2023
Continuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport
Ozturk B, Koundal S, Al Bizri E, Chen X, Gursky Z, Dai F, Lim A, Heerdt P, Kipnis J, Tannenbaum A, Lee H, Benveniste H. Continuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport. JCI Insight 2023, 8: e170270. PMID: 37159262, PMCID: PMC10371231, DOI: 10.1172/jci.insight.170270.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressurePositive airway pressureGlymphatic transportAirway pressureIntracranial pressureEnd-expiratory lung volumeCSF bulk flowCerebrospinal fluid flowArterial oxygenationUpper airwayLung volumeCPAP deviceRespiratory functionClearance functionTherapeutic benefitSkull baseAnesthetized rodentsCSF flowFluid homeostasisPhysiological testingLymphatic systemFunctional crosstalkClinical devicesAirwayRats
2017
Wheel Running and Environmental Complexity as a Therapeutic Intervention in an Animal Model of FASD.
Gursky ZH, Klintsova AY. Wheel Running and Environmental Complexity as a Therapeutic Intervention in an Animal Model of FASD. Journal Of Visualized Experiments 2017 PMID: 28190057, PMCID: PMC5407705, DOI: 10.3791/54947.Peer-Reviewed Original ResearchConceptsAnimal modelsTherapeutic interventionsAge-related neurodegenerationAdult hippocampusNeurotrophic factorAdult neurogenesisAerobic exercisePrenatal exposureRodent modelsPowerful therapeutic interventionNeuroplastic potentialNeurological disordersSubcortical structuresNeuroanatomical aspectsWheel runningInterventionRodentsHippocampusRatsNeurogenesisNew cellsNeurodegenerationBrain