2020
Neurologic Characterization of Craniosynostosis: Can Direct Brain Recordings Predict Language Development?
Wu R, Nie J, Abraham P, Halligan T, Gabrick K, Peck CJ, Sawh-Martinez R, Steinbacher DM, Alperovich M, McPartland J, Persing JA. Neurologic Characterization of Craniosynostosis: Can Direct Brain Recordings Predict Language Development? Journal Of Craniofacial Surgery 2020, 32: 78-82. PMID: 32941205, DOI: 10.1097/scs.0000000000007004.Peer-Reviewed Original ResearchConceptsNeural responsesLanguage deficitsLanguage developmentERP assessmentMetopic patientsMismatch negativity waveLarger negative amplitudesLong-term cognitionLanguage achievementCognitive outcomesMMNBrain recordingsInfant developmentBayley ScalesNegative amplitudeBSID scoresEEG testingBSIDDeficitsElectroencephalogramNeurocognitionCognitionSpeechStimuliYears of ageRisk of peri-operative complications in children receiving preoperative steroids
Mets EJ, Chouairi F, Mirza H, Allam O, Park KE, Junn A, Alperovich M. Risk of peri-operative complications in children receiving preoperative steroids. Pediatric Surgery International 2020, 36: 1345-1352. PMID: 32918623, DOI: 10.1007/s00383-020-04742-9.Peer-Reviewed Original ResearchConceptsAdverse eventsPediatric patientsSteroid usePreoperative steroidsNational Surgical Quality Improvement Project Pediatric databaseThirty-day adverse eventsPropensity scorePostoperative adverse eventsPeri-operative complicationsPediatric surgery patientsSimilar larger studiesMore comorbiditiesPerioperative impactHospital stayPerioperative complicationsAdult patientsPatient demographicsSteroid treatmentSurgery patientsSurgical variablesWound dehiscenceSurgical outcomesPediatric databasePatientsLarger studyWhat Is the Difference in Cranial Base Morphology in Isolated and Syndromic Bicoronal Synostosis?
Lu X, Forte AJ, Wilson AT, Park KE, Allam O, Mozaffari MA, Alperovich M, Steinbacher DM, Alonso N, Persing JA. What Is the Difference in Cranial Base Morphology in Isolated and Syndromic Bicoronal Synostosis? Plastic & Reconstructive Surgery 2020, 146: 599-610. PMID: 32842109, DOI: 10.1097/prs.0000000000007068.Peer-Reviewed Original ResearchComparison of Neurocognitive Outcomes in Postoperative Adolescents with Unilateral Coronal Synostosis.
Wu RT, Gabrick KS, Singh A, Landi N, Taylor JA, Bartlett SP, Persing JA, Alperovich M. Comparison of Neurocognitive Outcomes in Postoperative Adolescents with Unilateral Coronal Synostosis. Plastic & Reconstructive Surgery 2020, 146: 614-619. PMID: 32842112, DOI: 10.1097/prs.0000000000007067.Peer-Reviewed Original ResearchConceptsPerformance intelligence quotientVisual-motor integrationVerbal intelligence quotientIntelligence quotientMean full-scale intelligence quotientMotor integrationLeft-sided patientsRight-side patientsNonsyndromic craniosynostosisLong-term functionLarge population studiesCranial vaultHigh motor coordinationMotor achievementsUnilateral coronal synostosisFull-scale intelligence quotientIndependent predictorsFemale patientsStudy cohortNeurodevelopmental assessmentAverage intelligence quotient scoresMean ageControl subjectsNeurocognitive outcomesIntelligence quotient scoresAssessing Facial Asymmetry in Postoperative Patients With Unilateral Coronal Craniosynostosis.
Gabrick KS, Wu RT, Singh A, Bartlett SP, Taylor JA, Persing JA, Alperovich M. Assessing Facial Asymmetry in Postoperative Patients With Unilateral Coronal Craniosynostosis. Journal Of Craniofacial Surgery 2020, 31: 1000-1005. PMID: 32176017, DOI: 10.1097/scs.0000000000006355.Peer-Reviewed Original ResearchConceptsUnilateral craniosynostosisPatient-reported outcomesFacial asymmetrySurgical correctionPatient-reported outcome scoresPercent of patientsOrbital dystopiaSchool-aged patientsDysmorphic facial featuresUnilateral coronal craniosynostosisChin point deviationPostoperative patientsOutcome scoresChildren's HospitalPreoperative deformityPearson correlationPatientsAverage ageCranial base angulationRoot angulationOverall facial asymmetryNasal rootAngulationCoronal craniosynostosisHospitalClassification of Subtypes of Crouzon Syndrome Based on the Type of Vault Suture Synostosis.
Lu X, Sawh-Martinez R, Forte AJ, Wu R, Cabrejo R, Wilson A, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Classification of Subtypes of Crouzon Syndrome Based on the Type of Vault Suture Synostosis. Journal Of Craniofacial Surgery 2020, 31: 678-684. PMID: 32068731, DOI: 10.1097/scs.0000000000006173.Peer-Reviewed Original ResearchConceptsClass IIICrouzon syndromeClass IClass IISuture involvementSuture synostosisSimilar craniofacial characteristicsComputed tomography scanClassification of subtypesSurgical interventionMorphology of patientsAnatomic deformityTomography scanSurgical techniqueCT scanDifferent subtypesSagittal synostosisSyndromeClass IVPremature closureCraniofacial characteristicsSevere craniofacial malformationsCranial base lengthSynostosisDifferent pathologiesSMAD6 Genotype Predicts Neurodevelopment in Nonsyndromic Craniosynostosis.
Wu RT, Timberlake AT, Abraham PF, Gabrick KS, Lu X, Peck CJ, Sawh-Martinez RF, Steinbacher DM, Alperovich MA, Persing JA. SMAD6 Genotype Predicts Neurodevelopment in Nonsyndromic Craniosynostosis. Plastic & Reconstructive Surgery 2020, 145: 117e-125e. PMID: 31592950, DOI: 10.1097/prs.0000000000006319.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesChildChild BehaviorChild DevelopmentChild, PreschoolCraniosynostosesCraniotomyDevelopmental DisabilitiesDouble-Blind MethodFemaleFollow-Up StudiesHumansInfantIntelligence TestsLoss of Function MutationMalePlastic Surgery ProceduresProspective StudiesSkullSmad6 ProteinTreatment Outcome
2019
Secondary Cleft Rhinoplasty in 1720 Patients: Are National Practices Consistent With Guidelines?
Chouairi F, Torabi SJ, Gabrick KS, Persing JA, Alperovich M. Secondary Cleft Rhinoplasty in 1720 Patients: Are National Practices Consistent With Guidelines? The Cleft Palate-Craniofacial Journal 2019, 57: 438-443. PMID: 31594399, DOI: 10.1177/1055665619879830.Peer-Reviewed Original ResearchConceptsSecondary cleft rhinoplastyCleft rhinoplastyMean ageAdjunct procedureNational Surgical Quality Improvement Program Pediatric databaseSecondary cleft lip rhinoplastyTympanostomy tube placementCleft lip rhinoplastySeptal componentFisher's exact testCleft lip revisionCommon adjunct procedureImmature patientsPatient ageBilateral patientsFemale patientsTube placementRib graftingChi-square analysisInclusion criteriaSurgical proceduresLip revisionMAIN OUTCOMEPatientsAuricular graftAirway Analysis in Apert Syndrome.
Forte AJ, Lu X, Hashim PW, Steinbacher DM, Alperovich M, Persing JA, Alonso N. Airway Analysis in Apert Syndrome. Plastic & Reconstructive Surgery 2019, 144: 704-709. PMID: 31461034, DOI: 10.1097/prs.0000000000005937.Peer-Reviewed Original ResearchConceptsPosterior nasal spineApert syndromeNasal spineTomographic scanPharyngeal airway volumeRespiratory insufficiencyAirway compromiseAirway volumeAirway spaceRespiratory impairmentClinical managementAirway analysisPosterior airwayNasal cavityDisease comorbiditiesPatientsSyndromeSkull baseNasal measurementsSpine distanceStatistical significanceMidfacial deformitiesSpineAirwayPharyngeal regionWhat Is the Skull Structure Influence of Squamosal Suture Synostosis in Nonsyndromic and Syndromic Crouzon Craniosynostosis?
Lu X, Chen G, Forte AJ, Cabrejo R, Singh A, Kyle G, Steinbacher DM, Alperovich M, Alonso N, Persing JA. What Is the Skull Structure Influence of Squamosal Suture Synostosis in Nonsyndromic and Syndromic Crouzon Craniosynostosis? Journal Of Craniofacial Surgery 2019, 30: 1671-1675. PMID: 30950948, DOI: 10.1097/scs.0000000000005396.Peer-Reviewed Original ResearchConceptsMiddle cranial fossaAnterior cranial fossaCranial fossaPosterior cranial fossaSquamosal synostosisFossa volumeCrouzon syndromeSquamosal suture synostosisComputed tomography scanCranial volumeNonsyndromic craniosynostosis patientsVolume reductionSevere volume reductionTomography scanNormal controlsMorphologic effectsCraniosynostosis patientsFossaPremature closureSyndromic conditionsSuture synostosisSyndromic synostosisFrankfort horizontal planeSynostosisThree-dimensional cephalometryAnalysis of Airway and Midface in Crouzon Syndromes
Forte AJ, Lu X, Hashim PW, Steinbacher DM, Alperovich M, Persing JA, Alonso N. Analysis of Airway and Midface in Crouzon Syndromes. Annals Of Plastic Surgery 2019, Publish Ahead of Print: &na;. PMID: 30633021, DOI: 10.1097/sap.0000000000001740.Peer-Reviewed Original ResearchConceptsPharyngeal airway volumeComputed tomography scanAirway volumeControl subjectsTomography scanCrouzon syndromeAge-matched control subjectsAnalysis of airwaysSevere respiratory impairmentNasal airway volumePosterior pharyngeal wallEarly mixed dentitionCrouzon groupSurgical interventionRespiratory impairmentUpper airwaySoft tissue measurementsPharyngeal wallPosterior tongueMixed dentitionAirwayPatientsSyndromeVolumetric assessmentT-testAssociation of Regional Cranial Base Deformity and Ultimate Structure in Crouzon Syndrome.
Lu X, Jorge Forte A, Sawh-Martinez R, Wu R, Cabrejo R, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Association of Regional Cranial Base Deformity and Ultimate Structure in Crouzon Syndrome. Plastic & Reconstructive Surgery 2019, 143: 1233e-1243e. PMID: 31136487, DOI: 10.1097/prs.0000000000005643.Peer-Reviewed Original ResearchMandibular Spatial Reorientation and Morphological Alteration of Crouzon and Apert Syndrome.
Lu X, Sawh-Martinez R, Forte AJ, Wu R, Cabrejo R, Wilson A, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Mandibular Spatial Reorientation and Morphological Alteration of Crouzon and Apert Syndrome. Annals Of Plastic Surgery 2019, 83: 568-582. PMID: 31008788, DOI: 10.1097/sap.0000000000001811.Peer-Reviewed Original ResearchUnderstanding the Learning Disabilities Linked to Sagittal Craniosynostosis
Cabrejo R, Lacadie C, Brooks E, Beckett J, Sun A, Yang J, Chuang C, Eilbott J, Duncan C, Steinbacher D, Alperovich M, Ventola P, Pelphrey K, Constable T, Persing J. Understanding the Learning Disabilities Linked to Sagittal Craniosynostosis. Journal Of Craniofacial Surgery 2019, 30: 497-502. PMID: 30676447, DOI: 10.1097/scs.0000000000005194.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderFunctional magnetic resonance imagingSagittal nonsyndromic craniosynostosisSagittal craniosynostosisDifferent neural connectionsPrimary visual cortexVisual association cortexMagnetic resonance imagingStatistical parametric mappingDeficit hyperactivity disorderBrodmann area 11Association cortexVisual cortexResonance imagingNeurocognitive deficitsNeural connectionsPatientsFMRI scansHyperactivity disorderNonsyndromic craniosynostosisParametric mappingControl adolescentsAuditory processingArea 11CraniosynostosisSpatial and temporal changes of midface in Apert’s syndrome
Lu X, Forte AJ, Sawh-Martinez R, Wu R, Cabrejo R, Wilson A, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Spatial and temporal changes of midface in Apert’s syndrome. Journal Of Plastic Surgery And Hand Surgery 2019, 53: 130-137. PMID: 30782083, DOI: 10.1080/2000656x.2018.1541324.Peer-Reviewed Original ResearchNational Patterns in Surgical Management of Syndactyly: A Review of 956 Cases
Chouairi F, Mercier MR, Persing JS, Gabrick KS, Clune J, Alperovich M. National Patterns in Surgical Management of Syndactyly: A Review of 956 Cases. Hand 2019, 15: 666-673. PMID: 30770023, PMCID: PMC7543215, DOI: 10.1177/1558944719828003.Peer-Reviewed Original ResearchConceptsOperative timeComplex syndactylySyndactyly repairNational Surgical Quality Improvement Program Pediatric databaseOrthopaedic surgeonsSimple syndactylySuperficial surgical site infectionPlastic surgeonsSurgical site infectionTime of surgeryLonger operative timeShorter operative timeMulti-institutional outcome analysisNumber of patientsPreoperative comorbiditiesReconstructive complicationsSyndactyly casesVentilator dependencePerioperative outcomesAirway abnormalitiesMost patientsPatient demographicsSurgical factorsSite infectionSurgical management
2018
Orbit, zygoma, and maxilla growth patterns in Crouzon syndrome
Lu X, Forte AJ, Sawh-Martinez R, Wu R, Cabrejo R, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Orbit, zygoma, and maxilla growth patterns in Crouzon syndrome. International Journal Of Oral And Maxillofacial Surgery 2018, 48: 309-321. PMID: 30389113, DOI: 10.1016/j.ijom.2018.10.013.Peer-Reviewed Original ResearchConceptsCrouzon syndromeCT scanAnteroposterior lengthWidth of maxillaPreoperative CT scanMonths-2 yearsMonths of agePrincipal deformityControl subjectsGlobe projectionAge subgroupsMaxillary wideningSecondary deformitiesOrbital wallAnterior protrusionSyndromeFacial malformationsMonthsDeformityAnteroposterior positionZygomatic regionCranial baseZygomaMalformationsMaterialise softwareAnterior convex lateral orbital wall: distinctive morphology in Apert syndrome
Lu X, Forte AJ, Sawh-Martinez R, Wu R, Cabrejo R, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Anterior convex lateral orbital wall: distinctive morphology in Apert syndrome. British Journal Of Oral And Maxillofacial Surgery 2018, 56: 864-869. PMID: 30337164, DOI: 10.1016/j.bjoms.2018.09.011.Peer-Reviewed Original ResearchNormal angulation of skull base in Apert syndrome
Lu X, Forte AJ, Sawh-Martinez R, Wu R, Cabrejo R, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Normal angulation of skull base in Apert syndrome. Journal Of Cranio-Maxillofacial Surgery 2018, 46: 2042-2051. PMID: 30391086, DOI: 10.1016/j.jcms.2018.09.026.Peer-Reviewed Original ResearchConceptsAnterior cranial baseApert syndromeCranial base lengthSkull baseSevere craniofacial deformitiesPosterior cranial base lengthYears of ageMonths of ageUnoperated patientsCT scanAnterior cranial base lengthCranial base angleLate infancySyndromeAge rangeCraniofacial deformitiesCranial baseDeformityAdditive effectSkull vaultMonthsAngulationSignificant changesAgeBase length
2016
Outpatient Alveolar Bone Grafting
Farber SJ, Runyan CM, Stern MJ, Massie JP, Alperovich M, Flores RL. Outpatient Alveolar Bone Grafting. Journal Of Craniofacial Surgery 2016, 27: 1661-1664. PMID: 27438449, DOI: 10.1097/scs.0000000000002899.Peer-Reviewed Original ResearchConceptsAlveolar bone graftTotal direct costsVariable direct costsInpatient stayObservation groupSite painDirect costsOutpatient costsRetrospective single-institution reviewDonor site painGroup of patientsSame-day dischargeSingle-institution reviewPostoperative inpatient stayOperating room costsCost-efficient treatmentHospital stayInpatient costsOutpatient groupTrephine techniqueAlveolar boneABG surgeryBone graftStayRoom costs