2023
Comparison of the prognostic value between quantification and visual estimation of coronary calcification from attenuation CT in patients undergoing SPECT myocardial perfusion imaging
Feher A, Pieszko K, Shanbhag A, Lemley M, Miller R, Huang C, Miras L, Liu Y, Gerber J, Sinusas A, Miller E, Slomka P. Comparison of the prognostic value between quantification and visual estimation of coronary calcification from attenuation CT in patients undergoing SPECT myocardial perfusion imaging. The International Journal Of Cardiovascular Imaging 2023, 40: 185-193. PMID: 37845406, PMCID: PMC466934, DOI: 10.1007/s10554-023-02980-1.Peer-Reviewed Original ResearchMeSH KeywordsAgedCalcinosisCoronary Artery DiseaseFemaleHumansMaleMiddle AgedMyocardial Perfusion ImagingPredictive Value of TestsPrognosisTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedConceptsMajor adverse cardiovascular eventsCoronary artery calcificationMyocardial perfusion imagingCT myocardial perfusion imagingSPECT/CT myocardial perfusion imagingArtery calcificationPrognostic valuePrior coronary stentingAdverse cardiovascular eventsSimilar prognostic valueSPECT myocardial perfusionREFINE SPECT registrySPECT/CTCardiovascular eventsCAC scoringCalcium scoreCoronary calcificationCoronary stentingPrognostic utilitySingle centerCoronary arteryLow doseMyocardial perfusionPerfusion imagingSurvival analysis
2022
Integration of coronary artery calcium scoring from CT attenuation scans by machine learning improves prediction of adverse cardiovascular events in patients undergoing SPECT/CT myocardial perfusion imaging
Feher A, Pieszko K, Miller R, Lemley M, Shanbhag A, Huang C, Miras L, Liu YH, Sinusas AJ, Miller EJ, Slomka PJ. Integration of coronary artery calcium scoring from CT attenuation scans by machine learning improves prediction of adverse cardiovascular events in patients undergoing SPECT/CT myocardial perfusion imaging. Journal Of Nuclear Cardiology 2022, 30: 590-603. PMID: 36195826, DOI: 10.1007/s12350-022-03099-x.Peer-Reviewed Original ResearchMeSH KeywordsAgedCalciumCoronary Artery DiseaseFemaleHumansMachine LearningMaleMiddle AgedMyocardial Perfusion ImagingPrognosisTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedConceptsMajor adverse cardiovascular eventsMyocardial perfusion imagingAdverse cardiovascular eventsSPECT myocardial perfusion imagingCAC scoringCardiovascular eventsPrediction of MACECoronary artery calcification (CAC) scoringMACE-free survivalClinical risk factorsCoronary artery calciumCT myocardial perfusion imagingReceiver operator characteristic curveSPECT/CT myocardial perfusion imagingSPECT/CTOperator characteristic curveCT myocardial perfusionArtery calciumCAC scoreAnalysis patientsMACE predictionSingle centerHigher event ratesRisk factorsRisk scoreDeep-learning-based estimation of attenuation map improves attenuation correction performance over direct attenuation estimation for myocardial perfusion SPECT
Du Y, Shang J, Sun J, Wang L, Liu YH, Xu H, Mok GSP. Deep-learning-based estimation of attenuation map improves attenuation correction performance over direct attenuation estimation for myocardial perfusion SPECT. Journal Of Nuclear Cardiology 2022, 30: 1022-1037. PMID: 36097242, DOI: 10.1007/s12350-022-03092-4.Peer-Reviewed Original ResearchDeep LearningHumansImage Processing, Computer-AssistedPerfusionRetrospective StudiesTechnetium Tc 99m SestamibiTomography, Emission-Computed, Single-PhotonDeep learning-based denoising in projection-domain and reconstruction-domain for low-dose myocardial perfusion SPECT
Sun J, Jiang H, Du Y, Li C, Wu T, Liu Y, Yang B, Mok G. Deep learning-based denoising in projection-domain and reconstruction-domain for low-dose myocardial perfusion SPECT. Journal Of Nuclear Cardiology 2022, 30: 970-985. PMID: 35982208, DOI: 10.1007/s12350-022-03045-x.Peer-Reviewed Original ResearchMeSH KeywordsDeep LearningHumansImage Processing, Computer-AssistedPerfusionPhantoms, ImagingRetrospective StudiesSingle Photon Emission Computed Tomography Computed TomographyTechnetium Tc 99m SestamibiTomography, Emission-Computed, Single-PhotonConceptsConditional generative adversarial networkGenerative adversarial networkImage qualityAdversarial networkOS-EM methodList-mode dataXCAT phantomPost-reconstruction filteringImagesSPECT projectionsDenoisingMyocardial perfusion SPECTHigh noise levelsPerfusion SPECTFull doseSPECT/CT scansNetworkDifferent anatomical variationsMode dataFilteringMP-SPECTLD imagesIncreasing angular sampling through deep learning for stationary cardiac SPECT image reconstruction
Xie H, Thorn S, Chen X, Zhou B, Liu H, Liu Z, Lee S, Wang G, Liu YH, Sinusas AJ, Liu C. Increasing angular sampling through deep learning for stationary cardiac SPECT image reconstruction. Journal Of Nuclear Cardiology 2022, 30: 86-100. PMID: 35508796, DOI: 10.1007/s12350-022-02972-z.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDeep LearningHumansImage Processing, Computer-AssistedPhantoms, ImagingSwineTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedConceptsDeep learningReconstruction qualityImage reconstructionDeep learning methodsDeep neural networksDeep learning resultsImage qualityNetwork trainingSPECT image reconstructionNeural networkLearning methodsHigh image resolutionImage volumesClinical softwareImage metricsImage resolutionReconstruction resultsImproved image qualityTesting dataLearning resultsNetwork resultsPhysical phantomStationary imagingDifferent subjectsLearningCross-vender, cross-tracer, and cross-protocol deep transfer learning for attenuation map generation of cardiac SPECT
Chen X, Pretorius P, Zhou B, Liu H, Johnson K, Liu YH, King MA, Liu C. Cross-vender, cross-tracer, and cross-protocol deep transfer learning for attenuation map generation of cardiac SPECT. Journal Of Nuclear Cardiology 2022, 29: 3379-3391. PMID: 35474443, PMCID: PMC11407548, DOI: 10.1007/s12350-022-02978-7.Peer-Reviewed Original ResearchHumansMachine LearningRadiopharmaceuticalsSingle Photon Emission Computed Tomography Computed TomographyTechnetium Tc 99m SestamibiTomography, Emission-Computed, Single-PhotonDirect and indirect strategies of deep-learning-based attenuation correction for general purpose and dedicated cardiac SPECT
Chen X, Zhou B, Xie H, Shi L, Liu H, Holler W, Lin M, Liu YH, Miller EJ, Sinusas AJ, Liu C. Direct and indirect strategies of deep-learning-based attenuation correction for general purpose and dedicated cardiac SPECT. European Journal Of Nuclear Medicine And Molecular Imaging 2022, 49: 3046-3060. PMID: 35169887, PMCID: PMC9253078, DOI: 10.1007/s00259-022-05718-8.Peer-Reviewed Original Research
2021
Post-reconstruction attenuation correction for SPECT myocardium perfusion imaging facilitated by deep learning-based attenuation map generation
Liu H, Wu J, Shi L, Liu Y, Miller E, Sinusas A, Liu YH, Liu C. Post-reconstruction attenuation correction for SPECT myocardium perfusion imaging facilitated by deep learning-based attenuation map generation. Journal Of Nuclear Cardiology 2021, 29: 2881-2892. PMID: 34671940, DOI: 10.1007/s12350-021-02817-1.Peer-Reviewed Original ResearchDeep LearningHumansImage Processing, Computer-AssistedMyocardial Perfusion ImagingMyocardiumSensitivity and SpecificityTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedDiagnostic accuracy of stress-only myocardial perfusion SPECT improved by deep learning
Liu H, Wu J, Miller EJ, Liu C, Yaqiang, Liu, Liu YH. Diagnostic accuracy of stress-only myocardial perfusion SPECT improved by deep learning. European Journal Of Nuclear Medicine And Molecular Imaging 2021, 48: 2793-2800. PMID: 33511425, DOI: 10.1007/s00259-021-05202-9.Peer-Reviewed Original ResearchMeSH KeywordsCoronary Artery DiseaseDeep LearningFemaleHumansMaleMyocardial Perfusion ImagingPerfusionRetrospective StudiesSensitivity and SpecificityTomography, Emission-Computed, Single-PhotonConceptsMyocardial perfusion imagingCoronary artery diseaseMyocardial perfusion abnormalitiesPerfusion abnormalitiesDiagnostic accuracyConvolutional neural networkTomography myocardial perfusion imagingYale-New Haven HospitalMyocardial perfusion defect sizeSPECT myocardial perfusion imagingAbnormal myocardial perfusionReceiver-operating characteristic curvePerfusion defect sizeNew Haven HospitalAUC valuesSingle photon emissionMyocardial perfusion SPECTDeep learningHigh diagnostic accuracyArtery diseaseDL methodsFinal diagnosisPatient genderMyocardial perfusionPerfusion SPECT
2020
Anger recall mental stress decreases 123I-metaiodobenzylguanidine (123I-MIBG) uptake and increases heterogeneity of cardiac sympathetic activity in the myocardium in patients with ischemic cardiomyopathy
Avendaño R, Hashemi-Zonouz T, Sandoval V, Liu C, Burg M, Sinusas AJ, Lampert R, Liu YH. Anger recall mental stress decreases 123I-metaiodobenzylguanidine (123I-MIBG) uptake and increases heterogeneity of cardiac sympathetic activity in the myocardium in patients with ischemic cardiomyopathy. Journal Of Nuclear Cardiology 2020, 29: 798-809. PMID: 33034036, DOI: 10.1007/s12350-020-02372-1.Peer-Reviewed Original ResearchMeSH Keywords3-IodobenzylguanidineAngerArrhythmias, CardiacCardiomyopathiesHeartHumansIodine RadioisotopesMaleMyocardial IschemiaMyocardiumRadiopharmaceuticalsStress, PsychologicalSympathetic Nervous SystemTomography, Emission-Computed, Single-PhotonConceptsSympathetic activityIschemic cardiomyopathyVentricular arrhythmiasICM patientsMental stressAge-matched healthy male controlsCardiac sympathetic activityHealthy control subjectsMyocardial sympathetic activityHealthy male controlsMental stress taskSPECT/CTMediastinal ratioControl subjectsHemodynamic responseAnger recallMyocardial perfusionNormal subjectsMale controlsPatientsPerfusionPsychological stressorsArrhythmiasStress taskDual-isotope imagingDeep learning-based attenuation map generation for myocardial perfusion SPECT
Shi L, Onofrey JA, Liu H, Liu YH, Liu C. Deep learning-based attenuation map generation for myocardial perfusion SPECT. European Journal Of Nuclear Medicine And Molecular Imaging 2020, 47: 2383-2395. PMID: 32219492, DOI: 10.1007/s00259-020-04746-6.Peer-Reviewed Original ResearchMeSH KeywordsArtifactsDeep LearningHumansImage Processing, Computer-AssistedPerfusionTomography, Emission-Computed, Single-PhotonTomography, X-Ray Computed
2013
New Approach to Quantification of Molecularly Targeted Radiotracer Uptake from Hybrid Cardiac SPECT/CT: Methodology and Validation
Li S, Sinusas AJ, Dobrucki LW, Liu YH. New Approach to Quantification of Molecularly Targeted Radiotracer Uptake from Hybrid Cardiac SPECT/CT: Methodology and Validation. Journal Of Nuclear Medicine 2013, 54: 2175-2181. PMID: 24221992, DOI: 10.2967/jnumed.113.123208.Peer-Reviewed Original Research
2011
Accuracy and Reproducibility of Absolute Quantification of Myocardial Focal Tracer Uptake from Molecularly Targeted SPECT/CT: A Canine Validation
Liu YH, Sahul Z, Weyman CA, Dione DP, Dobrucki WL, Mekkaoui C, Brennan MP, Ryder WJ, Sinusas AJ. Accuracy and Reproducibility of Absolute Quantification of Myocardial Focal Tracer Uptake from Molecularly Targeted SPECT/CT: A Canine Validation. Journal Of Nuclear Medicine 2011, 52: 453-460. PMID: 21321271, PMCID: PMC3137905, DOI: 10.2967/jnumed.110.082214.Peer-Reviewed Original ResearchAnimalsDogsFemaleHeartImage Interpretation, Computer-AssistedMaleMetabolic Clearance RateMolecular ImagingMyocardial Perfusion ImagingMyocardiumRadiopharmaceuticalsReproducibility of ResultsSensitivity and SpecificitySubtraction TechniqueTissue DistributionTomography, Emission-Computed, Single-PhotonTomography, X-Ray Computed
2009
A novel three‐dimensional image reconstruction method for near‐field coded aperture single photon emission computerized tomography
Mu Z, Hong B, Li S, Liu Y. A novel three‐dimensional image reconstruction method for near‐field coded aperture single photon emission computerized tomography. Medical Physics 2009, 36: 1533-1542. PMID: 19544769, PMCID: PMC2832028, DOI: 10.1118/1.3103490.Peer-Reviewed Original ResearchAlgorithmsImage EnhancementImage Interpretation, Computer-AssistedImaging, Three-DimensionalPhantoms, ImagingReproducibility of ResultsSensitivity and SpecificityTomography, Emission-Computed, Single-Photon
2007
Quantification of nuclear cardiac images: The Yale approach
Liu YH. Quantification of nuclear cardiac images: The Yale approach. Journal Of Nuclear Cardiology 2007, 14: 483-491. PMID: 17679055, DOI: 10.1016/j.nuclcard.2007.06.005.Peer-Reviewed Original Research
2006
Aperture Collimation Correction and Maximum-Likelihood Image Reconstruction for Near-Field Coded Aperture Imaging of Single Photon Emission Computerized Tomography
Mu Z, Liu YH. Aperture Collimation Correction and Maximum-Likelihood Image Reconstruction for Near-Field Coded Aperture Imaging of Single Photon Emission Computerized Tomography. IEEE Transactions On Medical Imaging 2006, 25: 701-711. PMID: 16768235, DOI: 10.1109/tmi.2006.873298.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsArtifactsData Interpretation, StatisticalFeasibility StudiesHumansImage EnhancementImage Interpretation, Computer-AssistedImaging, Three-DimensionalInformation Storage and RetrievalLikelihood FunctionsPhantoms, ImagingReproducibility of ResultsSensitivity and SpecificityTomography, Emission-Computed, Single-PhotonConceptsX-ray astronomySingle projectionCA imagesCoded Aperture ImagingMLEM reconstruction algorithmNear-field artifactsCollimation effectMaximum-likelihood image reconstructionSPECT systemParallel-hole collimatorImage reconstruction methodImage resolutionAperture imagingCollimationDeconvolution methodDual acquisitionImage reconstructionCount sensitivityImaging techniquesPhoton emissionPinholesReconstruction algorithm
2005
Clinical validation of SPECT attenuation correction using x-ray computed tomography–derived attenuation maps: Multicenter clinical trial with angiographic correlation
Masood Y, Liu Y, DePuey G, Taillefer R, Araujo LI, Allen S, Delbeke D, Anstett F, Peretz A, Zito M, Tsatkin V, Wackers FJ. Clinical validation of SPECT attenuation correction using x-ray computed tomography–derived attenuation maps: Multicenter clinical trial with angiographic correlation. Journal Of Nuclear Cardiology 2005, 12: 676-686. PMID: 16344230, DOI: 10.1016/j.nuclcard.2005.08.006.Peer-Reviewed Original ResearchNew hybrid count- and geometry-based method for quantification of left ventricular volumes and ejection fraction from ECG-gated SPECT: Methodology and validation
Liu YH, Sinusas AJ, Khaimov D, Gebuza BI, Wackers FJ. New hybrid count- and geometry-based method for quantification of left ventricular volumes and ejection fraction from ECG-gated SPECT: Methodology and validation. Journal Of Nuclear Cardiology 2005, 12: 55-65. PMID: 15682366, DOI: 10.1016/j.nuclcard.2004.09.015.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlgorithmsElectrocardiographyFemaleGated Blood-Pool ImagingHumansImage Interpretation, Computer-AssistedMaleMiddle AgedPhantoms, ImagingReproducibility of ResultsSensitivity and SpecificitySeverity of Illness IndexStroke VolumeTomography, Emission-Computed, Single-PhotonVentricular Dysfunction, LeftA New Method for SPECT Quantification of Targeted Radiotracers Uptake in the Myocardium
Li S, Dobrucki LW, Sinusas AJ, Liu YH. A New Method for SPECT Quantification of Targeted Radiotracers Uptake in the Myocardium. Lecture Notes In Computer Science 2005, 8: 684-691. PMID: 16686019, DOI: 10.1007/11566489_84.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDrug Delivery SystemsHeartImage Interpretation, Computer-AssistedMyocardiumNeovascularization, PathologicRadioisotopesRadiopharmaceuticalsRatsReperfusion InjuryReproducibility of ResultsSensitivity and SpecificityTomography, Emission-Computed, Single-PhotonVentricular Dysfunction, Left
1999
Quantification of regional myocardial wall thickening on electrocardiogram-gated SPECT imaging
Shen M, Liu Y, Sinusas A, Fetterman R, Bruni W, Drozhinin O, Zaret B, Wackers F. Quantification of regional myocardial wall thickening on electrocardiogram-gated SPECT imaging. Journal Of Nuclear Cardiology 1999, 6: 583-595. PMID: 10608585, DOI: 10.1016/s1071-3581(99)90095-8.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsComputer SimulationDiastoleElectrocardiographyHeart VentriclesHumansImage Processing, Computer-AssistedModels, CardiovascularMyocardial InfarctionObserver VariationPhantoms, ImagingPilot ProjectsRadiopharmaceuticalsReproducibility of ResultsSoftwareSystoleTechnetium Tc 99m SestamibiTomography, Emission-Computed, Single-PhotonVentricular Function, LeftVentricular RemodelingVentriculography, First-PassConceptsPrior myocardial infarctionRegional wall thickeningNormal subjectsMyocardial infarctionWall thickeningNormal wall thickeningPilot studyRegional left ventricular functionLeft ventricular functionAbnormal wall thickeningPercent count increaseECG-gated SPECT imagesSingle photon emissionSPECT imagesCardiac cycleLeft ventricular wallReproducibility of interpretationRegional left ventricular wallPrior infarctionCoronary diseaseVentricular functionValidation studyInfarct areaNormal rangeAnatomic areas