2024
Long-term Posttransplant-Related Bone Volumetric Changes in Eight Face Transplant Recipients – a Single Center Retrospective Case Series
Huelsboemer L, Boroumand S, Boroumand T, Vafa A, Parikh N, Chiarella L, Knoedler L, Stögner V, Hung P, Sadigh S, Haykal S, Pomahac B, Kauke-Navarro M. Long-term Posttransplant-Related Bone Volumetric Changes in Eight Face Transplant Recipients – a Single Center Retrospective Case Series. Journal Of Plastic Reconstructive & Aesthetic Surgery 2024 DOI: 10.1016/j.bjps.2024.11.025.Peer-Reviewed Original ResearchFacial vascularized composite allograftBone volume changesBone volumeChronic rejection processRetrospective case seriesComputed tomography scanBone volume lossWilcoxon rank sum testNative boneSignificant median decreaseBone volume stabilityRank sum testFace transplant recipientsBone remodeling ratesVascularized composite allograftsChronic immunosuppressionTooth lossTransplant recipientsAllograft cohortCase seriesTomography scanVolume lossMedian decreaseMedical comorbiditiesHistopathological analysisTen Year Follow-up After Face Transplantation – a Single Center Retrospective Cohort Study
Huelsboemer L, Kauke-Navarro M, Boroumand S, Parikh N, Hosseini H, Yu C, Stögner V, Ko C, Perry B, Formica R, Hung P, Mahajan A, Azzi J, Murphy G, Pomahac B. Ten Year Follow-up After Face Transplantation – a Single Center Retrospective Cohort Study. American Journal Of Transplantation 2024 PMID: 39413877, DOI: 10.1016/j.ajt.2024.10.007.Peer-Reviewed Original ResearchChronic rejectionFace transplantationFollow-upSingle center retrospective cohort studyFunctional outcomesSensory returnAnalysis of functional outcomesMedian follow-upIncidence of malignancyMetabolic side effectsGraft rejection episodesComputed tomography angiogramRetrospective cohort studyEvidence of vasculopathyFollow-up periodLong-term outcomesYear follow-upFacial motor functionRejection episodesInfectious complicationsTransplant recipientsPatient ageGraft retentionMedical complicationsCohort studyImmunosuppressive strategies in face and hand transplantation: a comprehensive systematic review of current therapy regimens and outcomes
Huelsboemer L, Boroumand S, Kochen A, Dony A, Moscarelli J, Hauc S, Stögner V, Formica R, Pomahac B, Kauke-Navarro M. Immunosuppressive strategies in face and hand transplantation: a comprehensive systematic review of current therapy regimens and outcomes. Frontiers In Transplantation 2024, 3: 1366243. PMID: 38993787, PMCID: PMC11235358, DOI: 10.3389/frtra.2024.1366243.Peer-Reviewed Original ResearchCMV infectionImmunosuppressive regimensImmunosuppressive strategiesTransplant recipientsIncidence of rejection episodesClinical CMV infectionTriple maintenance therapyIncidence of rejectionEpisodes of rejectionIndividualized immunosuppressive regimensEffective immunosuppressive therapySystematic reviewFace transplant patientsHand transplant recipientsHand transplantationFacial graftImmunosuppressive therapyMaintenance therapyRejection episodesFacial mucosaGraft lossGraft rejectionTherapy regimensTransplant patientsRenal failure
2023
Update on long-term mental health outcomes in eight face transplant recipients from a single center
Huelsboemer L, Stögner V, Hosseini H, Hauc S, Boroumand S, Parikh N, Blood A, Mookerjee V, Kauke-Navarro M, Nizzi M, Pomahac B. Update on long-term mental health outcomes in eight face transplant recipients from a single center. The International Journal Of Psychiatry In Medicine 2023, 59: 583-594. PMID: 38152028, DOI: 10.1177/00912174231225764.Peer-Reviewed Original ResearchFace transplant recipientsSelf-reported qualityLong-term psychosocial outcomesMental healthMental health dynamicsLong-term mental healthOngoing psychological supportBetter mental healthBrief COPEPsychological dimensionsPsychological benefitsPsychosocial outcomesLong-term journeyPsychological supportInstrumental supportMixed-method approachDepression scoresFacial disfigurementHealth DynamicsFace transplantationTransplant recipientsOlder ageScoresSupportLast followAdvancing Face Transplantation: A Critical Analysis of Revisions and Long-Term Surgical Outcomes in 10 Cases
Mookerjee V, Kauke-Navarro M, Hauc S, Huelsboemer L, Formica R, Pomahac B. Advancing Face Transplantation: A Critical Analysis of Revisions and Long-Term Surgical Outcomes in 10 Cases. Plastic & Reconstructive Surgery 2023, 154: 577e-584e. PMID: 37699110, DOI: 10.1097/prs.0000000000011058.Peer-Reviewed Original ResearchMedical recordsLong-term surgical outcomesFace transplantationChronic allograft rejectionMedian time intervalLong-term outcomesComplex facial injuriesPatients' medical recordsFace transplantFace transplant recipientsAllograft rejectionTransplant recipientsSurgical revisionSurgical outcomesMajority of revisionsOperative reportsRevision surgeryProvider teamRetrospective analysisTEN casesFacial injuriesPeriorbital tissuesPatientsTransplantationMost interventionsTolerance Induction in Vascularized Composite Allotransplantation—A Brief Review of Preclinical Models
Huelsboemer L, Kauke-Navarro M, Reuter S, Stoegner V, Feldmann J, Hirsch T, Kueckelhaus M, Dermietzel A. Tolerance Induction in Vascularized Composite Allotransplantation—A Brief Review of Preclinical Models. Transplant International 2023, 36: 10955. PMID: 36846605, PMCID: PMC9946984, DOI: 10.3389/ti.2023.10955.Peer-Reviewed Original ResearchConceptsTolerance inductionLong-term effectsAnimal modelsImmune systemDonor-specific toleranceLong-term outcomesRecipient's immune systemPreclinical animal modelsNovel therapeutic strategiesPre-clinical studiesVascularized Composite AllotransplantationChronic rejectionImmunosuppressive protocolsTransplant recipientsAllograft rejectionOrgan dysfunctionPreclinical modelsComposite allograftsTherapeutic strategiesComposite allotransplantationClinical practiceIS protocolClinical translationInductionReview article
2021
Dynamic Maxillary Sinus Changes of Facial Vascularized Composite Allotransplants.
Kauke M, Safi AF, Palmer WJ, Kollar B, Nelms L, Tchiloemba B, Haug V, Pomahac B. Dynamic Maxillary Sinus Changes of Facial Vascularized Composite Allotransplants. Plastic & Reconstructive Surgery 2021, 147: 722-727. PMID: 33620943, DOI: 10.1097/prs.0000000000007673.Peer-Reviewed Original ResearchConceptsMaxillary sinusFace transplant recipientsTransplant recipientsAllograft rejectionTissue changesBiopsy-proven allograft rejectionDiagnosis of rejectionMedication side effectsMaxillary sinus mucosaIndividualized treatment strategiesTissue allograft rejectionVascularized composite allotransplantsFace transplant patientsDynamic tissue changesRadiologic biomarkersRejection gradeTransplant patientsMucosal swellingSinonasal tractSinus changesSinus mucosaClinical managementTomographic scanPathologic changesTreatment strategies
2019
MMP3 Is a Non-invasive Biomarker of Rejection in Skin-Bearing Vascularized Composite Allotransplantation: A Multicenter Validation Study
Kollar B, Uffing A, Borges TJ, Shubin AV, Aoyama BT, Dagot C, Haug V, Kauke M, Safi AF, Talbot SG, Morelon E, Dakpe S, Pomahac B, Riella LV. MMP3 Is a Non-invasive Biomarker of Rejection in Skin-Bearing Vascularized Composite Allotransplantation: A Multicenter Validation Study. Frontiers In Immunology 2019, 10: 2771. PMID: 31849957, PMCID: PMC6897344, DOI: 10.3389/fimmu.2019.02771.Peer-Reviewed Original ResearchConceptsMatrix metalloproteinase-3MMP3 levelsNon-invasive biomarkersTransplant recipientsAcute rejectionHealthy controlsComposite allotransplantationRejection stateCandidate non-invasive biomarkersUpper extremity transplant recipientsSerum samplesAntibody-mediated rejectionKidney transplant recipientsSeverity of rejectionPre-transplant levelsAutoimmune skin diseaseLongitudinal serum samplesSkin disease patientsVascularized Composite AllotransplantationMulticenter validation studyFace transplant recipientsLarger validation studiesClinical VCARejection episodesVCA patients