Genome-Wide Association Study of Acute Lymphoblastic Leukemia in Hispanic/Latino Children Identifies a Putatively Novel Risk Locus at Chromosome 5q31.1
Liu T, Langie J, Yang W, Morimoto L, Ma X, Metayer C, Lupo P, Scheurer M, Yang J, Wiemels J, Chiang C, de Smith A. Genome-Wide Association Study of Acute Lymphoblastic Leukemia in Hispanic/Latino Children Identifies a Putatively Novel Risk Locus at Chromosome 5q31.1. Blood 2024, 144: 317. DOI: 10.1182/blood-2024-208796.Peer-Reviewed Original ResearchGenome-wide association studiesMulti-Ethnic Study of AtherosclerosisCalifornia Childhood Leukemia StudySingle nucleotide polymorphismsMinor allele frequencyRisk lociHispanic/Latino individualsHispanic/Latino populationFixed-effect inverse-variance weighted meta-analysisMeta-analysis genome-wide association studyInverse-variance weighted meta-analysisHispanic Community Health Study/Study of LatinosHispanic Community Health Study/StudyHigher risk of acute lymphoblastic leukemiaHigher risk allele frequencyOdds of acute lymphoblastic leukemiaGenome-wide significant association signalsImputation quality scoreSNPs' minor allele frequencyRisk of acute lymphoblastic leukemiaGenome-wide significance thresholdAcute lymphoblastic leukemia riskEuropean ancestry populationsGenome-wide imputationMulti-Ethnic StudyA noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children
de Smith A, Wahlster L, Jeon S, Kachuri L, Black S, Langie J, Cato L, Nakatsuka N, Chan T, Xia G, Mazumder S, Yang W, Gazal S, Eng C, Hu D, Burchard E, Ziv E, Metayer C, Mancuso N, Yang J, Ma X, Wiemels J, Yu F, Chiang C, Sankaran V. A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children. Cell Genomics 2024, 4: 100526. PMID: 38537633, PMCID: PMC11019360, DOI: 10.1016/j.xgen.2024.100526.Peer-Reviewed Original ResearchHispanic/Latino childrenNon-Hispanic White individualsHigher risk of acute lymphoblastic leukemiaRisk of acute lymphoblastic leukemiaNoncoding regulatory variantsFine-mapping analysisAcute lymphoblastic leukemia riskAcute lymphoblastic leukemiaEvidence of selectionIndigenous American ancestryReduced enhancer activityRisk allele frequenciesIncreased ALL riskRegulatory variantsHispanic/Latino individualsPro-B cellsHispanic/Latino populationRacial/ethnic groupsDownstream enhancerGenetic basisLeukemia riskWhite individualsAllele frequenciesAmerican ancestryALL risk