2022
miR-130b/301b Is a Negative Regulator of Beige Adipogenesis and Energy Metabolism In Vitro and In Vivo.
Luo W, Kim Y, Jensen M, Herlea-Pana O, Wang W, Rudolph M, Friedman J, Chernausek S, Jiang S. miR-130b/301b Is a Negative Regulator of Beige Adipogenesis and Energy Metabolism In Vitro and In Vivo. Diabetes 2022, 71: 2360-2371. PMID: 36001751, PMCID: PMC9630090, DOI: 10.2337/db22-0205.Peer-Reviewed Original ResearchConceptsBeige adipogenesisMiR-301bMiR-130bPeroxisome proliferator-activated receptor γ coactivator 1αProliferator-activated receptor γ coactivator 1αImproved glucose toleranceReceptor γ coactivator 1αLess weight gainPotential therapeutic targetCold-induced energy expenditureΓ coactivator 1αMitochondrial biogenesisMetabolic complicationsVisceral adiposityGlucose toleranceThermogenic brownCounteract obesityMetabolic disordersTherapeutic targetAdipose tissueBeige phenotypeMetabolic diseasesAdipose progenitor cellsBeige adipocytesCoactivator 1α
2009
Identification of exopolysaccharide‐deficient mutants of Mycoplasma pulmonis
Daubenspeck J, Bolland J, Luo W, Simmons W, Dybvig K. Identification of exopolysaccharide‐deficient mutants of Mycoplasma pulmonis. Molecular Microbiology 2009, 72: 1235-1245. PMID: 19432800, PMCID: PMC2752295, DOI: 10.1111/j.1365-2958.2009.06720.x.Peer-Reviewed Original ResearchConceptsOpen reading frameExopolysaccharide-deficient mutantsSynthesis of exopolysaccharidesTerminal beta-linked galactose residuesA549 lung cell lineHeterodimeric pairTransposon librarySecond exopolysaccharideReading frameMutantsPhenotypic analysisLung cell linesDecreased associationN-acetylglucosamineCell linesExopolysaccharideCapsular exopolysaccharideLectin affinity chromatographyGalactose residuesComplex carbohydratesNew pathwayPermeasesMouse lungMollicutesTransposon