2018
Increased levels of circulating MMP3 correlate with severe rejection in face transplantation
Kollar B, Shubin A, Borges T, Tasigiorgos S, Win T, Lian C, Dillon S, Gu X, Wyrobnik I, Murphy G, Pomahac B, Libermann T, Riella L. Increased levels of circulating MMP3 correlate with severe rejection in face transplantation. Scientific Reports 2018, 8: 14915. PMID: 30297859, PMCID: PMC6175842, DOI: 10.1038/s41598-018-33272-7.Peer-Reviewed Original ResearchConceptsSevere rejectionFace transplantationLarge independent patient cohortsAcute rejection episodesAnti-rejection treatmentFirst postoperative yearLongitudinal serum samplesNon-invasive candidate biomarkersViable treatment optionSOMAscan proteomics platformIndependent patient cohortsFace transplant recipientsRejection episodesPostoperative yearTransplant recipientsDevastating injuriesMMP3 levelsTransplant rejectionHistological gradePatient cohortTreatment optionsSurrogate markerMMP3 proteinCandidate biomarkersTransplantation
2015
Utility of Sentinel Flaps in Assessing Facial Allograft Rejection
Kueckelhaus M, Fischer S, Lian C, Bueno E, Marty F, Tullius S, Pribaz J, Murphy G, Pomahac B. Utility of Sentinel Flaps in Assessing Facial Allograft Rejection. Plastic & Reconstructive Surgery 2015, 135: 250-258. PMID: 25255116, DOI: 10.1097/prs.0000000000000797.Peer-Reviewed Original ResearchConceptsFacial allograftRejection monitoringFasciocutaneous radial forearm flapCLINICAL QUESTION/LEVELSevere rejection episodesFurther surgical proceduresFacial allotransplantationFree fasciocutaneous radial forearm flapRadial forearm flapAxial blood supplyFunctional flapNonfacial sitesRejection episodesLimited skin areaSevere rejectionAllograft rejectionClinical findingsFacial dermatitisFrequent biopsiesBiopsy pairsBiopsy specimensHistologic evaluationSkin biopsiesBlood supplySurgical procedures