2007
Safety Evaluation of Topically Applied Amitriptyline in Porcine Full-Thickness Wounds
Pomahac B, Zuhaili B, Kudsi Y, Bleiziffer O, Velander P, Eriksson E, Gerner P. Safety Evaluation of Topically Applied Amitriptyline in Porcine Full-Thickness Wounds. Regional Anesthesia & Pain Medicine 2007, 32: 377-381. PMID: 17961834, DOI: 10.1016/j.rapm.2007.06.003.Peer-Reviewed Original ResearchConceptsFull-thickness woundsPorcine full-thickness woundsSerum levelsWound chambersTopical applicationWound contractionEffects of amitriptylineManagement of painDaily topical applicationHigher serum levelsExcised burn woundsFull-thickness skin biopsiesOvert toxic effectsLevels of amitriptylineTricyclic antidepressant amitriptylineNeuropathic painPain clinicHistopathological findingsNormal salineSkin biopsiesHistological assessmentAntidepressant amitriptylineDay 2Control groupAmitriptyline
1998
Dermatan Sulfate Released after Injury Is a Potent Promoter of Fibroblast Growth Factor-2 Function*
Penc S, Pomahac B, Winkler T, Dorschner R, Eriksson E, Herndon M, Gallo R. Dermatan Sulfate Released after Injury Is a Potent Promoter of Fibroblast Growth Factor-2 Function*. Journal Of Biological Chemistry 1998, 273: 28116-28121. PMID: 9774430, DOI: 10.1074/jbc.273.43.28116.Peer-Reviewed Original ResearchConceptsWound fluidDermatan sulfateFactor 2 activityFibroblast growth factor-2Growth factor 2Factor 2 functionHuman wound fluidPotent mediatorSulfated glycosaminoglycan concentrationsSyndecan-1Fibroblast growth factor‐2 activityWound repairWound healingCell proliferationFGF-2Glycosaminoglycan concentrationSoluble proteoglycanFactor 2Immunoblot analysisVivo sourceHeparan sulfatePotent promoterFirst evidenceSyndecan-4Proteoglycans