2023
Cellular activation pathways and interaction networks in vascularized composite allotransplantation
Knoedler L, Knoedler S, Panayi A, Lee C, Sadigh S, Huelsboemer L, Stoegner V, Schroeter A, Kern B, Mookerjee V, Lian C, Tullius S, Murphy G, Pomahac B, Kauke-Navarro M. Cellular activation pathways and interaction networks in vascularized composite allotransplantation. Frontiers In Immunology 2023, 14: 1179355. PMID: 37266446, PMCID: PMC10230044, DOI: 10.3389/fimmu.2023.1179355.Peer-Reviewed Original ResearchConceptsVascularized Composite AllotransplantationComposite allotransplantationRecipient-derived lymphocytesTreatment of patientsCellular activation pathwaysMultidrug immunosuppressionVCA graftsVCA patientsVCA rejectionGraft rejectionDevastating injuriesClinical managementNovel therapiesReconstructive surgeryLimb lossRejection responseFacial disfigurementAllotransplantationPatientsGraftActivation pathwayTissue cellsDifferent cell typesTissue typesCell types
2022
Cytomegalovirus-related Complications and Management in Facial Vascularized Composite Allotransplantation: An International Multicenter Retrospective Cohort Study
Kauke-Navarro M, Panayi AC, Formica R, Marty F, Parikh N, Foroutanjazi S, Safi AF, Mardini S, Razonable RR, Morelon E, Gelb B, Rodriguez E, Lassus P, Pomahac B. Cytomegalovirus-related Complications and Management in Facial Vascularized Composite Allotransplantation: An International Multicenter Retrospective Cohort Study. Transplantation 2022, 106: 2031-2043. PMID: 35389381, DOI: 10.1097/tp.0000000000004132.Peer-Reviewed Original ResearchConceptsRetrospective cohort studyAntiviral prophylaxisCohort studyComposite allotransplantationInternational multicenter retrospective cohort studyMulticenter retrospective cohort studyCMV-related complicationsFirst year posttransplantHigh-risk transplantsMore rejection episodesHigh-risk groupFacial Vascularized Composite AllotransplantationAllograft-related complicationsVascularized Composite AllotransplantationPaucity of dataAllograft lossCMV diseaseCMV viremiaCytomegalovirus serostatusR serostatusRejection episodesCMV infectionPrompt treatmentActive surveillancePatients
2020
Defining chronic rejection in vascularized composite allotransplantation—The American Society of Reconstructive Transplantation and International Society of Vascularized Composite Allotransplantation chronic rejection working group: 2018 American Society of Reconstructive Transplantation meeting report and white paper Research goals in defining chronic rejection in vascularized composite allotransplantation
Kaufman C, Kanitakis J, Weissenbacher A, Brandacher G, Mehra M, Amer H, Zelger B, Zelger B, Pomahac B, McDiarmid S, Cendales L, Morelon E. Defining chronic rejection in vascularized composite allotransplantation—The American Society of Reconstructive Transplantation and International Society of Vascularized Composite Allotransplantation chronic rejection working group: 2018 American Society of Reconstructive Transplantation meeting report and white paper Research goals in defining chronic rejection in vascularized composite allotransplantation. SAGE Open Medicine 2020, 8: 2050312120940421. PMID: 32704373, PMCID: PMC7361482, DOI: 10.1177/2050312120940421.Peer-Reviewed Original ResearchChronic rejectionComposite allograftsFunctional declineReconstructive transplantationComposite allotransplantationHistologic evidenceDe novo donor-specific antibodiesAmerican SocietyNovo donor-specific antibodiesNormal allograft functionDonor-specific antibodiesInternational SocietyVascularized Composite AllotransplantationAcute rejectionAllograft functionAllograft recipientsImmunosuppressive therapyTreatment regimensRisk factorsUterine transplantationUpper extremityMeeting reportAllograftsTransplantationClinical cases
2018
Extracorporeal Perfusion in Vascularized Composite Allotransplantation
Kueckelhaus M, Puscz F, Dermietzel A, Dadras M, Fischer S, Krezdorn N, Pomahac B, Hirsch T. Extracorporeal Perfusion in Vascularized Composite Allotransplantation. Annals Of Plastic Surgery 2018, 80: 669-678. PMID: 29746324, DOI: 10.1097/sap.0000000000001477.Peer-Reviewed Original ResearchConceptsVascularized Composite AllotransplantationSolid organ transplantationIschemia timeMachine perfusionOrgan transplantationReconstructive surgeryComposite allotransplantationClinical solid organ transplantationMachine perfusion systemImmunosuppressive treatmentGraft immunogenicityBroad clinical applicationLifelong monitoringTherapeutic measuresPerfusion strategyClinical successSevere injuriesPerfusion solutionPreclinical trialsClinical settingPlastic surgeryPerfusionImmunogenicityPerfusion systemClinical applicationFacial Transplantation
Aycart M, Pomahac B. Facial Transplantation. DeckerMed Plastic Surgery 2018 DOI: 10.2310/ps.10073.Peer-Reviewed Original ResearchFacial transplantationMicrosurgical reconstructive techniquesShort-term resultsComposite tissue transplantationVascularized Composite AllotransplantationQuality of lifeConventional therapyFunctional outcomeTransplant surgeryLate outcomesReconstructive techniquesComposite allotransplantationTransplantationTissue transplantationNeck defectsClinical realityMedical communityRecipient evaluationImmunosuppressionCraniofacial surgerySurgeryComplex headOutcomesKey wordsMore experience
2017
Role of Facial Vascularized Composite Allotransplantation in Burn Patients
Bharadia D, Sinha I, Pomahac B. Role of Facial Vascularized Composite Allotransplantation in Burn Patients. Clinics In Plastic Surgery 2017, 44: 857-864. PMID: 28888310, DOI: 10.1016/j.cps.2017.05.017.Peer-Reviewed Original ResearchConceptsComposite allotransplantationFacial Vascularized Composite AllotransplantationExtensive burn injuriesRisk of rejectionVascularized Composite AllotransplantationQuality of lifeLifelong regimenVCA patientsImmunosuppression medicationsPowerful reconstructive toolsBurn patientsTreatment optionsSurgical techniqueBurn injuryReconstructive surgeryPatientsReconstructive toolFace transplantationAllotransplantationImproved qualityFacial formImmunosuppressionMedicationsRegimenSurgeryChronic Allograft Deterioration: A Clinical Reality in Vascularized Composite Allotransplantation
Krezdorn N, Pomahac B. Chronic Allograft Deterioration: A Clinical Reality in Vascularized Composite Allotransplantation. American Journal Of Transplantation 2017, 17: 1703-1704. PMID: 28371193, DOI: 10.1111/ajt.14291.Peer-Reviewed Original ResearchConceptsComposite allotransplantationSolid organ transplantationVascularized Composite AllotransplantationCase reportOrgan transplantationClinical realityAllotransplantation
2016
Treatment of Rejection in Vascularized Composite Allotransplantation
Alhefzi M, Aycart M, Bueno E, Kiwanuka H, Krezdorn N, Pomahac B, Tullius S. Treatment of Rejection in Vascularized Composite Allotransplantation. Current Transplantation Reports 2016, 3: 404-409. DOI: 10.1007/s40472-016-0128-3.Peer-Reviewed Original ResearchVascularized Composite AllotransplantationAcute rejectionChronic rejectionComposite allotransplantationTreatment of rejectionConventional reconstructive techniquesCommon complicationReconstructive techniquesEsthetic outcomeTherapeutic strategiesImportant modalityAllotransplantationRecent reportsTreatmentRejectionAllograftsComplicationsPrevention2530: Unilateral facial artery is sufficient for vascularized composite allotransplantation of the lower two-thirds of the face - Case report on a face transplant recipient at the Brigham and Women's Hospital
Fischer S, Lee T, Krezdorn N, Alhefzi M, Aycart M, Kiwanuka H, Win T, Bueno E, Tullius S, Pomahac B. 2530: Unilateral facial artery is sufficient for vascularized composite allotransplantation of the lower two-thirds of the face - Case report on a face transplant recipient at the Brigham and Women's Hospital. Vascularized Composite Allotransplantation 2016, 3: 44-44. DOI: 10.1080/23723505.2016.1234256.Peer-Reviewed Original ResearchVascularized Composite AllotransplantationFace transplant recipientsTransplant recipientsWomen's HospitalComposite allotransplantationFacial arteryHospitalTwo-thirdsAllotransplantation
2014
Facial and Hand Allotransplantation
Pomahac B, Gobble R, Schneeberger S. Facial and Hand Allotransplantation. Cold Spring Harbor Perspectives In Medicine 2014, 4: a015651. PMID: 24478387, PMCID: PMC3935393, DOI: 10.1101/cshperspect.a015651.Peer-Reviewed Original ResearchConceptsVascularized Composite AllotransplantationFacial transplantationLong-term immunosuppressionMinimization of immunosuppressionGood functional outcomeTreatment of patientsMultidisciplinary team approachNovel therapeutic optionsSevere facial disfigurementAllograft survivalHand allotransplantationSkin rejectionTherapeutic optionsFunctional outcomeLimb lossComposite allotransplantationSide effectsTeam approachTransplantationSurgical planningFacial disfigurementImmunosuppressionAllotransplantationComplex proceduresPatientsThe Advent of the Restorative Plastic Surgeon
Carty M, Pribaz J, Talbot S, Caterson E, Pomahac B. The Advent of the Restorative Plastic Surgeon. Plastic & Reconstructive Surgery 2014, 133: 182-186. PMID: 24374677, DOI: 10.1097/01.prs.0000436806.35294.e0.Peer-Reviewed Original ResearchConceptsPlastic surgeonsVascularized Composite AllotransplantationClinical identityReconstructive plastic surgeon
2013
Vascularized Composite Allotransplantation and Tissue Engineering
Bueno E, Diaz-Siso J, Sisk G, Chandawarkar A, Kiwanuka H, Lamparello B, Caterson E, Pomahac B. Vascularized Composite Allotransplantation and Tissue Engineering. Journal Of Craniofacial Surgery 2013, 24: 256-263. PMID: 23348296, DOI: 10.1097/scs.0b013e318275f173.Peer-Reviewed Original ResearchConceptsTissue engineeringComposite tissue defectsTissue engineersVascularized Composite AllotransplantationDemonstrated resultsComposite tissueEngineeringTE researchImmune suppressionLifelong immune suppressionComposite allotransplantationAnatomic equivalentsTissue defectsBiomaterialsRegenerative medicineBioreactorCenter experienceExtremity amputationConventional reconstructionEngineersDonor shortageCompatible donorsFacial injuriesClinical practice