2022
Podocyte Endocytosis in Regulating the Glomerular Filtration Barrier
Tian X, Bunda P, Ishibe S. Podocyte Endocytosis in Regulating the Glomerular Filtration Barrier. Frontiers In Medicine 2022, 9: 801837. PMID: 35223901, PMCID: PMC8866310, DOI: 10.3389/fmed.2022.801837.Peer-Reviewed Original ResearchPlasma membrane componentsHuman genetic mutationsGlomerular filtration barrierEndocytosis genesEndocytic machineryFiltration barrierTransmembrane receptorsBiological functionsVesicle formationSignaling pathwaysEndocytosisMembrane componentsPodocyte functionCellular endocytosisNovel insightsProteinuric glomerular diseasesAdjacent basement membraneGenetic mutationsFunction studiesEpithelial cellsPathwayEndothelial cell layerBasement membraneImportant roleCell layer
2014
Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance
Tian X, Kim JJ, Monkley SM, Gotoh N, Nandez R, Soda K, Inoue K, Balkin DM, Hassan H, Son SH, Lee Y, Moeckel G, Calderwood DA, Holzman LB, Critchley DR, Zent R, Reiser J, Ishibe S. Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance. Journal Of Clinical Investigation 2014, 124: 1098-1113. PMID: 24531545, PMCID: PMC3934159, DOI: 10.1172/jci69778.Peer-Reviewed Original ResearchConceptsNephrotic syndromeFoot process effacementLoss of talin1Glomerular filtration barrierGlomerular injuryMurine modelProcess effacementKidney's glomerular filtration barrierFiltration barrierGlomerular basement membraneSevere proteinuriaKidney failurePharmacologic inhibitionSyndromeBarrier maintenanceCalpain activityIntegrin activationEpithelial cellsPodocytesModest reductionΒ1 integrin activationBasement membranePathogenesisInjuryCytoskeletal protein talin1