2023
Evaluation of Birth Weight and Neurodevelopmental Conditions Among Monozygotic and Dizygotic Twins
Isaksson J, Ruchkin V, Ljungström T, Bölte S. Evaluation of Birth Weight and Neurodevelopmental Conditions Among Monozygotic and Dizygotic Twins. JAMA Network Open 2023, 6: e2321165. PMID: 37389871, PMCID: PMC10314302, DOI: 10.1001/jamanetworkopen.2023.21165.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderLow birth weightBirth weightHigh birth weightLower oddsNeurodevelopmental conditionsIntellectual disabilityFetal growth restrictionCase-control studyMonozygotic twinsDizygotic twinsTwin pairsMedian ageGrowth restrictionMAIN OUTCOMEGenetic predispositionEarly identificationCo-twin studyMonozygotic pairsDiagnostic assessmentHyperactivity disorderParticipant visitsGenetic riskADHD diagnosisDizygotic pairs
2022
Nonshared environmental factors in the aetiology of autism and other neurodevelopmental conditions: a monozygotic co-twin control study
Isaksson J, Ruchkin V, Aho N, Lundin Remnélius K, Marschik P, Bölte S. Nonshared environmental factors in the aetiology of autism and other neurodevelopmental conditions: a monozygotic co-twin control study. Molecular Autism 2022, 13: 8. PMID: 35183250, PMCID: PMC8858556, DOI: 10.1186/s13229-022-00487-5.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderAutism spectrum disorderNeurodevelopmental conditionsCo-twin designHyperactivity disorderSpectrum disorderCo-twin control studyEarly environmental riskLower IQAutismEtiology of autismIntellectual disabilityPrevious researchEarly interventionEarly childhoodConclusionsThe findingsPostnatal riskEquation modelMonozygotic co‐twin control studyBackgroundA significant proportionRisk loadSeparate risk factorsTwin pairsTargeted preventionWeight discordance
2019
Attention deficit/hyperactivity disorder and future expectations in Russian adolescents
Stickley A, Koposov R, Kamio Y, Takahashi H, Koyanagi A, Inoue Y, Yazawa A, Ruchkin V. Attention deficit/hyperactivity disorder and future expectations in Russian adolescents. ADHD Attention Deficit And Hyperactivity Disorders 2019, 11: 279-287. PMID: 30852726, DOI: 10.1007/s12402-019-00292-w.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderDeficit/hyperactivity disorderNegative future expectationsADHD statusHyperactivity disorderRussian adolescentsTeacher-reported ADHD symptomsFuture expectationsDifferent life domainsSchool-based sampleADHD symptomsRisky health behaviorsEducational expectationsLife domainsAdolescentsFuture outcomesCurrent studyAdolescenceHealth behaviorsExpectationsDisordersRegression analysisResearch gapResearchADHD and depressive symptoms in adolescents: the role of community violence exposure
Stickley A, Koposov R, Koyanagi A, Inoue Y, Ruchkin V. ADHD and depressive symptoms in adolescents: the role of community violence exposure. Social Psychiatry And Psychiatric Epidemiology 2019, 54: 683-691. PMID: 30706080, DOI: 10.1007/s00127-019-01662-5.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderDepressive symptomsCommunity violence exposureADHD symptomsViolence exposureCommunity violenceEpidemiologic Studies Depression ScaleEarly therapeutic interventionCo-occurring depressionLogistic regression analysisMultivariable analysisUnivariable analysisTherapeutic interventionsSymptomsVictims of violenceHyperactivity disorderDepressionNon-ADHD adolescentsHealth assessmentRegression analysisAdolescentsExposureOddsCurrent studyAssociation
2017
Attention-deficit/hyperactivity disorder and physical multimorbidity: A population-based study
Stickley A, Koyanagi A, Takahashi H, Ruchkin V, Inoue Y, Kamio Y. Attention-deficit/hyperactivity disorder and physical multimorbidity: A population-based study. European Psychiatry 2017, 45: 227-234. PMID: 28957792, DOI: 10.1016/j.eurpsy.2017.07.010.Peer-Reviewed Original ResearchConceptsPossible attention-deficit/hyperactivity disorderAttention-deficit/hyperactivity disorderHyperactivity disorderAdult attention-deficit/hyperactivity disorderPhysical multimorbidityStressful life eventsPhysical diseaseADHD symptomsPhysical health conditionsSignificant mediatorAdult Psychiatric Morbidity Survey 2007Life eventsMediation analysisPopulation-based studyMultivariable logistic regressionPoor health outcomesTimes higher oddsEnglish general populationLittle researchDoctor/Higher oddsGeneral populationMultimorbidityHealth outcomesHealth professionals
2010
Variation in the catechol-O-methyltransferase Val158Met polymorphism associated with conduct disorder and ADHD symptoms, among adolescent male delinquents
DeYoung CG, Getchell M, Koposov RA, Yrigollen CM, Haeffel GJ, Klinteberg B, Oreland L, Ruchkin VV, Pakstis AJ, Grigorenko EL. Variation in the catechol-O-methyltransferase Val158Met polymorphism associated with conduct disorder and ADHD symptoms, among adolescent male delinquents. Psychiatric Genetics 2010, 20: 20-24. PMID: 19997043, PMCID: PMC2895253, DOI: 10.1097/ypg.0b013e32833511e4.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderCatechol-O-methyltransferase (COMT) geneConduct disorderADHD symptomsHigh-risk populationCatechol-O-methyltransferase (COMT) Val158Met polymorphismCOMT geneDeficit/hyperactivity disorderConduct disorder diagnosisBehavior problemsSymptomsVal alleleMet alleleDisorder diagnosisHyperactivity disorderVal158Met polymorphismDisordersAntisocial behavior