2018
Increased levels of circulating MMP3 correlate with severe rejection in face transplantation
Kollar B, Shubin A, Borges T, Tasigiorgos S, Win T, Lian C, Dillon S, Gu X, Wyrobnik I, Murphy G, Pomahac B, Libermann T, Riella L. Increased levels of circulating MMP3 correlate with severe rejection in face transplantation. Scientific Reports 2018, 8: 14915. PMID: 30297859, PMCID: PMC6175842, DOI: 10.1038/s41598-018-33272-7.Peer-Reviewed Original ResearchConceptsSevere rejectionFace transplantationLarge independent patient cohortsAcute rejection episodesAnti-rejection treatmentFirst postoperative yearLongitudinal serum samplesNon-invasive candidate biomarkersViable treatment optionSOMAscan proteomics platformIndependent patient cohortsFace transplant recipientsRejection episodesPostoperative yearTransplant recipientsDevastating injuriesMMP3 levelsTransplant rejectionHistological gradePatient cohortTreatment optionsSurrogate markerMMP3 proteinCandidate biomarkersTransplantation
2016
Long-Term Effects of the Collagenase of the Bacterium Clostridium histolyticum for the Treatment of Capsular Fibrosis After Silicone Implants
Fischer S, Diehm Y, Henzler T, Berger M, Kolbenschlag J, Latz A, Bueno E, Hirche C, Kneser U, Pomahac B. Long-Term Effects of the Collagenase of the Bacterium Clostridium histolyticum for the Treatment of Capsular Fibrosis After Silicone Implants. Aesthetic Plastic Surgery 2016, 41: 211-220. PMID: 28008464, DOI: 10.1007/s00266-016-0724-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiopsy, NeedleBreast ImplantationBreast ImplantsClostridium histolyticumDisease Models, AnimalFemaleFibrosisHumansImmunohistochemistryImplant Capsular ContractureInjections, IntralesionalMagnetic Resonance ImagingMicrobial CollagenasePregnancyRandom AllocationRatsRats, Inbred LewReal-Time Polymerase Chain ReactionReference ValuesSilicone GelsTreatment OutcomeUltrasonography, DopplerConceptsMagnetic resonance imagingBacterium Clostridium histolyticumSilicone implantsCapsular fibrosisCollagenase injectionTreatment groupsSkin perforationFrequent long-term complicationMethodsForty-eight ratsMiniature silicone implantsLong-term complicationsClostridium histolyticumViable treatment optionLevel of evidenceHigh-resolution ultrasoundCapsule thicknessInjection of collagenaseExpression levelsDays post injectionLevel AssignedThis journalLong-term effectivenessBackgroundCapsular contractureAnti-fibrotic genesTreatment optionsImplant pocket
2013
Vascularized composite tissue allotransplantation – state of the art
Diaz‐Siso J, Bueno E, Sisk G, Marty F, Pomahac B, Tullius S. Vascularized composite tissue allotransplantation – state of the art. Clinical Transplantation 2013, 27: 330-337. PMID: 23581799, PMCID: PMC3724233, DOI: 10.1111/ctr.12117.Peer-Reviewed Original ResearchConceptsImmunosuppression-related side effectsVascularized composite tissue allotransplantationLong-term graft lossEarly post-operative periodChronic graft deteriorationPost-operative periodLong-term outcomesViable treatment optionConventional reconstructive techniquesComposite tissue allotransplantationAcute rejectionGraft lossGraft deteriorationTolerance inductionTreatment optionsLifelong immunosuppressionLower extremitiesImmune responseAnatomic locationReconstructive techniquesAbdominal wallSide effectsTissue allotransplantationFunctional restorationCellular therapy