 genotype testingVascular diseaseInterventional cardiologyModified Delphi methodPatient's metabolic statusManagement of patientsCritical limb ischemiaPerceived barriersPeripheral vascular diseaseArterial vascular diseaseClinician perspectivesLeveraging Artificial Intelligence to Optimize the Care of Peripheral Artery Disease Patients
Song J, Tomihama R, Roh D, Cabrera A, Dardik A, Kiang S. Leveraging Artificial Intelligence to Optimize the Care of Peripheral Artery Disease Patients. Annals Of Vascular Surgery 2024, 107: 48-54. PMID: 38582202, DOI: 10.1016/j.avsg.2023.11.057.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsReduced Muscle Mass and Muscle Quality in Patients with Intermittent Claudication due to Peripheral Artery Disease
Nishibe T, Dardik A, Akiyama S, Kano M, Fukuda S, Koizumi J, Nishibe M. Reduced Muscle Mass and Muscle Quality in Patients with Intermittent Claudication due to Peripheral Artery Disease. Annals Of Vascular Surgery 2024, 105: 275-281. PMID: 38570014, DOI: 10.1016/j.avsg.2023.12.094.Peer-Reviewed Original ResearchSkeletal muscle massPeripheral arterial diseaseBioelectrical impedance analysisAnkle-brachial indexAnkle-brachial pressure indexLeg skeletal muscle massLeg ischemiaMuscle massIntermittent claudicationLeg muscle massMuscle qualityArtery diseaseAssociated with reduced muscle massTokyo Medical University HospitalAssociated with skeletal muscle myopathyReduced muscle massMedical University HospitalLeg muscle qualitySkeletal muscle myopathyUniversity HospitalMuscle myopathyPatientsIschemiaClaudicationLower extremitiesRepresentation of female vascular surgeons in national clinical trial leadership: analysis of trends over 20 years
Kostiuk V, Thaxton C, Loh S, Cardella J, Dardik A, Tonnessen B. Representation of female vascular surgeons in national clinical trial leadership: analysis of trends over 20 years. JVS-Vascular Insights 2024, 2: 100077. DOI: 10.1016/j.jvsvi.2024.100077.Peer-Reviewed Original ResearchClinical trialsFemale vascular surgeonsVascular surgeonsMethods Clinical trialsArtery diseaseClinical trial leadershipSite principal investigatorsVascular conditionsAbdominal aortic aneurysmSurgeon-investigatorInvestigator-led trialsCarotid artery diseasePeripheral arterial diseaseCarotid diseaseProportion of womenVenous thrombectomyBoard certificationAortic aneurysmPercentage of womenIndustry-sponsored trialsTrial leadershipHemodialysis accessSubgroup analysisVascular surgerySurgeons
2023
Anatomic patterns in claudicants who fail supervised exercise therapy
Breen T, McGinigle K, Strosberg D, Dardik A, Altin S. Anatomic patterns in claudicants who fail supervised exercise therapy. Journal Of Vascular Surgery 2023, 79: 679-684.e1. PMID: 37984757, DOI: 10.1016/j.jvs.2023.11.020.Peer-Reviewed Original ResearchCritical limb-threatening ischemiaSupervised exercise therapyPeripheral arterial diseaseIntermittent claudicationCFA diseaseExercise therapyArterial diseaseAnatomic patternsCommon femoral artery diseaseFemoral artery diseaseAnkle-brachial indexLimb-threatening ischemiaSubset of patientsVeterans Health AdministrationPersistent symptomsProgressive diseaseProgressive symptomsArtery diseaseDisease locationPatientsWest HavenHealth AdministrationMultivariate analysisRevascularizationDiseaseModalities to Deliver Cell Therapy for Treatment of Chronic Limb Threatening Ischemia
Setia O, Lee S, Dardik A. Modalities to Deliver Cell Therapy for Treatment of Chronic Limb Threatening Ischemia. Advances In Wound Care 2023, 13: 253-279. PMID: 37002893, PMCID: PMC11305013, DOI: 10.1089/wound.2022.0114.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsChronic limb threatening ischemiaPeripheral arterial diseaseSevere peripheral arterial diseaseLimb threatening ischemiaClinical trialsCell therapyStem cell therapyIschemic limbsFeasible therapeutic alternativePromising treatment optionPre-clinical studiesCell deliveryPAD patientsArterial diseaseClinical benefitTreatment optionsSurgical methodsTherapeutic alternativeBest modalityHigh riskLimb lossSevere formTherapeutic benefitPatientsTherapyCarbon dioxide angiography during peripheral vascular interventions is associated with decreased cardiac and renal complications in patients with chronic kidney disease
Lee S, Ali S, Cardella J, Turner J, Guzman R, Dardik A, Ochoa Chaar C. Carbon dioxide angiography during peripheral vascular interventions is associated with decreased cardiac and renal complications in patients with chronic kidney disease. Journal Of Vascular Surgery 2023, 78: 201-208. PMID: 36948278, DOI: 10.1016/j.jvs.2023.03.029.Peer-Reviewed Original ResearchConceptsAdvanced chronic kidney diseaseChronic kidney diseasePeripheral vascular interventionsContrast volume usagePC-AKICarbon dioxide angiographyCardiac complicationsPropensity matchingKidney diseaseVascular interventionsPost-contrast acute kidney injuryAcute kidney injuryOutcomes of patientsPeripheral arterial diseasePoor renal functionMultivariate logistic regressionLower contrast volumeVolume of contrastCardiac comorbiditiesKidney injuryMinor amputationRenal complicationsRenal functionEndovascular therapyArterial disease
2018
Increased mortality in octogenarians treated for lifestyle limiting claudication
Erben Y, Mena‐Hurtado C, Miller S, Jean R, Sumpio BJ, Velasquez CA, Mojibian H, Aruny J, Dardik A, Sumpio B. Increased mortality in octogenarians treated for lifestyle limiting claudication. Catheterization And Cardiovascular Interventions 2018, 91: 1331-1338. PMID: 29405592, DOI: 10.1002/ccd.27523.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overComorbidityDatabases, FactualEndovascular ProceduresFemaleHealth StatusHumansIntermittent ClaudicationLength of StayMaleMiddle AgedPeripheral Arterial DiseaseRetrospective StudiesRisk FactorsTime FactorsTreatment OutcomeUnited StatesVascular Surgical ProceduresConceptsCharlson Comorbidity IndexOpen surgeryTreatment modalitiesHigher Charlson comorbidity indexMean Charlson Comorbidity IndexYounger cohortsInfectious wound complicationsInfra-inguinal interventionsAcute kidney injuryPeripheral arterial diseasePeripheral artery diseaseCongestive heart failureNationwide Inpatient SampleBinary logistic regression analysisLogistic regression analysisSkilled nursing facilitiesTreatment of LLCHospital mortalityComorbidity indexExercise therapyHospital stayKidney injuryOverall morbidityWound complicationsLonger LOS
2011
Surgical Treatment of Vascular Occlusive Disease
Feigel A, Dardik A. Surgical Treatment of Vascular Occlusive Disease. 2011, 663-672. DOI: 10.1007/978-1-4419-6999-6_54.ChaptersPeripheral arterial diseaseBlood flowElderly patientsIntimal thickeningLower extremitiesElderly populationImpact of PADSymptoms of PADTreatment of PADVascular occlusive diseaseProgressive intimal thickeningDistal blood flowSpectrum of diseaseArterial blood flowAtherosclerotic intimal thickeningDistal emboliOcclusive diseaseCoronary diseaseSurgical treatmentArterial diseaseCarotid diseaseEndovascular treatmentVisceral circulationAbdominal visceraLuminal diameter