Featured Publications
Influence of Nonsyndromic Bicoronal Synostosis and Syndromic Influences on Orbit and Periorbital Malformation
Lu X, Forte AJ, Dinis J, Junn A, Alperovich M, Alonso N, Persing JA. Influence of Nonsyndromic Bicoronal Synostosis and Syndromic Influences on Orbit and Periorbital Malformation. Plastic & Reconstructive Surgery 2022, 149: 930e-942e. PMID: 35286288, DOI: 10.1097/prs.0000000000009051.Peer-Reviewed Original ResearchConceptsApert syndromeCrouzon syndromeBicoronal synostosisNonsyndromic bicoronal synostosisNonsyndromic casesPreoperative computed tomography scansSpine positionCLINICAL QUESTION/LEVELComputed tomography scanOrbital cavity volumeLateral orbital wallTomography scanApert patientsMaxillary retrusionPremature suture fusionMaxillary hypoplasiaSyndromePatientsCrouzon patientsOrbital wallSyndromic craniosynostosisAnteroposterior lengthVolumetric analysisSynostosisMalformationsMorphological Basis for Airway Surgical Intervention in Apert Syndrome
Lu X, Forte AJ, Park KE, Allam O, Alperovich M, Steinbacher DM, Tonello C, Alonso N, Persing JA. Morphological Basis for Airway Surgical Intervention in Apert Syndrome. Annals Of Plastic Surgery 2020, 87: 59-64. PMID: 34133365, DOI: 10.1097/sap.0000000000002601.Peer-Reviewed Original ResearchConceptsApert syndrome patientsPharyngeal airway volumeComputed tomography scanSyndrome patientsApert syndromeAirway volumeSurgical interventionTomography scanNasal cavityPreoperative computed tomography scansAirway volume changesAge-related subgroupsYears of ageMonths of agePosition of maxillaGrowth of mandibleAirway compromiseNasopharyngeal airwayPharyngeal airwayNasal airwayIntergonial widthSyndromeAirwayPatientsAnteroposterior lengthAirway Development Relevant to Cranial Vault Suture Synostosis Subtype in Apert Syndrome
Lu X, Forte A, Park K, Allam O, Steinbacher D, Alperovich M, Passos-Bueno M, Tonello C, Alonso N, Persing J. Airway Development Relevant to Cranial Vault Suture Synostosis Subtype in Apert Syndrome. FACE 2020, 1: 89-96. DOI: 10.1177/2732501620973030.Peer-Reviewed Original ResearchPharyngeal airwayAirway volumeNasal airwayApert patientsCT scanNasal cavityCross-sectional areaApert syndromeSuture synostosisNasopharyngeal airway volumePharyngeal airway volumeAirway volume changesDecreased cross-sectional areaType IIIBilateral coronal synostosisType IIAirway developmentSyndrome subtypesCranial base angulationAirwayEstablished classification systemPatientsSurgical planningSectional areaCoronal synostosisSphenoid Bone Structure and Its Influence on the Cranium in Syndromic Versus Nonsyndromic Craniosynostosis.
Lu X, Forte AJ, Park KE, Allam O, Mozaffari MA, Alperovich M, Steinbacher DM, Alonso N, Persing JA. Sphenoid Bone Structure and Its Influence on the Cranium in Syndromic Versus Nonsyndromic Craniosynostosis. Journal Of Craniofacial Surgery 2020, 32: 67-72. PMID: 32868725, DOI: 10.1097/scs.0000000000006914.Peer-Reviewed Original Research
2021
Does different cranial suture synostosis influence orbit volume and morphology in Apert syndrome?
Lu X, Forte A, Alperovich M, Alonso N, Persing J. Does different cranial suture synostosis influence orbit volume and morphology in Apert syndrome? International Journal Of Oral And Maxillofacial Surgery 2021, 51: 338-346. PMID: 34400025, DOI: 10.1016/j.ijom.2021.07.019.Peer-Reviewed Original ResearchConceptsApert syndrome patientsSyndrome patientsBone volumeApert syndromeBicoronal synostosisType IType IIISuture synostosisComputed tomography scanType IIMaxillary bone volumeIndividualized surgical planningOrbital cavity volumeBilateral coronal synostosisTomography scanAnatomic basisBone malformationsSurgical planningSynostosisCoronal synostosisOrbital rimStatistical significanceOrbit volumePatientsSyndrome
2020
Cranial Fossa Volume and Morphology Development in Apert Syndrome.
Lu X, Forte AJ, Wilson A, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Cranial Fossa Volume and Morphology Development in Apert Syndrome. Plastic & Reconstructive Surgery 2020, 145: 790e-802e. PMID: 32221226, DOI: 10.1097/prs.0000000000006679.Peer-Reviewed Original Research
2019
Airway Analysis in Apert Syndrome.
Forte AJ, Lu X, Hashim PW, Steinbacher DM, Alperovich M, Persing JA, Alonso N. Airway Analysis in Apert Syndrome. Plastic & Reconstructive Surgery 2019, 144: 704-709. PMID: 31461034, DOI: 10.1097/prs.0000000000005937.Peer-Reviewed Original ResearchConceptsPosterior nasal spineApert syndromeNasal spineTomographic scanPharyngeal airway volumeRespiratory insufficiencyAirway compromiseAirway volumeAirway spaceRespiratory impairmentClinical managementAirway analysisPosterior airwayNasal cavityDisease comorbiditiesPatientsSyndromeSkull baseNasal measurementsSpine distanceStatistical significanceMidfacial deformitiesSpineAirwayPharyngeal regionClassification of Subtypes of Apert Syndrome, Based on the Type of Vault Suture Synostosis
Lu X, Sawh-Martinez R, Forte A, Wu R, Cabrejo R, Wilson A, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Classification of Subtypes of Apert Syndrome, Based on the Type of Vault Suture Synostosis. Plastic & Reconstructive Surgery Global Open 2019, 7: e2158. PMID: 31044122, PMCID: PMC6467634, DOI: 10.1097/gox.0000000000002158.Peer-Reviewed Original ResearchApert syndromeCranial base angulationClass IClass IICommon subtypeCoronal synostosisObstructive sleep apneaCranial baseApert syndrome patientsBilateral coronal synostosisClassification of subtypesUnilateral lambdoid synostosisUnilateral coronal synostosisAirway compromiseSleep apneaAnatomic deformityTreatment choiceSyndrome patientsPosterior aspectOropharyngeal spaceCT scanCranial base angleCleft palateClass IIISyndromeTemporal Evaluation of Craniofacial Relationships in Apert Syndrome
Lu X, Forte AJ, Sawh-Martinez R, Wu R, Cabrejo R, Gabrick K, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Temporal Evaluation of Craniofacial Relationships in Apert Syndrome. Journal Of Craniofacial Surgery 2019, 30: 317-325. PMID: 30358751, DOI: 10.1097/scs.0000000000004836.Peer-Reviewed Original ResearchConceptsYears of ageApert syndromeNasal spineComputed tomography scanMaxillary planeAnterior nasal spineMonths of ageApert syndrome patientsPosterior nasal spineSella-nasion planeTomography scanSyndrome patientsAge subgroupsAnatomic relationshipsSyndromeFacial deformityAngulation changeFrankfort horizontal planeCranial base lengthMonthsIntracellular regulatory mechanismsCraniofacial malformationsAgeDeformityMaterialize software
2018
Normal angulation of skull base in Apert syndrome
Lu X, Forte AJ, Sawh-Martinez R, Wu R, Cabrejo R, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Normal angulation of skull base in Apert syndrome. Journal Of Cranio-Maxillofacial Surgery 2018, 46: 2042-2051. PMID: 30391086, DOI: 10.1016/j.jcms.2018.09.026.Peer-Reviewed Original ResearchConceptsAnterior cranial baseApert syndromeCranial base lengthSkull baseSevere craniofacial deformitiesPosterior cranial base lengthYears of ageMonths of ageUnoperated patientsCT scanAnterior cranial base lengthCranial base angleLate infancySyndromeAge rangeCraniofacial deformitiesCranial baseDeformityAdditive effectSkull vaultMonthsAngulationSignificant changesAgeBase length