Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally
Varfolomeev E, Schuchmann M, Luria V, Chiannilkulchai N, Beckmann J, Mett I, Rebrikov D, Brodianski V, Kemper O, Kollet O, Lapidot T, Soffer D, Sobe T, Avraham K, Goncharov T, Holtmann H, Lonai P, Wallach D. Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally. Immunity 1998, 9: 267-276. PMID: 9729047, DOI: 10.1016/s1074-7613(00)80609-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCaspase 8Caspase 9CaspasesCell DeathCells, CulturedCysteine EndopeptidasesDNA, ComplementaryFas ReceptorFetal DeathFibroblastsGene TargetingGenes, LethalGestational AgeMiceMice, Inbred C57BLMice, KnockoutPhenotypeReceptors, Tumor Necrosis FactorReceptors, Tumor Necrosis Factor, Member 25Transcription, GeneticConceptsFas/APO1Death inductionJun N-terminal kinaseHeart muscle developmentCaspase-8 geneCell death inductionWild-type fibroblastsN-terminal kinaseTNF receptorNull embryosMuscle developmentAlpha phosphorylationHematopoietic colony-forming cellsCaspase-8Cell deathColony-forming cellsIkappaB-alpha phosphorylationTargeted disruptionNonredundant roleEmbryonal developmentEmbryosAPO1Fibroblast strainsNGF familyReceptors