A new obesity-prone, glucose-intolerant rat strain (F.DIO)
Levin BE, Dunn-Meynell AA, McMinn JE, Alperovich M, Cunningham-Bussel A, Chua SC. A new obesity-prone, glucose-intolerant rat strain (F.DIO). AJP Regulatory Integrative And Comparative Physiology 2003, 285: r1184-r1191. PMID: 12855420, DOI: 10.1152/ajpregu.00267.2003.Peer-Reviewed Original ResearchConceptsDiet-induced obeseF344 ratsOral glucoseLeptin levelsInsulin responseHigher plasma leptin levelsExaggerated insulin responseLow-fat chowHigher leptin levelsPlasma leptin levelsGreater insulin responseOutbred Sprague-Dawley ratsSprague-Dawley ratsF344 damsDIO ratsFat dietMale ratsF344 malesHigh-energy dietRat strainsMale offspringRatsPolygenic fashionMalesPolygenic mode