2022
Calcifying nested stromal-epithelial tumor of the liver with recurrence in a transplanted liver – A clinical report with literature review
Kamal M, Atwi D, Gatalica Z, Luo W. Calcifying nested stromal-epithelial tumor of the liver with recurrence in a transplanted liver – A clinical report with literature review. Human Pathology Reports 2022, 28: 300620. DOI: 10.1016/j.hpr.2022.300620.Peer-Reviewed Original ResearchStromal-epithelial tumorAggressive clinical courseSmall blue cellsTERT promoter mutationsRare liver neoplasmLiver transplantationClinical courseFemale predominanceLiver failureTransplanted liverRare tumorRecurrence 3Unknown histogenesisImmunohistochemical spectrumLiver neoplasmsDiffuse positivityClinical reportsTumorsBlue cellsYoung adultsCNSETPromoter mutationsMolecular featuresPIK3CAPathologic mutations
2021
NUTM1-Rearranged Neoplasms—A Heterogeneous Group of Primitive Tumors with Expanding Spectrum of Histology and Molecular Alterations—An Updated Review
Luo W, Stevens T, Stafford P, Miettinen M, Gatalica Z, Vranic S. NUTM1-Rearranged Neoplasms—A Heterogeneous Group of Primitive Tumors with Expanding Spectrum of Histology and Molecular Alterations—An Updated Review. Current Oncology 2021, 28: 4485-4503. PMID: 34898574, PMCID: PMC8628659, DOI: 10.3390/curroncol28060381.Peer-Reviewed Original ResearchConceptsGenome-wide histone modificationsPost-meiotic spermatidsExpression of oncogenesTumor suppressor geneTranscription regulationHistone modificationsBromodomain proteinsNuclear proteinsRNA sequencingFusion proteinProtein productsSuppressor geneFusion partnerGenesSitu hybridizationDifferent clinical coursesProteinSkin adnexal tumorsPrimitive morphologyOncogenic driversInhibitor therapyClinical courseMolecular alterationsPrimitive tumorHematologic malignancies
2020
Solitary Fibrous Tumor of Pancreas With Unusual Features: A Case Report
Afzal A, Maldonado-Vital M, Khan S, Farooque U, Luo W. Solitary Fibrous Tumor of Pancreas With Unusual Features: A Case Report. Cureus 2020, 12: e10833. PMID: 33173639, PMCID: PMC7647364, DOI: 10.7759/cureus.10833.Peer-Reviewed Original ResearchPancreatic solitary fibrous tumorSolitary fibrous tumorGastrointestinal stromal tumorsFibrous tumorDiagnosis of SFTCommon neuroendocrine tumorMalignant clinical courseCluster of differentiationPotential diagnostic pitfallMajority of SFTsClinical courseBiopsied specimensStromal tumorsImmunohistochemical featuresVascular tumorsCase reportNeuroendocrine tumorsDiagnostic challengeDedifferentiated liposarcomaPathological spectrumAnatomic sitesDiagnostic pitfallsFocal positivityHypercellular areasAtypical features
2019
Gastroesophageal junction Paneth cell carcinoma with extensive cystic and secretory features – case report and literature review
Luo W, Hofstetter W, Tan D. Gastroesophageal junction Paneth cell carcinoma with extensive cystic and secretory features – case report and literature review. Diagnostic Pathology 2019, 14: 1. PMID: 30621725, PMCID: PMC6323739, DOI: 10.1186/s13000-018-0775-z.Peer-Reviewed Original ResearchConceptsNeoplastic Paneth cellsGastroesophageal junctionCell carcinomaPaneth cellsImmunohistochemical stainsProton pump inhibitor therapySubsequent endoscopic mucosal resectionHER2/neu statusBeta-catenin pathwayUpper gastrointestinal bleedingDiagnosis of adenocarcinomaEndoscopic mucosal resectionHER2/neuPeculiar histologic featuresDistinct staining patternsGastrointestinal bleedingCase presentationAInhibitor therapyClinical courseMucosal resectionHistologic featuresBarrett's esophagusEmergency roomTypical adenocarcinomaSecretory changes