2005
Nicotine induces mitogen-activated protein kinase dependent vascular smooth muscle cell migration
Di Luozzo G, Pradhan S, Dhadwal AK, Chen A, Ueno H, Sumpio BE. Nicotine induces mitogen-activated protein kinase dependent vascular smooth muscle cell migration. Atherosclerosis 2005, 178: 271-277. PMID: 15694934, DOI: 10.1016/j.atherosclerosis.2004.09.017.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cell migrationSmooth muscle cell migrationMuscle cell migrationInhibitors of p38VSMC migrationMitogen-activated protein kinaseEndothelial cellsDevelopment of atherosclerosisEffects of nicotineCell migrationWestern blotting methodInjury modelVascular endotheliumCigarette smokeBoyden chamber chemotaxis assaysAortic VSMCsChemotactic effectMAPKs p38NicotineChemoattractant moleculesChemotaxis assaysCellular mechanismsUltrastructural changesVSMCP44/42 activation
2000
Vascular smooth muscle cell effect on endothelial cell endothelin-1 production
Di Luozzo G, Bhargava J, Powell R. Vascular smooth muscle cell effect on endothelial cell endothelin-1 production. Journal Of Vascular Surgery 2000, 31: 781-789. PMID: 10753286, DOI: 10.1067/mva.2000.103788.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsET-1 productionEndothelin-1SMC proliferationEndothelial cellsNitro-L-arginine methyl esterNitric oxide synthase activityEC stimulationEndothelin-1 productionVascular lesion developmentNO synthase inhibitorOxide synthase activityEffects of SMCEts-1 proteinReceptor blockersCo-culture modelSMC inhibitionSynthase inhibitorLesion developmentB receptorMuscle cellsPotent mitogenRNA levelsProtein levelsPutative factors