Featured Publications
Influence of Nonsyndromic Bicoronal Synostosis and Syndromic Influences on Orbit and Periorbital Malformation
Lu X, Forte AJ, Dinis J, Junn A, Alperovich M, Alonso N, Persing JA. Influence of Nonsyndromic Bicoronal Synostosis and Syndromic Influences on Orbit and Periorbital Malformation. Plastic & Reconstructive Surgery 2022, 149: 930e-942e. PMID: 35286288, DOI: 10.1097/prs.0000000000009051.Peer-Reviewed Original ResearchMeSH KeywordsAcrocephalosyndactyliaCraniofacial DysostosisCraniosynostosesHumansInfantMicrognathismOrbitSyndromeConceptsApert syndromeCrouzon syndromeBicoronal synostosisNonsyndromic bicoronal synostosisNonsyndromic casesPreoperative computed tomography scansSpine positionCLINICAL QUESTION/LEVELComputed tomography scanOrbital cavity volumeLateral orbital wallTomography scanApert patientsMaxillary retrusionPremature suture fusionMaxillary hypoplasiaSyndromePatientsCrouzon patientsOrbital wallSyndromic craniosynostosisAnteroposterior lengthVolumetric analysisSynostosisMalformationsRespective Roles of Craniosynostosis and Syndromic Influences on Cranial Fossa Development
Lu X, Forte AJ, Wilson AT, Park KE, Allam O, Alperovich M, Steinbacher DM, Alonso N, Persing JA. Respective Roles of Craniosynostosis and Syndromic Influences on Cranial Fossa Development. Plastic & Reconstructive Surgery 2021, 148: 145-156. PMID: 34181610, DOI: 10.1097/prs.0000000000008101.Peer-Reviewed Original ResearchOrbitofacial morphology changes with different suture synostoses in Crouzon syndrome
Lu X, Forte AJ, Junn A, Dinis J, Alperovich M, Alonso N, Persing JA. Orbitofacial morphology changes with different suture synostoses in Crouzon syndrome. Journal Of Cranio-Maxillofacial Surgery 2021, 50: 406-418. PMID: 35065874, DOI: 10.1016/j.jcms.2021.06.012.Peer-Reviewed Original ResearchConceptsCrouzon syndrome patientsSquamosal synostosisSyndrome patientsCT scanBicoronal synostosisCrouzon syndromeComputed tomography scanSoft tissue volumeType ISurgical interventionTomography scanNormal controlsOccipital expansionGlobe volumeCrouzon patientsSagittal synostosisPatientsAnteroposterior lengthSynostosisOrbital rimStatistical significanceTissue volumeSynostosesType IVType VGrowth patterns of the airway in Crouzon syndrome patients with different types of cranial vault suture synostosis
Lu X, Forte AJ, Wilson A, Park KE, Allam O, Alperovich M, Steinbacher DM, Tonello C, Alonso N, Persing JA. Growth patterns of the airway in Crouzon syndrome patients with different types of cranial vault suture synostosis. International Journal Of Oral And Maxillofacial Surgery 2020, 50: 924-932. PMID: 33384236, DOI: 10.1016/j.ijom.2020.11.023.Peer-Reviewed Original ResearchMeSH KeywordsCranial SuturesCraniofacial DysostosisCraniosynostosesFacial BonesHumansInfantSuturesTomography, X-Ray ComputedConceptsAirway volumeCrouzon syndrome patientsYears of ageNasal airwaySyndrome patientsCrouzon patientsPharyngeal airwayCrouzon syndromeSuture synostosisNasopharyngeal airway volumePharyngeal airway volumeNasal airway volumeType IComputed tomography scanType IIIBilateral coronal synostosisAirway compromiseRespiratory difficultyControl subjectsTomography scanAirwayPatientsPharyngeal volumeSagittal synostosisCoronal synostosisRacial disparity in orbital morphology and spatial relations in unoperated Crouzon patients
Lu X, Forte A, Fan F, Zhang Z, Teng L, Yang B, Alperovich M, Steinbacher D, Alonso N, Persing J. Racial disparity in orbital morphology and spatial relations in unoperated Crouzon patients. British Journal Of Oral And Maxillofacial Surgery 2020, 59: 579-585. PMID: 33581885, DOI: 10.1016/j.bjoms.2020.10.001.Peer-Reviewed Original ResearchSphenoid Bone Structure and Its Influence on the Cranium in Syndromic Versus Nonsyndromic Craniosynostosis.
Lu X, Forte AJ, Park KE, Allam O, Mozaffari MA, Alperovich M, Steinbacher DM, Alonso N, Persing JA. Sphenoid Bone Structure and Its Influence on the Cranium in Syndromic Versus Nonsyndromic Craniosynostosis. Journal Of Craniofacial Surgery 2020, 32: 67-72. PMID: 32868725, DOI: 10.1097/scs.0000000000006914.Peer-Reviewed Original ResearchCranial Fossa Development in Differing Subtypes of Crouzon Syndrome.
Lu X, Forte AJ, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Cranial Fossa Development in Differing Subtypes of Crouzon Syndrome. Journal Of Craniofacial Surgery 2020, 31: 673-677. PMID: 32049910, DOI: 10.1097/scs.0000000000006181.Peer-Reviewed Original ResearchClassification of Subtypes of Crouzon Syndrome Based on the Type of Vault Suture Synostosis.
Lu X, Sawh-Martinez R, Forte AJ, Wu R, Cabrejo R, Wilson A, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Classification of Subtypes of Crouzon Syndrome Based on the Type of Vault Suture Synostosis. Journal Of Craniofacial Surgery 2020, 31: 678-684. PMID: 32068731, DOI: 10.1097/scs.0000000000006173.Peer-Reviewed Original ResearchConceptsClass IIICrouzon syndromeClass IClass IISuture involvementSuture synostosisSimilar craniofacial characteristicsComputed tomography scanClassification of subtypesSurgical interventionMorphology of patientsAnatomic deformityTomography scanSurgical techniqueCT scanDifferent subtypesSagittal synostosisSyndromeClass IVPremature closureCraniofacial characteristicsSevere craniofacial malformationsCranial base lengthSynostosisDifferent pathologies
2021
Does different cranial suture synostosis influence orbit volume and morphology in Apert syndrome?
Lu X, Forte A, Alperovich M, Alonso N, Persing J. Does different cranial suture synostosis influence orbit volume and morphology in Apert syndrome? International Journal Of Oral And Maxillofacial Surgery 2021, 51: 338-346. PMID: 34400025, DOI: 10.1016/j.ijom.2021.07.019.Peer-Reviewed Original ResearchConceptsApert syndrome patientsSyndrome patientsBone volumeApert syndromeBicoronal synostosisType IType IIISuture synostosisComputed tomography scanType IIMaxillary bone volumeIndividualized surgical planningOrbital cavity volumeBilateral coronal synostosisTomography scanAnatomic basisBone malformationsSurgical planningSynostosisCoronal synostosisOrbital rimStatistical significanceOrbit volumePatientsSyndromeFacial Dysmorphology in Saethre-Chotzen Syndrome
Junn A, Dinis J, Lu X, Forte AJ, Mozaffari MA, Phillips S, Lopez J, Alonso N, Persing JA, Alperovich M. Facial Dysmorphology in Saethre-Chotzen Syndrome. Journal Of Craniofacial Surgery 2021, 32: 2660-2665. PMID: 34727468, DOI: 10.1097/scs.0000000000007910.Peer-Reviewed Original ResearchMeSH KeywordsAcrocephalosyndactyliaCephalometryCraniosynostosesForeheadHumansPlastic Surgery ProceduresConceptsSCS patientsSaethre-Chotzen syndromeMandibular prognathismNonsyndromic patientsNasal bridgePreoperative computer-tomography (CT) scanNasal boneNonsyndromic craniosynostosis patientsB point angleProminent nasal bridgeBroad nasal bridgeMann-Whitney UComputer tomography scansEyelid ptosisTomography scanMaxillary retrusionSuture pathologyNormal controlsMaxillary hypoplasiaPatientsClassic featuresCraniosynostosis patientsUnaffected controlsSyndromeClassic descriptionAberrant Morphologic Patterning of Combined Sagittal and Metopic Craniosynostosis
Dinis J, Junn A, Lu X, Lopez J, Persing J. Aberrant Morphologic Patterning of Combined Sagittal and Metopic Craniosynostosis. Journal Of Craniofacial Surgery 2021, 32: 2184-2185. PMID: 34183627, DOI: 10.1097/scs.0000000000007676.Peer-Reviewed Original ResearchCephalocranial Disproportionate Fossa Volume and Normal Skull Base Angle in Pfeiffer Syndrome.
Lu X, Forte AJ, Allam O, Park KE, Alperovich M, Steinbacher DM, Tonello C, Alonso N, Persing JA. Cephalocranial Disproportionate Fossa Volume and Normal Skull Base Angle in Pfeiffer Syndrome. Journal Of Craniofacial Surgery 2021, 32: 581-586. PMID: 33704985, DOI: 10.1097/scs.0000000000007203.Peer-Reviewed Original ResearchMeSH KeywordsAcrocephalosyndactyliaChildCranial Fossa, AnteriorCranial Fossa, PosteriorCranial SuturesCraniosynostosesHumansInfantSkullSkull BaseConceptsPfeiffer syndrome patientsMiddle cranial fossaCranial fossaSyndrome patientsFossa volumePfeiffer patientsSurgical interventionSuture synostosisPfeiffer syndromePreoperative CT scanPosterior cranial fossa volumeAnterior cranial fossaSkull base developmentSkull base angleClinical manifestationsCraniosynostosis disordersCT scanPosterior fossaNormal controlsAnatomic basisAnterior fossaPatientsSquamosal synostosisStructural abnormalitiesSubgroup comparisonsDistinguishing craniomorphometric characteristics and severity in metopic synostosis patients
Chandler L, Park K, Allam O, Mozaffari M, Khetpal S, Smetona J, Pourtaheri N, Lu X, Persing J, Alperovich M. Distinguishing craniomorphometric characteristics and severity in metopic synostosis patients. International Journal Of Oral And Maxillofacial Surgery 2021, 50: 1040-1046. PMID: 33483210, DOI: 10.1016/j.ijom.2020.11.022.Peer-Reviewed Original Research
2020
Current Controversies in Craniosynostosis Research: A Tribute to Ian Jackson
Smetona J, Junn A, Dinis J, Lopez J, Lu X, Alperovich M, Persing JA. Current Controversies in Craniosynostosis Research: A Tribute to Ian Jackson. Journal Of Craniofacial Surgery 2020, 32: 1199-1203. PMID: 33306645, DOI: 10.1097/scs.0000000000007331.Peer-Reviewed Original ResearchDistinguishing Craniomorphometric Characteristics of Unilateral Lambdoid Craniosynostosis.
Allam O, Park KE, Pourtaheri N, Mozaffari MA, Smetona J, Lu X, Ahmad M, Persing JA, Alperovich M. Distinguishing Craniomorphometric Characteristics of Unilateral Lambdoid Craniosynostosis. Journal Of Craniofacial Surgery 2020, 32: 125-129. PMID: 33156173, DOI: 10.1097/scs.0000000000007098.Peer-Reviewed Original ResearchMeSH KeywordsCranial SuturesCraniosynostosesDiagnosis, DifferentialFemaleHumansInfantMaleMastoidTomography, X-Ray ComputedConceptsUnilateral lambdoid synostosisUL patientsDeformational plagiocephalySingle-suture nonsyndromic craniosynostosisPosterior deformational plagiocephalyUnilateral lambdoid craniosynostosisDP patientsClinical findingsPathological characteristicsRare formPatientsAnterior midlineLambdoid craniosynostosisMajority maleCT imagingLambdoid synostosisNonsyndromic craniosynostosisReliable indicatorSignificant differencesLambdoid sutureSide earCraniosynostosisScansEarPatient scansSMAD6 Genotype Predicts Neurodevelopment in Nonsyndromic Craniosynostosis.
Wu RT, Timberlake AT, Abraham PF, Gabrick KS, Lu X, Peck CJ, Sawh-Martinez RF, Steinbacher DM, Alperovich MA, Persing JA. SMAD6 Genotype Predicts Neurodevelopment in Nonsyndromic Craniosynostosis. Plastic & Reconstructive Surgery 2020, 145: 117e-125e. PMID: 31592950, DOI: 10.1097/prs.0000000000006319.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesChildChild BehaviorChild DevelopmentChild, PreschoolCraniosynostosesCraniotomyDevelopmental DisabilitiesDouble-Blind MethodFemaleFollow-Up StudiesHumansInfantIntelligence TestsLoss of Function MutationMalePlastic Surgery ProceduresProspective StudiesSkullSmad6 ProteinTreatment Outcome
2019
The Endocranial Bifrontal Angle: A Longitudinal Evaluation in Two Patients With Metopic Synostosis.
Cabrejo R, Lu X, Persing J. The Endocranial Bifrontal Angle: A Longitudinal Evaluation in Two Patients With Metopic Synostosis. Journal Of Craniofacial Surgery 2019, 30: 1644-1646. PMID: 30939543, DOI: 10.1097/scs.0000000000005358.Peer-Reviewed Original ResearchMeSH KeywordsCraniosynostosesDisease ProgressionHumansInfantInfant, NewbornMaleTomography, X-Ray ComputedConceptsSmaller head circumferenceEndocranial bifrontal angleHead circumferenceMetopic craniosynostosisNeurological sequelaeNeurological deficitsSurgical treatmentSevere formPatientsSevere trigonocephalyLongitudinal evaluationMetopic sutureMetopic synostosisTomography imagingSkull deformityCraniosynostosisCircumferenceTrigonocephalyFrontal regionsYoung childrenSkull bonesSubsequent evaluationChildrenSequelaeDeformityWhat Is the Skull Structure Influence of Squamosal Suture Synostosis in Nonsyndromic and Syndromic Crouzon Craniosynostosis?
Lu X, Chen G, Forte AJ, Cabrejo R, Singh A, Kyle G, Steinbacher DM, Alperovich M, Alonso N, Persing JA. What Is the Skull Structure Influence of Squamosal Suture Synostosis in Nonsyndromic and Syndromic Crouzon Craniosynostosis? Journal Of Craniofacial Surgery 2019, 30: 1671-1675. PMID: 30950948, DOI: 10.1097/scs.0000000000005396.Peer-Reviewed Original ResearchConceptsMiddle cranial fossaAnterior cranial fossaCranial fossaPosterior cranial fossaSquamosal synostosisFossa volumeCrouzon syndromeSquamosal suture synostosisComputed tomography scanCranial volumeNonsyndromic craniosynostosis patientsVolume reductionSevere volume reductionTomography scanNormal controlsMorphologic effectsCraniosynostosis patientsFossaPremature closureSyndromic conditionsSuture synostosisSyndromic synostosisFrankfort horizontal planeSynostosisThree-dimensional cephalometry