2023
Cellular activation pathways and interaction networks in vascularized composite allotransplantation
Knoedler L, Knoedler S, Panayi A, Lee C, Sadigh S, Huelsboemer L, Stoegner V, Schroeter A, Kern B, Mookerjee V, Lian C, Tullius S, Murphy G, Pomahac B, Kauke-Navarro M. Cellular activation pathways and interaction networks in vascularized composite allotransplantation. Frontiers In Immunology 2023, 14: 1179355. PMID: 37266446, PMCID: PMC10230044, DOI: 10.3389/fimmu.2023.1179355.Peer-Reviewed Original ResearchMeSH KeywordsGraft RejectionHumansImmune ToleranceImmunosuppression TherapyTransplantation, HomologousVascularized Composite AllotransplantationConceptsVascularized Composite AllotransplantationComposite allotransplantationRecipient-derived lymphocytesTreatment of patientsCellular activation pathwaysMultidrug immunosuppressionVCA graftsVCA patientsVCA rejectionGraft rejectionDevastating injuriesClinical managementNovel therapiesReconstructive surgeryLimb lossRejection responseFacial disfigurementAllotransplantationPatientsGraftActivation pathwayTissue cellsDifferent cell typesTissue typesCell typesCorrelation between facial vascularized composite allotransplantation rejection and laboratory markers: Insights from a retrospective study of eight patients
Kauke-Navarro M, Knoedler S, Panayi A, Knoedler L, Haller B, Parikh N, Huelsboemer L, Stoegner V, Kiefer J, Eisenhardt S, Azzi J, Pomahac B. Correlation between facial vascularized composite allotransplantation rejection and laboratory markers: Insights from a retrospective study of eight patients. Journal Of Plastic Reconstructive & Aesthetic Surgery 2023, 83: 155-164. PMID: 37276734, DOI: 10.1016/j.bjps.2023.04.050.Peer-Reviewed Original ResearchBiomarkersGraft RejectionHumansRetrospective StudiesTransplantation, HomologousVascularized Composite Allotransplantation
2020
Indications for and Outcomes of Endoscopic Sinus Surgery and Other Rhinologic Surgery After Facial Transplant
Haug V, Yamasaki A, Fullerton Z, Maxfield A, Pomahac B, Bergmark R, Annino D. Indications for and Outcomes of Endoscopic Sinus Surgery and Other Rhinologic Surgery After Facial Transplant. JAMA Otolaryngology - Head & Neck Surgery 2020, 146: 669-671. PMID: 32525516, PMCID: PMC7290693, DOI: 10.1001/jamaoto.2020.0774.Peer-Reviewed Original ResearchMeSH KeywordsAdultEndoscopyFacial TransplantationFemaleHumansMaleMiddle AgedParanasal SinusesReoperationRetrospective StudiesRhinoplastyTransplantation, HomologousTreatment Outcome
2019
Novel immunological and clinical insights in vascularized composite allotransplantation
Kollar B, Pomahac B, Riella L. Novel immunological and clinical insights in vascularized composite allotransplantation. Current Opinion In Organ Transplantation 2019, 24: 42-48. PMID: 30531538, DOI: 10.1097/mot.0000000000000592.Peer-Reviewed Original ResearchConceptsAcute rejectionT cellsComposite allotransplantationField of VCANovel immunosuppressive approachAntibody-mediated rejectionCurrent histological classificationNovel noninvasive biomarkersQuality of lifeType of rejectionIntensity of treatmentFace transplant recipientsChronic rejectionImmunosuppressive regimensVCA patientsVCA recipientsAllograft injuryCostimulation blockadeImmunosuppressive approachesImmunosuppressive therapyTransplant recipientsImmune monitoringUpper extremityHistological classificationVCA outcomes
2017
Chronic Allograft Deterioration: A Clinical Reality in Vascularized Composite Allotransplantation
Krezdorn N, Pomahac B. Chronic Allograft Deterioration: A Clinical Reality in Vascularized Composite Allotransplantation. American Journal Of Transplantation 2017, 17: 1703-1704. PMID: 28371193, DOI: 10.1111/ajt.14291.Peer-Reviewed Original ResearchReflections on a Decade of Face Transplantation
Giatsidis G, Sinha I, Pomahac B. Reflections on a Decade of Face Transplantation. Annals Of Surgery 2017, 265: 841-846. PMID: 28032849, DOI: 10.1097/sla.0000000000001760.Peer-Reviewed Original ResearchMeSH KeywordsAnniversaries and Special EventsFacial InjuriesFacial TransplantationFranceGraft SurvivalHumansIncidenceInjury Severity ScoreRisk AssessmentTime FactorsTransplantation, HomologousConceptsFace transplantationSci-fi novelsEthical discussionPersonal strugglesSocial beliefsFace transplantSocietal implicationsMedical discoveriesMedical innovationScienceFace restorationPublic opinionHigh-risk trajectoriesTodayLong wayMedical communityRegulatory frameworkBeliefsStruggleSocietyReflectionAnswersQuestionsDiscussionAnniversary
2015
Vascularized composite allotransplantation: current standards and novel approaches to prevent acute rejection and chronic allograft deterioration
Kueckelhaus M, Fischer S, Seyda M, Bueno E, Aycart M, Alhefzi M, ElKhal A, Pomahac B, Tullius S. Vascularized composite allotransplantation: current standards and novel approaches to prevent acute rejection and chronic allograft deterioration. Transplant International 2015, 29: 655-662. PMID: 26265179, PMCID: PMC4785085, DOI: 10.1111/tri.12652.Peer-Reviewed Original ResearchConceptsAcute rejectionImproved long-term graft outcomesLong-term graft outcomeChronic allograft deteriorationCytomegalovirus infection statusGraft preservation techniquesUpper extremity transplantationUpper extremity transplantsAntibody-mediated rejectionGood midterm resultsSpecific treatment strategiesAllograft deteriorationChronic rejectionClinical VCAVCA graftsGraft outcomeImmunosuppressive strategiesLocal immunosuppressionMidterm resultsExtremity transplantationCell-based therapiesHLA matchingTolerance inductionTreatment strategiesUS Centers
2014
Facial and Hand Allotransplantation
Pomahac B, Gobble R, Schneeberger S. Facial and Hand Allotransplantation. Cold Spring Harbor Perspectives In Medicine 2014, 4: a015651. PMID: 24478387, PMCID: PMC3935393, DOI: 10.1101/cshperspect.a015651.Peer-Reviewed Original ResearchConceptsVascularized Composite AllotransplantationFacial transplantationLong-term immunosuppressionMinimization of immunosuppressionGood functional outcomeTreatment of patientsMultidisciplinary team approachNovel therapeutic optionsSevere facial disfigurementAllograft survivalHand allotransplantationSkin rejectionTherapeutic optionsFunctional outcomeLimb lossComposite allotransplantationSide effectsTeam approachTransplantationSurgical planningFacial disfigurementImmunosuppressionAllotransplantationComplex proceduresPatients
2013
Lessons Learned from Simultaneous Face and Bilateral Hand Allotransplantation
Carty M, Hivelin M, Dumontier C, Talbot S, Benjoar M, Pribaz J, Lantieri L, Pomahac B. Lessons Learned from Simultaneous Face and Bilateral Hand Allotransplantation. Plastic & Reconstructive Surgery 2013, 132: 423-432. PMID: 23584623, DOI: 10.1097/prs.0b013e318295883d.Peer-Reviewed Original ResearchThe Case for Lower Extremity Allotransplantation
Carty M, Zuker R, Cavadas P, Pribaz J, Talbot S, Pomahac B. The Case for Lower Extremity Allotransplantation. Plastic & Reconstructive Surgery 2013, 131: 1272-1277. PMID: 23416434, DOI: 10.1097/prs.0b013e31828bd1a5.Peer-Reviewed Original ResearchMeSH KeywordsAmputeesArmGraft RejectionHumansImmunosuppressive AgentsInfantLegMaleMicrosurgeryMuscle ContractionRange of Motion, ArticularTransplantation, HomologousTreatment OutcomeYoung AdultConceptsComposite allotransplantationCurrent Principles of Facial Allotransplantation
Pomahac B, Bueno E, Sisk G, Pribaz J. Current Principles of Facial Allotransplantation. Plastic & Reconstructive Surgery 2013, 131: 1069-1076. PMID: 23629089, PMCID: PMC4374342, DOI: 10.1097/prs.0b013e3182865cd3.Peer-Reviewed Original ResearchMeSH KeywordsAdultFaceFacial TransplantationFemaleGraft RejectionHumansQuality of LifeRecovery of FunctionSalvage TherapyTransplantation, HomologousConceptsTransplant recipientsSurgical principlesFace transplant recipientsFacial allotransplantationFull screening procedureReturn of motorFace transplant candidatesFundamental surgical principlesTransplant candidatesTransplantation teamWomen's HospitalSevere casesSensory functionPatientsUnique caseAllotransplantationClinical volumeFacial disfigurementRecipientsHospitalScreening procedureFacial restorationCurrent principlesBrighamVascularized composite tissue allotransplantation – state of the art
Diaz‐Siso J, Bueno E, Sisk G, Marty F, Pomahac B, Tullius S. Vascularized composite tissue allotransplantation – state of the art. Clinical Transplantation 2013, 27: 330-337. PMID: 23581799, PMCID: PMC3724233, DOI: 10.1111/ctr.12117.Peer-Reviewed Original ResearchMeSH KeywordsHumansTransplantation ToleranceTransplantation, HomologousVascularized Composite AllotransplantationConceptsImmunosuppression-related side effectsVascularized composite tissue allotransplantationLong-term graft lossEarly post-operative periodChronic graft deteriorationPost-operative periodLong-term outcomesViable treatment optionConventional reconstructive techniquesComposite tissue allotransplantationAcute rejectionGraft lossGraft deteriorationTolerance inductionTreatment optionsLifelong immunosuppressionLower extremitiesImmune responseAnatomic locationReconstructive techniquesAbdominal wallSide effectsTissue allotransplantationFunctional restorationCellular therapy
2012
Infections Following Facial Composite Tissue Allotransplantation—Single Center Experience and Review of the Literature
Knoll B, Hammond S, Koo S, Issa N, Tullius S, Baden L, Pomahac B, Marty F. Infections Following Facial Composite Tissue Allotransplantation—Single Center Experience and Review of the Literature. American Journal Of Transplantation 2012, 13: 770-779. PMID: 23279299, DOI: 10.1111/ajt.12013.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Infective AgentsCatheter-Related InfectionsCytomegalovirusCytomegalovirus InfectionsFaceFemaleGraft RejectionGraft SurvivalHumansMaleMiddle AgedPneumoniaPostoperative ComplicationsPrognosisSurgical Wound InfectionTissue TransplantationTransplantation, HomologousTrimethoprim, Sulfamethoxazole Drug CombinationConceptsFacial composite tissue allotransplantationCMV diseaseInfectious complicationsPosttransplant infectionsClostridium difficile-associated diarrheaDiscontinuation of prophylaxisEarly posttransplant infectionsSurgical site infectionDifficile-associated diarrheaCatheter-associated infectionsComposite tissue allotransplantationInvasive dermatophyte infectionAdditional prophylaxisBacterial parotitisPerioperative prophylaxisValganciclovir treatmentCenter experienceProphylaxis strategiesSite infectionPolymicrobial bacteremiaRecipient factorsTrimethoprim-sulfamethoxazoleMedical recordsDermatophyte infectionsProphylaxisNovel Surgical Technique for Full Face Transplantation
Pomahac B, Pribaz J, Bueno E, Sisk G, Diaz-Siso J, Chandawarkar A, Westvik T, Malin E, Eriksson E. Novel Surgical Technique for Full Face Transplantation. Plastic & Reconstructive Surgery 2012, 130: 549-555. PMID: 22575856, DOI: 10.1097/prs.0b013e31825dc25c.Peer-Reviewed Original ResearchDonor Facial Composite Allograft Recovery Operation
Pomahac B, Papay F, Bueno E, Bernard S, Diaz-Siso J, Siemionow M. Donor Facial Composite Allograft Recovery Operation. Plastic & Reconstructive Surgery 2012, 129: 461e-467e. PMID: 22373994, DOI: 10.1097/prs.0b013e31824129d7.Peer-Reviewed Original ResearchBostonFacial TransplantationHumansOhioTissue and Organ ProcurementTissue DonorsTransplantation, HomologousVascularized Composite Allotransplantation Research: The Emerging Field
Pomahac B, Becker Y, Cendales L, Ildstad S, Li X, Schneeberger S, Siemionow M, Thomson A, Zheng X, Tullius S. Vascularized Composite Allotransplantation Research: The Emerging Field. American Journal Of Transplantation 2012, 12: 1062-1063. PMID: 22225551, DOI: 10.1111/j.1600-6143.2011.03900.x.Peer-Reviewed Original ResearchHumansPlastic Surgery ProceduresTissue TransplantationTransplantation ImmunologyTransplantation, HomologousThe Brigham and Women's Hospital Face Transplant Program
Singhal D, Pribaz J, Pomahac B. The Brigham and Women's Hospital Face Transplant Program. Plastic & Reconstructive Surgery 2012, 129: 81e-88e. PMID: 22186587, DOI: 10.1097/prs.0b013e31823621db.Peer-Reviewed Original Research
2011
Three Patients with Full Facial Transplantation
Pomahac B, Pribaz J, Eriksson E, Bueno E, Diaz-Siso J, Rybicki F, Annino D, Orgill D, Caterson E, Caterson S, Carty M, Chun Y, Sampson C, Janis J, Alam D, Saavedra A, Molnar J, Edrich T, Marty F, Tullius S. Three Patients with Full Facial Transplantation. New England Journal Of Medicine 2011, 366: 715-722. PMID: 22204672, DOI: 10.1056/nejmoa1111432.Peer-Reviewed Original ResearchConceptsFull face transplantFull facial transplantationFacial transplantationAcute rejectionPostoperative complicationsSensory nervesSevere deformityFunctional restorationPatientsSingle episodeFacial allograftTransplantationFacial appearanceConventional reconstructionComplicationsAllograftsNerveGlucocorticoidsTransplantDeformityCoaptationMonthsA Position Paper in Support of Hand Transplantation in the Blind
Carty M, Bueno E, Lehmann L, Pomahac B. A Position Paper in Support of Hand Transplantation in the Blind. Plastic & Reconstructive Surgery 2011, 128: 510e-515e. PMID: 22030511, DOI: 10.1097/prs.0b013e31822b62e7.Peer-Reviewed Original ResearchConceptsHand transplantationPreoperative Vascular Mapping for Facial Allotransplantation
Soga S, Pomahac B, Mitsouras D, Kumamaru K, Powers S, Prior R, Signorelli J, Bueno E, Steigner M, Rybicki F. Preoperative Vascular Mapping for Facial Allotransplantation. Plastic & Reconstructive Surgery 2011, 128: 883-891. PMID: 21921764, DOI: 10.1097/prs.0b013e3182268b43.Peer-Reviewed Original Research