2022
Jejunoileal mucosal growth in mice with a limited microbiome
Shaughnessy MP, Park CJ, Salvi PS, Cowles RA. Jejunoileal mucosal growth in mice with a limited microbiome. PLOS ONE 2022, 17: e0266251. PMID: 35349599, PMCID: PMC8963542, DOI: 10.1371/journal.pone.0266251.Peer-Reviewed Original ResearchConceptsIntestinal mucosal growthMucosal surface areaSmall intestinal mucosal growthCrypt proliferation indexCONV miceGF miceMucosal growthVillus heightEnteral antibioticsCrypt depthCell proportionSmall intestinal villus heightGerm-free miceBroad-spectrum antibioticsConventional floraIntestinal villus heightGerm-free conditionsEnteral administrationMucosal homeostasisGnotobiotic miceProliferation indexEnterocyte proliferationMiceTaller villiGF conditions
2019
Orally Dosed Citalopram Stimulates Small Intestinal Mucosal Growth
Zhang L, Greig CJ, Cowles RA. Orally Dosed Citalopram Stimulates Small Intestinal Mucosal Growth. Journal Of Surgical Research 2019, 236: 326-331. PMID: 30694773, DOI: 10.1016/j.jss.2018.11.033.Peer-Reviewed Original ResearchConceptsMucosal surface areaSelective serotonin reuptake inhibitorsSerotonin reuptake inhibitorsIntestinal mucosal growthVillus heightVillus widthD citalopramReuptake inhibitorsMucosal growthCrypt depthCrypt widthSmall intestinal mucosal growthShort bowel syndromeT-testSerious intestinal disordersStudent's t-testOral agentsBowel syndromeOral therapyEnteral administrationC57BL/6 miceIleal segmentIntestinal disordersDay 21Day 7