2024
Anticoagulation Therapy for Venous Thromboembolism in the Pediatric Population: A Systematic Review and Meta-Analysis
Azzam M, Kawtharany H, Monagle P, Bercovitz R, Hamarsha Q, Alkhader A, Abou Zeid H, Mansour R, Patel P, Tabak C, Baghdadi S, Betensky M, Bhat R, Biss T, Branchford B, Brandao L, Chan A, Faustino E, Jaffray J, Jones S, Kerlin B, Kucine N, Kumar R, Male C, Pelland-Marcotte M, Raffini L, Raulji C, Sartain S, Takemoto C, Tarango C, Van Ommen H, Velez-Yanguas M, Vesely S, Wiernikowski J, Williams S, Wilson H, Woods G, Zia A, Mustafa R. Anticoagulation Therapy for Venous Thromboembolism in the Pediatric Population: A Systematic Review and Meta-Analysis. Blood 2024, 144: 1257-1257. DOI: 10.1182/blood-2024-212150.Peer-Reviewed Original ResearchRisk of biasCertainty of evidenceVenous thromboembolismPediatric patientsThrombus resolutionAll-cause mortalityThrombus recurrenceAC therapyAnticoagulant therapyAbsolute effectEvents of all-cause mortalityPediatric populationSystematic reviewNon-randomized Studies of InterventionsManagement of venous thromboembolismMeta-analysisStudies of interventionsConcerns related to riskNon-randomized observational studyNon-randomized studiesRecommendations AssessmentThrombus progressionBleeding eventsBleeding riskPortal hypertensionThrombolytic Therapy for Venous Thromboembolism in the Pediatric Population: A Systematic Review and Meta-Analysis
Kawtharany H, Azzam M, Monagle P, Bercovitz R, Alkhader A, Hamarsha Q, Zeid H, Mansour R, Tabak C, Patel P, Baghdadi S, Betensky M, Bhat R, Biss T, Branchford B, Brandao L, Chan A, Faustino E, Jaffray J, Jones S, Kerlin B, Kucine N, Kumar R, Male C, Pelland-Marcotte M, Raffini L, Raulji C, Sartain S, Takemoto C, Tarango C, Van Ommen H, Velez M, Vesely S, Wiernikowski J, Williams S, Wilson H, Woods G, Zia A, Mustafa R. Thrombolytic Therapy for Venous Thromboembolism in the Pediatric Population: A Systematic Review and Meta-Analysis. Blood 2024, 144: 2633. DOI: 10.1182/blood-2024-212166.Peer-Reviewed Original ResearchRate of thrombus resolutionAbsolute riskRisk of biasCertainty of evidenceMassive PEThrombolytic therapyPediatric patientsOutcome of thrombolysisAC groupPulmonary embolismSystematic reviewThrombus resolutionCovidence systematic review softwareRisk of thrombosis recurrenceThrombolysis groupMeta-analysisConcerns related to riskSystematic review softwareSubmassive pulmonary embolismChronic pulmonary hypertensionManagement of VTERestoring venous patencyRisk of progressionCochrane Central Register of Controlled TrialsCentral Register of Controlled Trials
2021
Performance of an Electronic Decision Support System as a Therapeutic Intervention During a Multicenter PICU Clinical Trial Heart and Lung Failure-Pediatric Insulin Titration Trial (HALF-PINT)
Hirshberg E, Alexander J, Asaro L, Coughlin-Wells K, Steil G, Spear D, Stone C, Nadkarni V, Agus M, Investigators H, Agus M, Wypij D, Asaro L, Nadkarni V, Srinivasan V, Biagas K, Mourani P, Chima R, Thomas N, Li S, Pinto A, Newth C, Hassinger A, Bysani K, Rehder K, Faustino E, Kandil S, Hirshberg E, Wintergerst K, Schwarz A, Bagdure D, Marsillio L, Cvijanovich N, Pham N, Quasney M, Flori H, Federman M, Nett S, Pinto N, Viteri S, Schneider J, Medar S, Sapru A, McQuillen P, Babbitt C, Lin J, Jouvet P, Yanay O, Allen C, Luckett P, Fackler J, Rozen T. Performance of an Electronic Decision Support System as a Therapeutic Intervention During a Multicenter PICU Clinical Trial Heart and Lung Failure-Pediatric Insulin Titration Trial (HALF-PINT). CHEST Journal 2021, 160: 919-928. PMID: 33932465, PMCID: PMC8449010, DOI: 10.1016/j.chest.2021.04.049.Peer-Reviewed Original ResearchConceptsLung Failure-Pediatric INsulin Titration trialBlood glucose targetsCritical care trialsManagement of hyperglycemiaTitration trialCare trialsGlucose targetsCDS toolElectronic clinical decision support systemLow complianceBlood glucose metricsIll pediatric patientsObservational retrospective studyElectronic decision support systemClinical decision support systemInotropic supportPediatric patientsPatient factorsRetrospective studyClinician factorsIll childrenGlucose metricsPatientsTherapeutic interventionsStudy designAssociation of Race and Ethnicity with Sedation Management in Pediatric Intensive Care.
Natale J, Asaro L, Joseph J, Ulysse C, Ascenzi J, Bowens C, Wypij D, Curley M, Curley M, Wypij D, Allen G, Angus D, Asaro L, Ascenzi J, Bateman S, Borasino S, Bowens C, Bysani G, Cheifetz I, Cowl A, Dodson B, Faustino E, Fineman L, Flori H, Franck L, Gedeit R, Grant M, Harabin A, Haskins-Kiefer C, Hertzog J, Hutchins L, Kirby A, Lebet R, Matthay M, McLaughlin G, Natale J, Oren P, Polavarapu N, Schneider J, Schwarz A, Shanley T, Simone S, Singer L, Sorce L, Truemper E, Vander Heyden M, Watson R, Wells C. Association of Race and Ethnicity with Sedation Management in Pediatric Intensive Care. Annals Of The American Thoracic Society 2021, 18: 93-102. PMID: 32776853, PMCID: PMC7780975, DOI: 10.1513/annalsats.201912-872oc.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBlack PeopleChildChild, PreschoolCritical CareEthnicityFemaleHealthcare DisparitiesHispanic or LatinoHumansInfantInfant, NewbornIntensive Care Units, PediatricMaleMulticenter Studies as TopicPainPain ManagementRandomized Controlled Trials as TopicRespiration, ArtificialRespiratory InsufficiencyWhite PeopleConceptsSedation managementPain managementClinical trialsU.S. pediatric intensive care unitsPediatric intensive care unitCluster-randomized clinical trialRacial disparitiesIatrogenic withdrawal syndromeAcute respiratory failureEpisodes of painPlanned secondary analysisIntensive care unitPediatric intensive careAssociation of raceEthnicity groupsNon-Hispanic blacksPercentage of daysRespiratory failureUsual careCumulative dosingPediatric patientsWithdrawal syndromeBlack patientsCare unitIntervention arm