2021
Executive functioning-specific behavioral impairments in a rat model of human third trimester binge drinking implicate prefrontal-thalamo-hippocampal circuitry in Fetal Alcohol Spectrum Disorders
Gursky ZH, Savage LM, Klintsova AY. Executive functioning-specific behavioral impairments in a rat model of human third trimester binge drinking implicate prefrontal-thalamo-hippocampal circuitry in Fetal Alcohol Spectrum Disorders. Behavioural Brain Research 2021, 405: 113208. PMID: 33640395, PMCID: PMC8005484, DOI: 10.1016/j.bbr.2021.113208.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBehavior, AnimalBinge DrinkingCentral Nervous System DepressantsCognitive DysfunctionDisease Models, AnimalEthanolExecutive FunctionFemaleFetal Alcohol Spectrum DisordersHypothalamusMaleNerve NetPrefrontal CortexPregnancyPregnancy Trimester, ThirdRatsRats, Long-EvansThalamusConceptsExecutive functioningFetal alcohol spectrum disordersNovel object recognitionPrenatal alcohol exposureBehavioral impairmentsSpectrum disorderAlcohol spectrum disordersPrefrontal cortexObject recognitionBehavioral flexibility tasksSpontaneous alternationPlus-maze taskMedial prefrontal cortexAlcohol exposureThalamic nucleus reuniensAlcohol-exposed ratsLong-Evans rat pupsFlexibility taskReversal learningDiscrimination learningSham intubationsBehavioral alterationsDevelopmental alcoholAssociative memoryMaze task
2017
Chapter 15 Frontal Lobe Dysfunction After Developmental Alcohol Exposure Implications From Animal Models
Gursky Z, Klintsova A. Chapter 15 Frontal Lobe Dysfunction After Developmental Alcohol Exposure Implications From Animal Models. 2017, 139-147. DOI: 10.1016/b978-0-12-805373-7.00015-3.ChaptersFetal alcohol spectrum disordersFrontal lobe damageFrontal lobeFrontal lobe dysfunctionAberrant cortical connectivityAlcohol exposureAtypical developmentReversal learningSpectrum disorderAlcohol spectrum disordersBehavioral flexibilityAnimal literatureNeuroanatomical damageCortical connectivityBehavioral deficitsCortical damagePhysical impairmentPrenatal exposureQuality of lifeThird trimesterExposure implicationsFurther researchRodent modelsHuman gestationAnimal models