2024
Genome-Wide Association Study of Acute Lymphoblastic Leukemia in Hispanic/Latino Children Identifies a Putatively Novel Risk Locus at Chromosome 5q31.1
Liu T, Langie J, Yang W, Morimoto L, Ma X, Metayer C, Lupo P, Scheurer M, Yang J, Wiemels J, Chiang C, de Smith A. Genome-Wide Association Study of Acute Lymphoblastic Leukemia in Hispanic/Latino Children Identifies a Putatively Novel Risk Locus at Chromosome 5q31.1. Blood 2024, 144: 317. DOI: 10.1182/blood-2024-208796.Peer-Reviewed Original ResearchGenome-wide association studiesMulti-Ethnic Study of AtherosclerosisCalifornia Childhood Leukemia StudySingle nucleotide polymorphismsMinor allele frequencyRisk lociHispanic/Latino individualsHispanic/Latino populationFixed-effect inverse-variance weighted meta-analysisMeta-analysis genome-wide association studyInverse-variance weighted meta-analysisHispanic Community Health Study/Study of LatinosHispanic Community Health Study/StudyHigher risk of acute lymphoblastic leukemiaHigher risk allele frequencyOdds of acute lymphoblastic leukemiaGenome-wide significant association signalsImputation quality scoreSNPs' minor allele frequencyRisk of acute lymphoblastic leukemiaGenome-wide significance thresholdAcute lymphoblastic leukemia riskEuropean ancestry populationsGenome-wide imputationMulti-Ethnic Study
2019
The Genome-Wide Impact of Trisomy 21 on DNA Methylation and Its Implications for Hematologic Malignancies
Wiemels J, Muskens I, Li S, Pandey P, Roy R, Hansen H, Siegmund K, Mueller B, Ma X, Metayer C, de Smith A. The Genome-Wide Impact of Trisomy 21 on DNA Methylation and Its Implications for Hematologic Malignancies. Blood 2019, 134: 2510. DOI: 10.1182/blood-2019-131455.Peer-Reviewed Original ResearchTransient abnormal myelopoiesisNon-DS subjectsDS neonatesDown syndromeTrisomy 21Hematopoietic stem cellsBlood cell proportionsT cellsHigher CD8 T cellsCell proportionEpigenome-wide association studiesMean beta valueNon-DS controlsCD8 T cellsCD4 T cellsLow B cellsAcute lymphoblastic leukemiaAcute megakaryoblastic leukemiaMulti-Ethnic StudyNeonatal DNA methylationEthnicity-stratified analysisSignificant DMRsIllumina Infinium MethylationEPIC arrayChromosome 21Non-Latino whites