2022
17α-estradiol, a lifespan-extending compound, attenuates liver fibrosis by modulating collagen turnover rates in male mice
Ali Mondal S, Sathiaseelan R, Mann S, Kamal M, Luo W, Saccon T, Isola J, Peelor F, Li T, Freeman W, Miller B, Stout M. 17α-estradiol, a lifespan-extending compound, attenuates liver fibrosis by modulating collagen turnover rates in male mice. AJP Endocrinology And Metabolism 2022, 324: e120-e134. PMID: 36516471, PMCID: PMC9902223, DOI: 10.1152/ajpendo.00256.2022.Peer-Reviewed Original ResearchConceptsLiver fibrosisMale miceCombination hormone replacement therapyMatrix metalloproteinase-2 activityHepatic stellate cell activationChronic liver diseaseHormone replacement therapySubset of womenMetalloproteinase-2 activityStellate cell activationGrowth factor-β1Proinflammatory macrophage activationFibrotic burdenCollagen synthesis ratesChronic treatmentLiver diseaseReplacement therapyCytokine expressionMacrophage contentImmune cellsTGF-β1Estrogen signalingHSC activationFactor-β1Macrophage activation
2020
Role of miR‐130b/301b cluster in macrophage polarization and obesity
Jiang S, McBride A, Luo W, Chernausek S. Role of miR‐130b/301b cluster in macrophage polarization and obesity. The FASEB Journal 2020, 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.09682.Peer-Reviewed Original ResearchDevelopment of obesityMacrophage polarizationKnockout miceMacrophage M1/M2 polarizationM1/M2 polarizationPro-inflammatory activationWhole-body energy expenditureHigh-fat dietEnergy expenditureAlternative macrophage activationWild-type miceWhite adipose tissueBody energy expenditureMacrophage activation statusBone marrow macrophagesPresent studyFat dietIL-4M2 polarizationType miceAlternative activationMacrophage activationAdipose tissueMetabolic diseasesActivation status