2024
Disturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation, and neointimal hyperplasia
Bai H, Varsanik M, Thaxton C, Ohashi Y, Gonzalez L, Zhang W, Aoyagi Y, Kano M, Yatsula B, Li Z, Pocivavsek L, Dardik A. Disturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation, and neointimal hyperplasia. AJP Heart And Circulatory Physiology 2024, 326: h1446-h1461. PMID: 38578237, DOI: 10.1152/ajpheart.00054.2024.Peer-Reviewed Original ResearchConceptsEndothelial cell lossOutflow veinChronic kidney diseaseJuxta-anastomotic areaMouse AVF modelNeointimal hyperplasiaThrombus formationAcute thrombus formationCell lossHuman AVF maturationGene OntologyAVF maturationAVF patencyEarly thrombus formationArteriovenous fistulaC57BL/6 miceClinical failureWistar ratsEndothelial lossKidney diseaseImmune responseEndothelial cellsHyperplasiaMiceAVF
2022
A three-layered hydrogel patch with hierarchy releasing of PLGA nanoparticle drugs decrease neointimal hyperplasia
Wei S, Li J, He H, Shu C, Dardik A, Bai H. A three-layered hydrogel patch with hierarchy releasing of PLGA nanoparticle drugs decrease neointimal hyperplasia. Smart Materials In Medicine 2022, 3: 139-147. DOI: 10.1016/j.smaim.2021.12.005.Peer-Reviewed Original Research
2020
Artery to vein configuration of arteriovenous fistula improves hemodynamics to increase maturation and patency
Bai H, Sadaghianloo N, Gorecka J, Liu S, Ono S, Ramachandra AB, Bonnet S, Mazure NM, Declemy S, Humphrey JD, Dardik A. Artery to vein configuration of arteriovenous fistula improves hemodynamics to increase maturation and patency. Science Translational Medicine 2020, 12 PMID: 32817365, PMCID: PMC7705473, DOI: 10.1126/scitranslmed.aax7613.Peer-Reviewed Original ResearchConceptsArteriovenous fistulaHemodialysis accessNeointimal hyperplasiaEndothelial nitric oxide synthaseDurable surgical optionUremic male ratsRadial-cephalic arteriovenous fistulaKruppel-like factor 2Nitric oxide synthasePeak systolic velocityLong-term patencyReintervention rateSecondary patencyImproved hemodynamicsFemale patientsReimplantation techniqueSurgical optionsSystolic velocityMale ratsOxide synthaseFistula modelPatencyHemodynamicsDifferent hemodynamicsFemale animals
2012
Neointimal Hyperplasia: Basic Considerations
Model L, Dardik A. Neointimal Hyperplasia: Basic Considerations. 2012, 178-196. DOI: 10.1002/9781118481370.ch10.ChaptersSmooth muscle cell proliferationMuscle cell proliferationNeointimal hyperplasiaIII trialsBypass graft failureCell proliferationVein graft adaptationVein graft restenosisExtracellular matrix depositionGraft failureVein graftsVascular surgeonsVascular surgeryGraft restenosisGraft adaptationNew molecular mechanismHyperplasiaTrialsRestenosisMatrix depositionBody responseArterial environmentMolecular mechanismsDisappointing failuresProliferation
2003
Shear stress stimulated endothelial cell derived PDGF and IL-1 alpha both stimulate SMC chemotaxis via the MAPK pathway
Dardik A, Yamashita A, Aziz F, Paszkowiak J, Asada H, Sumpio B. Shear stress stimulated endothelial cell derived PDGF and IL-1 alpha both stimulate SMC chemotaxis via the MAPK pathway. Journal Of Surgical Research 2003, 114: 249. DOI: 10.1016/j.jss.2003.08.159.Peer-Reviewed Original ResearchPlatelet-derived growth factor-BBIL-1SMC migrationEndothelial cellsMAPK inhibitor PD98059Pathogenesis of atherosclerosisSMC chemotaxisSmooth muscle cell migrationIL-1 alphaInterleukin-1 alphaSimilar degreeInhibitor PD98059Muscle cell migrationMAPK pathwayHemodynamic forcesGrowth factor-BBAortic endothelial cellsSS stimulationBovine aortic endothelial cellsArterial levelsNeointimal hyperplasiaParacrine mechanismsSMC mitogenBoyden chamberSoluble factors