2023
Human-specific features and developmental dynamics of the brain N-glycome
Klarić T, Gudelj I, Santpere G, Novokmet M, Vučković F, Ma S, Doll H, Risgaard R, Bathla S, Karger A, Nairn A, Luria V, Bečeheli I, Sherwood C, Ely J, Hof P, Sousa A, Josić D, Lauc G, Sestan N. Human-specific features and developmental dynamics of the brain N-glycome. Science Advances 2023, 9: eadg2615. PMID: 38055821, PMCID: PMC10699788, DOI: 10.1126/sciadv.adg2615.Peer-Reviewed Original ResearchMolecular and cellular mechanisms of human cortical connectivity
Luria V, Ma S, Shibata M, Pattabiraman K, Sestan N. Molecular and cellular mechanisms of human cortical connectivity. Current Opinion In Neurobiology 2023, 80: 102699. PMID: 36921362, DOI: 10.1016/j.conb.2023.102699.Peer-Reviewed Original Research
2021
Phylogenomic analyses of the genus Drosophila reveals genomic signals of climate adaptation
Li F, Rane R, Luria V, Xiong Z, Chen J, Li Z, Catullo R, Griffin P, Schiffer M, Pearce S, Lee S, McElroy K, Stocker A, Shirriffs J, Cockerell F, Coppin C, Sgrò C, Karger A, Cain J, Weber J, Santpere G, Kirschner M, Hoffmann A, Oakeshott J, Zhang G. Phylogenomic analyses of the genus Drosophila reveals genomic signals of climate adaptation. Molecular Ecology Resources 2021, 22: 1559-1581. PMID: 34839580, PMCID: PMC9299920, DOI: 10.1111/1755-0998.13561.Peer-Reviewed Original ResearchConceptsClimate generalistsDrosophila speciesGenus DrosophilaPhylogenomic analysisSignificant phylogenetic incongruenceEvolutionary genomic studiesMelanogaster species groupGenome-wide signalsDifferent climatic nichesHigh-quality assemblySmall population sizeIncomplete lineageSubgenus DrosophilaAsymmetric introgressionSubgenus SophophoraPhylogenetic incongruenceNew transcriptomesGene gainClimatic nicheGenome diversityNatural populationsWidespread speciesGenomic signalsSpecies groupsClimate niche
2020
The Geometry of Limb Motor Innervation is Controlled by the Dorsal–Ventral Compartment Boundary in the Chick Limbless Mutant
Luria V, Laufer E. The Geometry of Limb Motor Innervation is Controlled by the Dorsal–Ventral Compartment Boundary in the Chick Limbless Mutant. Neuroscience 2020, 450: 29-47. PMID: 33038447, PMCID: PMC9922539, DOI: 10.1016/j.neuroscience.2020.09.054.Peer-Reviewed Original ResearchThe whale shark genome reveals how genomic and physiological properties scale with body size
Weber J, Park S, Luria V, Jeon S, Kim H, Jeon Y, Bhak Y, Jun J, Kim S, Hong W, Lee S, Cho Y, Karger A, Cain J, Manica A, Kim S, Kim J, Edwards J, Bhak J, Church G. The whale shark genome reveals how genomic and physiological properties scale with body size. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 20662-20671. PMID: 32753383, PMCID: PMC7456109, DOI: 10.1073/pnas.1922576117.Peer-Reviewed Original ResearchConceptsWhale shark genomeShark genomeBody sizeGene lengthWhale sharksLarge-scale comparative genomic analysisLong neural genesMetazoan genome architectureSlow evolutionary rateComparative genomics approachLonger gene lengthComparative genomic analysisMultiple genetic featuresCodon adaptation indexMetabolic rateAverage geneGenome architectureNeurodegeneration genesEvolutionary ratesMost genomesGenomic approachesGenomic traitsNeural genesGenome featuresBiological traitstrans-Resveratrol ameliorates anxiety-like behaviors and neuropathic pain in mouse model of post-traumatic stress disorder
Yuan Y, Zhen L, Li Z, Xu W, Leng H, Xu W, Zheng V, Luria V, Pan J, Tao Y, Zhang H, Cao S, Xu Y. trans-Resveratrol ameliorates anxiety-like behaviors and neuropathic pain in mouse model of post-traumatic stress disorder. Journal Of Psychopharmacology 2020, 34: 726-736. PMID: 32308103, DOI: 10.1177/0269881120914221.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factor (BDNF) expressionPhosphorylated cAMP response elementAnxiety-like behaviorNeurotrophic factor expressionNeuropathic painCAMP response elementBrain-derived neurotrophic factor levelsGlucocorticoid receptorFactor expressionProlonged stressStress-induced anxiety-like behaviorStress disorderCold allodynia testsNeurotrophic factor levelsAdrenal axis functionPain-related regionsLocomotor activity testSerum corticosterone levelsMarble burying testNumber of marblesProtein kinase APost-traumatic stress disorderEnzyme-linked immunosorbentClassical animal modelsResponse element
2019
The genome of the giant Nomura’s jellyfish sheds light on the early evolution of active predation
Kim H, Weber J, Lee N, Park S, Cho Y, Bhak Y, Lee N, Jeon Y, Jeon S, Luria V, Karger A, Kirschner M, Jo Y, Woo S, Shin K, Chung O, Ryu J, Yim H, Lee J, Edwards J, Manica A, Bhak J, Yum S. The genome of the giant Nomura’s jellyfish sheds light on the early evolution of active predation. BMC Biology 2019, 17: 28. PMID: 30925871, PMCID: PMC6441219, DOI: 10.1186/s12915-019-0643-7.Peer-Reviewed Original ResearchConceptsActive predationGene family expansionPosterior Hox genesFamily expansionAncient lineageBiochemical innovationHox genesBody planPhysiological traitsCodon biasType II familyGenetic basisGenomeClass ScyphozoaTranscriptomeDevelopmental stagesFirst animalEarly evolutionNeurotransmitter genesJellyfishCnidariansPredationRetinoic acidGenesKey innovation
2018
Inhibition of phosphodiesterase 2 reverses gp91phox oxidase-mediated depression- and anxiety-like behavior
Huang X, Xiaokaiti Y, Yang J, Pan J, Li Z, Luria V, Li Y, Song G, Zhu X, Zhang H, O'Donnell J, Xu Y. Inhibition of phosphodiesterase 2 reverses gp91phox oxidase-mediated depression- and anxiety-like behavior. Neuropharmacology 2018, 143: 176-185. PMID: 30268520, DOI: 10.1016/j.neuropharm.2018.09.039.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntioxidantsAnxiety DisordersCell LineCorticosteroneCyclic Nucleotide Phosphodiesterases, Type 2Depressive DisorderDose-Response Relationship, DrugHippocampusImidazolesMaleMice, Inbred ICRNADPH Oxidase 2NADPH OxidasesNeuronsOxidative StressPhosphodiesterase InhibitorsPsychotropic DrugsReactive Oxygen SpeciesTriazinesConceptsAnxiolytic-like effectsBAY 60Oxidative stressNADPH oxidase inhibitor apocyninPDE2 inhibitor Bay 60Prevalence of depressionOxidase inhibitor apocyninPhosphodiesterase 2Stress-related depressionAnxiety-like behaviorSource of ROSBDNF levelsNeuroprotective mechanismsStressed miceInhibitor apocyninCAMP/cGMPNADPH subunitsBehavioral abnormalitiesGp91phox expressionAntioxidant strategiesPDE2 inhibitionAntioxidant defenseDepressionGp91phoxVivo tests
2010
APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex
Shimomura Y, Agalliu D, Vonica A, Luria V, Wajid M, Baumer A, Belli S, Petukhova L, Schinzel A, Brivanlou A, Barres B, Christiano A. APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex. Nature 2010, 464: 1043-1047. PMID: 20393562, PMCID: PMC3046868, DOI: 10.1038/nature08875.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBeta CateninCell DifferentiationCell LineCell ProliferationChick EmbryoChromosome MappingChromosomes, Human, Pair 18Genes, DominantGenes, ReporterHairHair FollicleHumansHypotrichosisIntracellular Signaling Peptides and ProteinsMembrane GlycoproteinsMembrane ProteinsMiceMutant ProteinsNeuronsPoint MutationScalpSignal TransductionSkinSpinal CordStem CellsWnt ProteinsXenopus laevisXenopus ProteinsConceptsHereditary hypotrichosis simplexSignal transduction pathwaysHypotrichosis simplexMesenchymal cell compartmentGenetic linkage analysisNovel Wnt inhibitorsMembrane-bound glycoproteinTransduction pathwaysHuman hair folliclesLinkage analysisAPCDD1Functional studiesHair folliclesWnt inhibitorsCell compartmentDowny hairsGenesImportant componentThick hairPathwayHairGlycoproteinCompartmentsDegenerative processFamily
2008
Specification of Motor Axon Trajectory by Ephrin-B:EphB Signaling: Symmetrical Control of Axonal Patterning in the Developing Limb
Luria V, Krawchuk D, Jessell T, Laufer E, Kania A. Specification of Motor Axon Trajectory by Ephrin-B:EphB Signaling: Symmetrical Control of Axonal Patterning in the Developing Limb. Neuron 2008, 60: 1039-1053. PMID: 19109910, DOI: 10.1016/j.neuron.2008.11.011.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsBody PatterningChick EmbryoElectroporationEmbryo, MammalianEphrinsExtremitiesGene Expression Regulation, DevelopmentalGreen Fluorescent ProteinsHomeodomain ProteinsHorseradish PeroxidaseLIM-Homeodomain ProteinsMiceMice, KnockoutModels, BiologicalMotor NeuronsMutationNeurofilament ProteinsReceptors, Eph FamilyRNA, MessengerSignal TransductionSpinal CordTranscription Factors
2007
Lateral motor column axons execute a ternary trajectory choice between limb and body tissues
Luria V, Laufer E. Lateral motor column axons execute a ternary trajectory choice between limb and body tissues. Neural Development 2007, 2: 13. PMID: 17605791, PMCID: PMC1949814, DOI: 10.1186/1749-8104-2-13.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsBody PatterningBone Morphogenetic Protein Receptors, Type ICell DifferentiationEphrinsExtremitiesGene Expression Regulation, DevelopmentalGrowth ConesHomeodomain ProteinsKruppel-Like Transcription FactorsLIM-Homeodomain ProteinsMesodermMiceMice, KnockoutMotor NeuronsMuscle, SkeletalNeuronal PlasticityPromyelocytic Leukemia Zinc Finger ProteinReceptors, Eph FamilySpinal CordTranscription FactorsConceptsLateral motor columnLMC axonsHindlimb levelsSpinal cord lateral motor columnMotor columnAxons of neuronsIntermediate choice pointsVentral flankBody tissuesMotor nervesLMC neuronsAxonal trajectoriesLimb trajectoriesAxonsTopographic map formationTarget tissuesLimbTissueTranscription factor codeVentral limbNeuronsMap formationMesenchymeInnervationNerve
2001
Expression patterns of Slit and Robo family members during vertebrate limb development
Vargesson N, Luria V, Messina I, Erskine L, Laufer E. Expression patterns of Slit and Robo family members during vertebrate limb development. Cells And Development 2001, 106: 175-180. PMID: 11472852, DOI: 10.1016/s0925-4773(01)00430-0.Peer-Reviewed Original Research
1998
Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally
Varfolomeev E, Schuchmann M, Luria V, Chiannilkulchai N, Beckmann J, Mett I, Rebrikov D, Brodianski V, Kemper O, Kollet O, Lapidot T, Soffer D, Sobe T, Avraham K, Goncharov T, Holtmann H, Lonai P, Wallach D. Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally. Immunity 1998, 9: 267-276. PMID: 9729047, DOI: 10.1016/s1074-7613(00)80609-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCaspase 8Caspase 9CaspasesCell DeathCells, CulturedCysteine EndopeptidasesDNA, ComplementaryFas ReceptorFetal DeathFibroblastsGene TargetingGenes, LethalGestational AgeMiceMice, Inbred C57BLMice, KnockoutPhenotypeReceptors, Tumor Necrosis FactorReceptors, Tumor Necrosis Factor, Member 25Transcription, GeneticConceptsFas/APO1Death inductionJun N-terminal kinaseHeart muscle developmentCaspase-8 geneCell death inductionWild-type fibroblastsN-terminal kinaseTNF receptorNull embryosMuscle developmentAlpha phosphorylationHematopoietic colony-forming cellsCaspase-8Cell deathColony-forming cellsIkappaB-alpha phosphorylationTargeted disruptionNonredundant roleEmbryonal developmentEmbryosAPO1Fibroblast strainsNGF familyReceptorsMaternally expressed PGK-Cre transgene as a tool for early and uniform activation of the Cre site-specific recombinase
Lallemand Y, Luria V, Haffner-Krausz R, Lonai P. Maternally expressed PGK-Cre transgene as a tool for early and uniform activation of the Cre site-specific recombinase. Transgenic Research 1998, 7: 105-112. PMID: 9608738, DOI: 10.1023/a:1008868325009.Peer-Reviewed Original Research