2020
Gastrointestinal Injury Related to Antiangiogenesis Cancer Therapy
Tang T, Abu-Sbeih H, Ma W, Lu Y, Luo W, Foo W, Richards D, Halperin D, Ge P, Wang Y. Gastrointestinal Injury Related to Antiangiogenesis Cancer Therapy. Clinical Colorectal Cancer 2020, 19: e117-e123. PMID: 32284253, DOI: 10.1016/j.clcc.2020.03.002.Peer-Reviewed Original ResearchConceptsAbnormal endoscopic findingsAntiangiogenesis cancer therapyIntensive care unitAntiangiogenesis therapyACD symptomsAntimotility agentsEndoscopic findingsColonic perforationCare unitTertiary care cancer centerActive histologic inflammationRare adverse eventsCancer therapyEnterocolitis symptomsHistologic inflammationNonulcerative inflammationUnderlying malignancyGastrointestinal injuryGastrointestinal toxicityMucosal ulcerationUnderwent endoscopyAdverse eventsMedian durationMost patientsEndoscopic evaluation
2019
Vedolizumab Achieved Clinical and Histologic Remission in a Patient with Lung Cancer Who Had a Steroid-Refractory Upper Gastrointestinal Injury Due to Nivolumab Treatment
Tran C, Abu-Sbeih H, Luo W, Lu Y, Wang Y. Vedolizumab Achieved Clinical and Histologic Remission in a Patient with Lung Cancer Who Had a Steroid-Refractory Upper Gastrointestinal Injury Due to Nivolumab Treatment. Journal Of Immunotherapy And Precision Oncology 2019, 2: 40-45. DOI: 10.4103/jipo.jipo_18_18.Peer-Reviewed Original ResearchImmune checkpoint inhibitorsLung cancerSteroid courseAdverse eventsAbstract Immune checkpoint inhibitorsUpper GI adverse eventsSignificant anti-tumor effectGI adverse eventsProgressive lung cancerUpper gastrointestinal injuryUpper GI toxicityAnti-tumor effectsNovel therapeutic classResolution of inflammationGI-irAEsHistologic remissionHistological remissionNivolumab treatmentVedolizumab treatmentCheckpoint inhibitorsClinical remissionGastrointestinal injuryGI toxicityPrednisone taperSevere nausea